(19) RH) SEE AAP AL [51] Int. Cl. A61K 31/245 (2006.01 ) . (o] RRS AR BARB AR! comer) * + * 21 8S 200610073074. 3 AER 0S C006. O11) * SS AGLP 1/06 2006.01 ) [43] 9FB 2007 4 10 HH 17 H [11] A3FS CN 1010535624 [22] ig 2006.4. 12 [21] #8188 200610073074. 3 (1) BBA JERR SAMRAT RAMA AL Seu 100089 tk 3 TN ie te OE BE 3 BEE (2) eA 3K ARAL LTH OL HE ([s4] mea REAR [57] RAAT AIT hy RE He EE H, STARR AEREM AAA. PRA PIA HEE S PPAR HORA, RSP RE ITE S SMR PE 90% ULL, AAT RAR AR PETE. RU ME HUI Teak.200610073074. 3 RAK +H S/T 1, HESSD, SOME T O77 5~100mg HEIR, ELIE OR SHE 5 APPA 90% Ube 2. WRAEER 1 RNA WA AY, FEE TOT 2A A ET). AEA, BRAM H. 3. WUAIBOR 2 FARM BW Ay. HORE CET TAR A Tk CREM CE SHER, ARR TE RARE — MRS, PLC. 4, WRAEER 2 RNA A, SOEET PAS B FUE. HE. WI, BR. PRATER NARS MH, HILAL AER 5. WAIER 2 TRAM AWAAD, SORES RAE AR, BRR, BEAR 8, BOR, REPRE Ht, IRR. 6. WAIEER 1-5 E-ATRAMAG, JORELET BA 20-80% FL. 5~S0%0 HL HET HE Hy 2~1SWAR EAA 0.5~3 70 NEAR» 7. WAR 1-6 E-RAARNAWASY, MEET RAWLS AREER. 8. WAAR 7 PRAIA WA SD, SORE LET A EKA 3%. PRILAB AF 35°200610073074. 3 it mo SA/TH SOBRE BARR ARG RF RHA, ARVYGR-MAST BARRERA SEN, BTA BREGKHAWA AD. TRAGER ARZE 5 ATURE, FORINS HIE 5 SHARAN 90% LE, MATURE EI. ORME REITER HER SRR FH He iB LB ARI HE EA, TT CN WUE REA. REG A USA978772 Hi TE EE TT LT FAI 6 SR SIE, AATEMARP RS, MARTA CK, FERIA, ABA TAFT. JR AIP IRSE LY, RARER TEACH UE ARE. ZEB A] EPO270503 +P HAR ZEPEY A] CN00808894 Hk TRAM. AER METE INTE, TABI AL FEORMRR, TTR ZTE ARG) 0. ee ASR TRE CT AIA — ARBEL, MEM BUM T RIE, FARE A AA WTAE A TARR Ai REE AA HA, WAAL A Menarini 2) 47" 09 ith 2 A EB RE {ELA FAURE. RSME 45 PHA REIA 80%LLE, HANMER, TREE KR PAMRME. BT R-MET OR, REAM WAAMLTA OEM. PE RAMAN SERA MRE, BAR, KPHMMENRAREAWASH. 1K AOWAT AT bABRAERABE, GATAMRM A. ARAN AMEE200610073074. 3 BoB Re/TH REE 5 oy PAS HAL, SOCK OP LH ZE 5 SEPA 9O%LLE, HARPER RY. A ITIVE 24 ATS HEAL. KRG Wile TERE EME, AFAR, IPT RACH DTS. A BRAS BINTE EER, FLEA RAF ANTE, AR AY AY RTM FRA REE ARAWSWAAW AEA 5~100mg HIRE, FURINEHIZE 5 HEA 90%LL LE. KRAOBVAGD, LT MT, SC. BAIS. ARANBWASW, TK ARRAN. (AUPE, SUBIR TE A, RIE E HS ATE ARAL, PE. BRA SAWAS MD, AK AU. OE RU. BPD. GER eT eRe ARS TEASE, Thi FLA. ARUOSMASM, TR ARI. GENER, BRA. BSR. <4 AEDS AEA, COLETTE AK. ZB. KRG BHAT, HBA 20-80%TE 5~SOWARTHER. 2~15%028 BORER, 0.5~370RR NEAR. ASIA 95%Z.8F 30m fF WHT. ARVBWASWT, BALES A 43.33%FLK. 20.67% HER. 8%2CBOREM 1.3% AGRE. ASMA 95% Z.NF 30ml HEA Fo KRAOBWAGD, PLU. BUNT. BRUTE, TERRE. BARA CBR AER EN, SEAN 3%, PILATE 35° BRAN RAE: AREER AR. RS, AE ‘lL, RRA THIS, MIATA, ADEE BRHEARIE. ARMA RARER AD WALL IT RE, FAs BRR, FR, RATHER. RCRA SIS. IA 95% ZRH, #530 ABNEY, 45~65'CFHR, AKAHESHIZE 340LLF. 4200610073074. 