FISA DISCIPLINE! Nuntiirul total de ore (pe semestru) din planul de invigimint a 36 Denumirea discipline’ MEDICAL ONCOLOGY-RADIOTHERAPY Anul de studi IV | Semesteul * 1 | Tipul de evaluare finala(E/V/C) | E Regimul disciplinei (Ob — obligatorie, Op — optional’, F - facultativa) Ob | Numarul de eredite | 2 ; ; Total ore de studiu Total ore pe Total ore din planul de invayimant | 36 | Oar ere* so | ioe 86 Titularul discipline: Conf. Dr. LUCIAN MIRON * Daca disciplina are mai multe semestre de studiu, se completeazii cAte o fis pentru ficcare semestru = - | Torat c#] os | Lu |p Facultatea Medicine | 36 2 | a4 ‘Departmental | Medical Sciences tf Prone Cg * C— curs, L — activitati de laborator, P — proiect - sau luerdri practice Medicine Cunostinfe minime necesare studen(ilor pentru parcurgerea nofiunilor de eurs/stagii/Iuerari | practice _ ~ elements of epidemiology: relevance of cancer as a public health issue, risk factors ~ topographical anatomy, semiology: diagnosis and staging of malignant tumors ~ elements of physiopathology, immunology and genetics: cancer genes, malignant phenotype, fundamental biological alterations in cancer ~ internal medicine and surgery: clinical and paraclinical evaluation of cancer patients, follow-up and the diagnosis of relapse, principles of surgical resections in oncology, symptomatic treatment and best supportive care in cancer Obiectivele discipline! ‘Training medical students on general principles of genetics, molecular biology, pathophysiology, diagnosis, treatment and monitoring of cancer in the multidisciplinary approach of malignancies, in order to raise awareness on the frequency, magnitude and significance of oncologic pathology, the importance of early diagnosis and proper management of malignant tumors, and also the impact of intricate social, economic and psychological issues.Programa analiticl a cursului ‘Cancer: Definition. Malignant phenotype OO * cancer definitions, history, place in contemporary pathology * malignant phenotype, malignant cell biology * aspeets of descriptive epidemiology of cancer: incidence, prevalence, mortality + risk factors sis. + types of human carcinogenesis (physical, chemical, viral) + factors involved in human carcinogenesis + cancer genes - _ Local invasion and metastasis. Prevention of cancer. * the “metastatic cascade”, pathways of metastasis, clinical and therapeutic significance * tumor angiogenesis — biological and practical importance * primary, secondary and tertiary prevention + early detection and cancer screening - principles, practical results gnosis and staging of cancers + principles of clinical imaging and diagnosis of cancer + cancer staging: TNM system (objectives, principles, role, practical importance) + paraneoplastic syndromes; tumor markers: biological and therapeutic significance Principles of loco-regional cancer treatment + principles and indications of surgical treatment in cancer + radiotherapy in cancer (physical basis, radiobiology, treatment planning, side effects). Principles of systemic cancer treaiment + anticancer chemotherapy + hormone therapy, biological therapy, gene therapy in cancer + global therapeutic strategy in cancer: multimodal treatment Programa analitied lucriri practice/stagi Cancer: definition, place in contemporary pathology. Descriptive epidemiology * presentation of the oncology service, frequeney and importance of cancer in current pathology + epidemiology of cancer: dence, prevalence, mortality + records and circuit of cancer patients, cancer registries. ‘Cancer etiology, risk factors. Carcinogenesis - the process steps. + cancer risk factors | « carcinogenesis as a biological stepwise process; physical, chemical, biological | carcinogenesis, | «case presentations: lung cancer —_ Invasion and metastasis - clinical significance, types of metastasis + clinical and therapeutic significance of invasion and metastasis + clinical types of metastasis | | + case presentations: breast cancer, gynecological cancersEarly detection and screening in cancer: principles, techniques, practice 2 + “warning signs" of cancer + tumor markers: role in screening + principles and techniques of cancer screening + case presentations: ENT cancers, sarcomas, malignant melanoma Clinical diagnosis and staging of cancers 2 + oncology