Joshua Adrian B.

Crisostomo
2FPH
A Reflection On: Modified Release Formulations To Achieve The
Quality Target Product Profile (QTPP)
Modified release drugs can be somewhat called a breakthrough in
pharmacy because it opens up a new way in how we make drugs and
administer them. It brings us more options on administering drug therapies
that are made to improve the traditional ones. In this journal, modified
release formulations are discussed in order for the reader to know more
about the subject, and at the end establish a point wherein the idea is that
these drugs are supposed to make better drug products as a whole.
The journal itself discusses more about modified release formulations
as a whole, rather than taking on them individually. This is to create a better
picture so that it could be further be understood. In the beginning, its
advantages, such as only requiring patient to take fewer doses therefore
ensuring that the therapy is followed, is tackled. Another is that it is perfect
for those who have chronic diseases because it makes the therapy for their
condition much easier. Disadvantages, however, include risk of dose
dumping or immediate release of all doses and toxicity of some drugs. As the
journal goes on, it discusses furthermore the systems of modified releases,
being monolithic or multiparticulate system. The former being a dosage form
having a tablet core that disintegrates through time or passage through a
certain area such as the stomach, and the latter being the one with different
units that are also known as pellets. However, not all drugs can be put into a
modified release dosage form, such as anticoagulants, cardiac glycosides,
those not absorbed well in GIT, or simply those that do not have any
advantages or use for modified release. Furthermore, techniques, methods,
or the types of modified release forms are discussed, for instance, repeat
action tablets, osmotic tablets, or the ion-exchange resin method.
All in all, to conclude this brief reflection, I personally believe that there
is much more to be discovered with modified release tablets for in my
opinion there is more advantage to it than the disadvantages. It could be
that in the years to come more drugs can be implemented into this system

so that its potentials and known uses could be further be used and applied. If
perfected or mastered, it could lead to better dosing, administration, and
overall a better therapeutic experience for the patient without sacrificing the
effectivity and quality of therapy.