*

*
1061 10600

8(1): 2551

(Free Radicals)


(www.th.wikipedia.org/
wiki/)









( www.geocities.com/
hotsprings/bath/8143 /free_radical.html)



28

 Reactive Oxygen Species (ROS)

(www.gpo.or.th/rdi/html/antioxidants.html)

(Nonradicals)
ROS (Superoxide Anion
Radical) (Hydroxyl Radical)
(Peroxide Radical)
(Peroxyl Radical)
(Hydrogen Peroxide) (Ozone)
(Singlet Oxygen)
(Hydrogen Radical)
(Methyl Radical)

2.


(Autoimmune Diseases)









(Doxorubicin) (Penicillamine)
(Paracetamol)

2
1.


(Metabolism)



( www.vibhavadi.com/web/health_
detail.php?id=101)
LDL (Low Density
Lipoproteins)


8(1): 2551

LDL


(Atherosclerosis)
(Mutation)



(www.geocities.com/hotsprings
/bath/8143/free_radical.html )
29



(www.school.net.th/library/
snet4/cell/aging.htm)






2
1










(Antioxidants)

(Oxidative Stress)


(S-H)







2
(www.thaiclenic.
com/antioxidant.html)
1.
2
(Superoxide Dismutase:
SOD) (Catalase: CAT)
(Glutathione Peroxidase: GPX)
(Glutathione Reductase: GR)
(Glutathione STransferase: GST)
(Glutathione)
(Lipoic acid)
(Ceruloplasmin) (Albumin)
(Transferrin) (Haptoglobin)
(Hemopexin) (Uric Acid)
(Bilirubin) (Cysteine)

(Substrate)


8(1): 2551

30

2.
(Tocopherols)
(Carotenoids)
(Ascorbic Acid) (Stearoids)
(Ubiquinone) (Thiols)
(Imosine) (Taurine) (Pyruvate)
(Gallic Acid) (Flavonoids)
(Trolox) (BHT) (BHA)

(Blot
et al., 1993)

( )



(Anonymous, 1994)

( )

(Omenn et al,1994)

(Beta-carotene)
(www.vibhavadi.com/web/health_detail.php?id=10
1)

8(1): 2551

31


(Lee et al., 1999)

45



(Hennekens et al., 1999)



4,802 4 (Anonymous, 1999)

Anonymous. (1994). The Alpha-Tocopherol, Beta
Carotene Cancer Prevention Study Group. The
effects of vitamin E and beta carotene on the
incidence of lung cancer and other cancers in
male smokers. N Engl J Med 330:1029-1035.
Anonymous. (1999). Dietary antioxidants and risk
of myocardial infarction in the elderly: the
Rotterdam Study. Am J Clin Nutr 69(2): 261266.
Blot, W.J., Li, J.Y., Taylor, P.R., et al. (1993).
Nutrition intervention trials in Linxian, China:
supplementation with specific vitamin/mineral
combinations, cancer incidence, and diseasespecific mortality in the general population. J
Natl Cancer Inst 85: 1483-1491.
Hennekens, C.H., Buring, J.E., Manson, J.E.,
Stampfer, M., Rosner, B., Cook, N.R., et al.
(1996). Lack of effect of long-term
supplementation with beta carotene on the
incidence of malignant neoplasms and
cardiovascular disease. N Engl J Med 334:
1145-1149.
Lee, I.M., Cook, N.R., Manson, J.E. (1999). Betacarotene supplementation and incidence of
cancer and cardiovascular disease: Women's

8(1): 2551

32

Health Study. J Natl Cancer Inst 91: 21022106.

Omenn, G.S., Goodman, G., Thomquist, M., et al.
(1994). The beta-carotene and retinol efficacy
trial (CARET) for chemoprevention of lung
cancer in high risk populations: smokers and
asbestos-exposed workers. Cancer Res 54(7
Suppl): 2038s-2043s.
www.geocities.com/hotsprings/bath/8143/free_radical.html
www.gpo.or.th/rdi/html/antioxidants.html
www.school.net.th/library/snet4/cell/aging.htm
www.thaiclenic.com/antioxidant.html
www.th.wikipedia.org/wiki/
www.vibhavadi.com/web/health_detail.php?id=101

http://www.google.co.th/url?sa=t&rct=j&q=reactive%20oxygen%20species%20ros%20%E0%B8%84%E0%
B8%B7%E0%B8%AD%E0%B8%AD%E0%B8%B0%E0%B9%84%E0%B8%A3&source=web&cd=5&cad
=rja&sqi=2&ved=0CFwQFjAE&url=http%3A%2F%2Fsci.bsru.ac.th%2FNew%2520Folder%2F81%2F4%25E0%25B8%25A7%25E0%25B8%25B4%25E0%25B8%258A%25E0%25B8%25B2%25E0%25B
8%2581%25E0%25B8%25B2%25E0%25B8%25A3%2520%25E0%25B8%25AD%25E0%25B8%2599%25
E0%25B8%25B8%25E0%25B8%25A1%25E0%25B8%25B9%25E0%25B8%25A5%25E0%25B8%25AD%
25E0%25B8%25B4%25E0%25B8%25AA%25E0%25B8%25A3%25E0%25B8%25B0%2520(%25E0%25B
8%25AD%25E0%25B8%2599%25E0%25B8%25B1%25E0%25B8%2599%25E0%25B8%2595%25E0%25
B9%258C).doc&ei=RfAuUIneOIOsrAfqzYC4CQ&usg=AFQjCNEYd4FRbfmyBbr7PcOzQWpMPJHi9Q

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