3 BoB R87 CFR 30 ARR, MAME, RAS. D FRA Buide eae. ARWWRAET, SAG ES GIRL, TOR RAK. ZS HL, RAM ARAL PRIN a, THER, HARARE, BE, ARM FL, KARAT, ULE, RAL, MARE RN SHE HH » WA FAL THe PR HS SE HAT 6 ZN ea OR SSH Seo 1 40mg 3 EFI PE BEE SLE RRA Hl BK FERRARI ELE 40g, TUBE 65g. TEM 43g. ZEHORHEMM 20g, RAW], MA Lome BT IMO, 24 ABEL, 60°CREAFHRR KS /)F 3%, 30 ASR, INA BENRAEE 2g, RAS “), HEB, BA. STUD RA Es Rabe BR ‘HELMET DE MEI, Pop him L BEER BEG, RAUL, BURCH AER RELI E Hatem kat (%) 5.29 tik fC) 52 ARIE (%) 15 RERIES (%) -7.26 ~ 6.48 YELLE (5S PRIFE, %) L200610073074. 3 BoM BATH BRR, RAFU EACLE, JRA OWE BREE AL, AOA, BOLT SEAN, TO ALORKR, FIN, RRA, BNE, SCENE. BERS FER. FAL, RMI De A eH ESE. Seite 2 40mg SRF ISEB E LIE RRA Ae PEREIRA 40g. UAT HER 65g, TUBALWEHS 43g, SCHORAENY 122, AI. MA 22072 PEE MERIC, 24 AHIR, 60°CRRAFIRR KAN 3%, 30 AMR. tn AGLI 2g, HAHA, HERE, BIG. SHUM Rio F RR BR LRA AE REDD, YORE SBE Le FURS ALE WE, ASULRRL, BURT L HER LIE BiB eeF IK (%) 428 oR AL_ CD 48 BRU (%) 30 RBH (%) -5.36 ~ 5.78 YEH (5 SERINE, %) / GRA, RRA He RS TBE RRL, FER 2S RATER EAH, 78 TG ALEME, BERTONE EE, TO EUR, FIZ, A, atte, SRAM, BERRIES. AU, RHUL I 6200610073074. 3 BoM B87 Sew BA 3 Omg 9S EES BRE AD TK HERERRE Se. FUE 20g. HALT HERE 100g. ZETRMEMG 10g, IRAHIA, MMAR 5%2E POR AER Z RAE REIYOM, 30 Fl HEL, 60°CRERFARD AA NF 3%, BERL, NBER 2g, WES), WEBER, BNE. TM Roo Fs SRE wR BRL HE Ss PSE SiR, AFTERALL ARE RK, AS BR TUTE RAG, Mb, BUR) RELA aE BE WKB (%) 2.79 PRL CD 40 RELI (%) RRER (%) FEL (5 A PRIEE, %) URAC, RA FURA RAM RACLL, JEL SSRI OR HEAR MHI, Babee SB, AP RORA, HARK, TAD, SCRE, REZC ZEMPERITERIA, HEUIAEIA 84%, (AAA. Seite 4 AO mg SEF EE CRE AY AL RAD hl HERE 40g. TURE 33g. TRETHER 80g. APURAEAM 10g, IRAHIA, IAT ‘HIR, 28 Hi islAL, 60 CRAFIRAEKA DF 3%, 30 AHR, I MERERREE 2g, RAHI, ce SMR EF200610073074. 3 wh e/TaR ® RR ER ‘RLM ABE Sih, PRAT FIRS MER RAK, BBD, BURLY) URL tE ERT Ik5} A) 2.89 Tiki CD 38 RCH (%) - 92 RES (%) “3.55 ~3.19 SELUBE (5 OMERRGRE, %) a1 BREA, Sail RFRA RAC, JAERI, LAKH, SBIR, SALTER, BURLUCAE ES, HARE, HEME 91%. 40mg BL AFSL AEE HI 2 RRA lh HH: HER EHWK 40g, FLBE 280g, HURATHER 20g, RHEMM 10g, AH, MALKZ REAM, 28 AKL, 60°CRA FRA KAT 3%, 30 ABER, IA DRIRAREE 2g, 1 eh), HERR, BNE. SRAWA ROE: Rahs GR ‘aL A SD BE SHB, POLARS FREER RAs, ABD, BURT BRL Ea HE Wea BE AG (%) 2.67 thik fa CD 35 FREI (%) 93 RERIE (%) -3.34~3.07 EHH (5 SPRUE, %) _ 2200610073074. 3 BoB R/T RA, FLOR HEAR EL, IFLR, BAEK ZR, AL, RERUN THR, BURTON, BURR, URERRIER/), MEHL REIA 92%. SHB 6 40mg 9 EP PRE RE HS A ARAL TIA HERP IK 40g, PURE 65g. BUAHER 31g, BORER 12g, WAKA, IMA 95%Z, BORIS RIM, 28 FHRL, 60°C RFRA ZK SbF 3%, 30 AMER, IA BEARARBE 2g, Weis, WEBER, BIE. ROWER: 75 Rta SR ‘LEED SEL, PATA REE RAG, A>, Buns RRB J Ha HEBERT KB) Zz 2.65 Hib f CD 32 PRL (%) 94 HERES (%) -2.36 ~2.78 PELE (5 SP PRIREE, %) 93 BRR, RPA RACE, FEAL, BLA 956 ZAK EK Bh, DHL, MUL TPR, BURLTESN TERE, BURR, FURR), HEIN RELA 93%,200610073074. 3 it OH Bt A/D 120 100 PE 20 a @ it One 0 > oo ame me } 4 ; o 7 | ° 20 40 Ci 80 8 GP 7 il 10