Academic Press is an imprint of Elsevier

32 Jamestown Road, London NW1 7BY, UK

225 Wyman Street, Waltham, MA 02451, USA
525 B Street, Suite 1800, San Diego, CA 92101-4495, USA
Second Edition 2014
Copyright 2014 Elsevier Ltd. All rights reserved
No other part of this publication may be reproduced, stored in a retrieval system or transmitted
in any form or by any means electronic, mechanical, photocopying, recording or otherwise
without the prior written permission of the publisher
Permissions may be sought directly from Elseviers Science & Technology Rights
Department in Oxford, UK: phone (144) (0) 1865 843830; fax (144) (0) 1865 853333; email:
permissions@elsevier.com. Alternatively, visit the Science and Technology Books website at
www.elsevierdirect.com/rights for further information
Notice
No responsibility is assumed by the publisher for any injury and/or damage to persons or
property as a matter of products liability, negligence or otherwise, or from any use or operation
of any methods, products, instructions or ideas contained in the material herein.
Because of rapid advances in the medical sciences, in particular, independent verification of
diagnoses and drug dosages should be made
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Cataloging-in-Publication Data
A catalog record for this book is available from the Library of Congress
ISBN: 978-0-08-098347-9
For information on all Academic Press publications
visit our website at elsevierdirect.com
Typeset by MPS Limited, Chennai, India
www.adi-mps.com
Printed and bound in Great Britain
14 15 16 17 18

10 9 8 7 6 5 4 3 2 1