Check at OS LEVEL .

The following test can help further clarify the problem:

1. Log on to the SAP Web Application Server at operating system level (Windows, UNIX, and so on).
2. On Windows, start a command prompt (input prompt).
3. Enter the following command:
telnet {mail-host} {mail-port}
whereby you replace {mail-host} and {mail-port} with the values that you entered at the SMTP node in transaction
SCOT (without the parentheses). If you then receive a response starting with "220", the configuration is correct. If the
system issues an error message, you must request the correct values from your mail administrator.

SYNTAX: telnet {mail-host} {mail-port}

EX: telnet smtp.secureserver.net 25

Please Refer below snotes:

SNOTE: 455140 E-Mail configuration
SNOTE: 607108 Problem analysis when sending or receiving e-mails