patient chart, physical examination technique + assessment of physical performance status (Kamofsky scale and Zubrod/ WHO/ECOG scale + cancer staging: principles and rules of the TNM 2009 system + case presentations: digestive cancers (colon, esophageal, stomach, rectum, | pancreas. liver) Principles of active oncology treatment 2 + oncologic surgery: indications, recommendations, limitations + radiotherapy: presentation of radiotherapy equipment, radiation protection standards, side effects + chemotherapy, hormone and biological therapies in cancer: clas: indications, results, precautions, side effects + case presentation: urogenital cancers - Response evaluation. Oncological emergencies. Principles of supportive treatment 2 + therapy response evaluation criteria + oncological emergencies: diagnosis, treatment + symptomatic and supportive treatment + nursing of the terminal cancer patient ication, ‘Competente practice dobandite Ia finalul anului/semestrului ~ theoretical — knowledge of the general principles of oncology (cancer definition, epidemiology, carcinogenesis, local invasion, ability to metastasize, early diagnosis), of the principles of clinical, imaging and pathology diagnosis of cancer, staging and use of tumor markers, knowledge of predictive and prognostic factors and of the fundamentals of therapeutic decision and global strategy in major human cancers. + practical ~ clinical examination and correct completion of oncology patient-specific chart, aequirement of medical oncology vocabulary, knowledge of the main methods of screening, primary prevention measures, elementary organization and logistics of a cancer network (guidance of neoplastic patients to specialized sectors), recognition of early symptoms, basic concepts of cancer therapeutics, monitoring and treatment of radio- and/or chemotherapy side effects, long-term monitoring of cancer patient and diagnosis of relapse, and also the subjective knowledge of neoplastic disease, the impact of this disease (and cancer therapies) have on the physical, emotional, spiritual status and interpersonal relationships of the patients.Ponderea in notare exprimata in La stabilirea notei finale se iau in considerare procente Total = 100%) ~ testarea periodica prin Tucrati de control | 0 ~ activitafile gen teme / referate / eseuri / traduceri 7 a roieete etc. ~ alte activitati (PRECIZATD : colocviu 20 jescriefi modalitatea practicd de evaluare final E/V (de exemplu: Iuerare scrisi (descriptiva sivsau test grila si/sau probleme etc.), examinare orala, colocviu individual ori in grup, proiect, ete.) ~ Colocvii semestriale, raspunsuri la lucréirile practice -_ Examen final: examen oral si lucrare scrisi descriptiva Estimai timpul total (ore pe semestra) al acti filor de studiu individual preiinse studentului {completaji cu 0 activitiile care nu sunt cerute) _ B Desoiaea si studio notiielorde 7 5] egstire prezentiri orale . 2. Studiu dupa manual, suport de curs | ° | | 9, Progatire examinare f | 6 10. Consultagii 3. Studiul bibliografiel minimale indicate ; a 4, Documentare suplimentara in , biblioteca 4 | | 11. Documentare pe teren 0 5, Activitate specifica de pregatire _ ' INAR si/sau LABORATOR | 2 | | 12-Documentare pe Internet | 6. Realizare teme, referate, eseuri, ; 6, Realizare teme, referate, escuri 4 | [13. Ate activitat.. | waduceri ete. 7. Pregatire lucrari de control 2 | | 14, Alte activitagi ... 0 “TOTAL ore studiu individual (pe semestru) = minimum 50 Bibliografie obligate J. Miron L, Marinca M. Oncologie generald. Editia Il-a, Editura Gr. T. Popa Tasi, 2012. 2. Miron L, Bild E, Ingrith Miron, Curescu St. Elemente de nursing in cancer. Editura Gr. T. Popa Iasi, 2006.Bibliografie suplimenta 1, Miron L (ed) Terapia oncologicd - optiuni bazate pe dovezi. Editura Institutul European lagi, 2008, 2. DeVita VT, Jr, Lawrence TS, Rosenberg SA, DePinho RA, Weinberg R (eds) DeVita, Hellman and Rosenberg's Cancer: Principles and practice of oncology. 9th edition, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2011. 3. Casciato D. Manual of clinical oncology, 7th edition. Lippincott Williams & Wilkins, Philadelphia, 2011 4. Abeloff MD et al, Clinical oncology, 4th edition. Churchill Livingstone NewYork, 2009. Data completirii: Semnatura coordonatorului de a didactica 12-10-2012 <