Alergi

pada
saluran nafas

Conjunctivitis
Rhinitis

Urticaria

Asthma

Gastroenteritis

Clinical
manifestations
of
type I
hypersensitivity

sensitization

B
Th2

IL-4
IgE
mestcel

immediate reaction

late reaction

eosinofiel

Figure 1. (click image to zoom) Biosynthesis of arachidonic acid and the

cyclooxygenase (COX) pathway. HPETE = hydroperoxyeicosatetraenoic acid;
NSAIDs = nonsteroidal anti-inflammatory drugs.

Step-wise diagnosis of allergy

Probable
allergy

Selective
measurement
of specific IgE
in blood

Symptomatic
therapy
Allergen
avoidance
Immunotherapy

Anamnesis
Allergy ?

Physical
examination
Possible
allergy

positive

Allergen panel
in skin testing
Search for
other causes

or
Plebani, 2003

Multi-allergen
screening test

negative