CROSS-CONTAMINATION

Dr. Muslim Suardi, MSi., Apt.

Faculty of Pharmacy University of Andalas

Arises from:
Uncontrolled release of
dust, gases, vapors, sprays or
organisms from materials &
products in process
Residues in equipment
Operators

Most Hazardous:
Potent low-dose materials
Sensitizing agents
Cytotoxic materials
Some living organism

Minimizing of CrossContamination
* Facilities
* Procedures
* Air-flow rates & directions

Controll Cross-Cont
1

* Processing & filling in segregate area

* Avoiding manufacture of different
products at the same time
* Containment of material-transfer by
means of air-locks, air extraction,
clothing change, & careful
washing & decontamination of
equipment

Controll Cross-Cont
Re-circulation

of untreated air, or by
inadvertent re-entry of extracted air

Use

closed systems

Common source of cross-contamination:

Ineffective cleaning of equipment

Attention !!
Cleaning of:

Pipelines
Valves
Joints
Bearings
Blanked-off ends
Drying
Milling
Sieving
Blending Equipment

Protective clothing worn

* Should not be worn out side
it Should be laundered in
such a place & manner that
contamination is contained

One product only at a time

* Ovens
* Other equipment

PROCEDURES
Should especially be established for
monitoring likely contamination by:
* Potent low-dose
* Sensitizing agents