Carcinogenicity/Mutagenicity/Teratogenicity

No mutagenic, carcinogenic, or teratogenic effects have been noted in studies performed using
commercially available ginkgo products containing 2227% flavone glycosides and 57%
terpene lactones (Blumenthal, 1998).
Endocrine Effects
A study (Amri et al., 1996) of GB extract 761 in rats demonstrated that high doses (10100
mg/kg) of the extract, as well as isolated ginkgolides A and B at doses of 2 mg/kg, decreased
corticosteroid synthesis by up to 50% and 60%, respectively. An associated increase in
adrenocorticotropic hormone (ACTH) levels was also seen.