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  • Female Pharmacotherapyk Cardiovascular Diseases

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    chondro
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    Women have lower BMI and smaller organ size, leading to a smaller volume of distribution for drugs. They also have a higher proportion of body fat which may increase the volume of distribution for lipophilic drugs. Throughout the menstrual cycle, the percentage of tissue water fluctuates as estradiol concentrations rise and fall, causing sodium and water retention. For men, testosterone increases muscle mass and augmented metabolism, leading to a higher glomerular filtration rate and clearance. In terms of the cardiovascular system, women have a smaller heart size and higher resting heart rate compared to men. The length of the cardiac cycle also varies throughout the menstrual cycle for women.

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    Women have lower BMI and smaller organ size, leading to a smaller volume of distribution for drugs. They also have a higher proportion of body fat which may increase the volume of distribution for lipophilic drugs. Throughout the menstrual cycle, the percentage of tissue water fluctuates as estradiol concentrations rise and fall, causing sodium and water retention. For men, testosterone increases muscle mass and augmented metabolism, leading to a higher glomerular filtration rate and clearance. In terms of the cardiovascular system, women have a smaller heart size and higher resting heart rate compared to men. The length of the cardiac cycle also varies throughout the menstrual cycle for women.

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    11 views2 pages

    Female Pharmacotherapyk Cardiovascular Diseases

    Uploaded by

    chondro
    Women have lower BMI and smaller organ size, leading to a smaller volume of distribution for drugs. They also have a higher proportion of body fat which may increase the volume of distribution for lipophilic drugs. Throughout the menstrual cycle, the percentage of tissue water fluctuates as estradiol concentrations rise and fall, causing sodium and water retention. For men, testosterone increases muscle mass and augmented metabolism, leading to a higher glomerular filtration rate and clearance. In terms of the cardiovascular system, women have a smaller heart size and higher resting heart rate compared to men. The length of the cardiac cycle also varies throughout the menstrual cycle for women.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 2

    Gender-specific physiological differences

    Women

    Men

    Lower BMI and smaller organ


    size smaller Vd
    Higher proportion of body fat
    -- may increase Vd for
    lipophilic drugs
    % Tissue-water fluctuates
    throughout menstrual cycle,
    as high estradiol
    concentrations are associated
    with sodium and water
    retention
    Testosterone-induced
    increase in muscle
    Lower
    and CLcr.
    NicolineGFR
    Jochmann,
    Karl Stangl, Edeltraut Garbe, Gert Baumann and Verena
    --augmented
    Stangl - European Heart Journal metabolism
    2005 26(16):1585-1595

    Cardiovascular system of women and men


    Women

    Men

    Heart size is less


    Resting heart rate in women is 35 beats higher
    Length of cardiac cycle varies
    Length of
    throughout menstrual cycle and cardiac cycle is
    is prolonged during
    longer
    menstruation.
    Longer QT interval and a shorter
    sinus node recovery time.
    Women have a 5070% greater
    risk of suffering ADR

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