How to determine the sample

patient recruited at major cancer hospitals each region, as well as

of small public and private hospitals were also recruited breast cancer patients, by specially
trained investigators. All breast cancer diagnosis was confirmed by histologist
To include controls, quotas based on age established as a prelude to generate the control group
similar to the case in terms of age groups to achieve frequency- matching . Quota by socioeconomic. Status (SES) also set a priori to control potentialselection bias arising from
participation rate differential. The SES category. This quota is calculated by SES from census
data available in each area of study, to obtain SES distribution among controls identical to the
distribution of SES Among the general population of women, conditional to age