slestvs teense you cover them all Wo Dainiton oars) Diss co 0 Fasing 370 <70 soso 2howr ama vant 98 ce 26(A8 lin) 6.064% (82-47 mmelimot-pre db} ‘seaton ‘ype 10M Type2 0M Ketosborone Nonketoss prone equrement fornia Insta estan define eae onset ito onset Nonotese obey asad vote ose (35 yas sty >So years sae th HUADRS &ORE No MAceltion| vein 10% Paseein 308 Someone in Eins 200% con. nM wins ‘Other tpe of diabetes Secondary to pancreas. chron pane, hemochromatosis Maiuttonreatee betes Endocrine dst - Cashin Aeromesay, Pace rv Insced Steroids, thie, artis aye an zsyehots. Genetic syndromes Fecha, ysropia Myotoni esaiona betesTe -26/ 3000009 U6, 801 Find) ‘ye -pralence xin neon in South sane Causes Wet Geneve environmental sults -Cossatie 8) “pez Metabolic Syndrome - Obey, Hypertension, insuin resbtance, Oysipdaemis, Abdominal Adipsty Tesetmaat et Corpertoe of a- tgh lve, law ft low lor for bes, ows ooymassindex- Wah (eight) 20-249 noma 125-289 grade obesy Bh 30-40 grade besty a> 40 grade obesty rues ‘ro ypooheaemic Ages (OHA) Sulphonyuress = enhance ndogenous isu secretion =|: weight gl, hYp08) igvondes reduce appetite intestinal cas uptake decease ucontogenesi incense ucre vate -tneeas prigheral cose sens (noses, sacs) GtP-tannlogues simulates reese, reduce appetite: nausea, pancrestts) tptne OPP iors enhance GU fe paca) cealussidaseinhibitors-redvce gos absorption eosin, danroes) Cttarones PPARY apne (es welt gi, dems, postmenopausal, 2a C3) Must ben conuncton wth it. UredinType 2 whan aa + OMGA's fat opines Oxedaybara: Tablet intermediate ong acting sin ‘een daly fied mate: ef 30/70 mix (20% sublet), 7OK ntemedite}Bastboks: Rap with eas log ntermedate acting athe Measuring esemieconrol- Home luce esting HAL, Fretosimine Tae HbA deoends on ps, duration of DM comers omissions of dabees este oma, -Hihbiced pcos (52) Acido ph «73,8 15 Ketone + n/m Detain Kusama, Ketones ones Re alds ntn () os Wiehe tease -faranedehytation and hyperosmolar (2xNarK Urls 7340), mycunytivomtoss 1 in, inn for 122 ows han ow don, 2 coaglton ypoaysemin gl Re depand on consovs eve gcasaral/paagovim cag bucaly acc ais Matformins cea fre ron aorsclar cro} r0/ 0 Prevemlon: smoking est, (Ot coesterl <0, 8° < 140/80 aac reduction ndiuliedseeening for compan. Micowscuar ewnopatny cone Background icoaneuysns, oot haemorrhages har enue (prghea) Severe ackround RMA sft nudes (cotton woo spt enous beading Proleratve neorasculasaton ube 85aclopathy retinopathy ear tormacula europethy Syeotoms- paraesthesia, numbness, dysethes,hyperestesa Sion acest alerts, Decrease breton / PP muscle wasting Urs Chara nt Autonomic neuropathy Impotence, Gasopres,athoes, Gustaory sweating Atos badder Fonturathyptenion Nephropety Syodiome ct Hypertension Petenua, Dering eral function Pholgaliesion-_naduar lameruoseoss- (mmesten-so etn) Creat >150-sox renal anton gore e-ACEL at stage of mkrotbuminro NoteType ory 2 with proteinuria have 10k of Mi compared to onda upacaovoay moni toss of ACTH, GF 15H PRL Causes: Adenoma radon, fart Sheehan ntraton (Sra TB) Sumptoms: Lot of, weakness, amenorhoes, impotence, depression, hypothyroidism ses ao, HypthraldAbsentpubleolaryha, Testa atrophy, ul elé fc, Postural cs Inelin Ses Test variety “Treatment: Hormone replacement Hydroortioe fis, Te tesastorene HT, ‘ontation inductionMiro: / macroprlectiooma, drugs (ttbemetics, anti psychotics), pregnincy, Iacaton, stress, pothyroidm, Remember stalk compression can caus igh PRL symptoms: Amenorhogs eecondary),nfrtity,Glsrrhoes, impotence Sens: Gataorhoes, VED % Prolactin TF, GH Corso ani paar ‘Treatment: OA agonst- romping, Coben, Prglse sgeey ‘Acomesal Symptoms: Neadaches, arbalga, sweating Increased ring/shoe St, weakness, dlabets carpal tunel Sie: rognatism Spee hands, prom. supaor ide, temporal heninopa, hypertension c COT GH should suppress wth lucse IG, pay Treatment: eveotie-somatestat analogue surgery ‘cushings sundrome oues:——_Putary tumour, Ateral tumour, opi ACT Sal eC) Simptoms: —_Wesknes, depression hsitsm,ameorhoes, waht in Se: Prov wesnes, tn sn tren, abdominal sie (pup esteoperss, moon fac, hypertension, btae hump, hsm w Confirm cutings: Low dose OHM suppression x 2g before bed ‘cots suppresses to 180 2.24 be Urn Fre ont-levated Find au 1. Meh dose Dx suppresion-2mg 6h for 2 ays cat <0 of bal levl-PTUTARY No suppesio ECTOPIC ACTH ADRENAL CA 2. ACTH- Hh cope low adrenal Crean abo Na scan pittysumotoms: Sis Adteneyses-Metyapone Ketocore, tar sugey Bate adrenalectomy [elons synome} Acre fare (otcinane) eel tcton eningococasepisems) ‘Wart os, snore ednes depcessionamenarhoe, Sarboes ‘Wasing buccal pementalon, postural hyotenion tow, ih hypogaea, ypecaria Normechromieye anaemia x arena nT ‘hort smacthen et long syracthn if conidering exogenous ster supers) ydrcotsone 15/5, Fusrocortsone 0. roves disest, Tene multinadlr nodular gre, Tes node Wolo, were, anaety, he Intl elgomenorboea, dares, palpation, swetrg “achyeaaa A, Tro, Palmar ethama, Ey signs (xophtaos, lg Bd retraction, ‘opthaoplegia, orev rts mycedema, ropa {TFT anos, Technet scan orbnaiole (beta backers], aston, Seer Hashitos Tyr, neck radiation, aising ‘Wei ain constipation, menage, ci ntolerance, dementa ar ss Course aces, dy tn, Sow rain retines TH, PO ntboses, Thyroxineuses Symotoms/Signs: Symptoms: Smal cle, Pulmonary sees, preumoni,T8, CNS tour, ning, abs, Poh, Chlrpoprnie, arvensepne,Cyophoaphamide Symotomahias of ae Eee fuld atu, ional hyponatraemia Low plasma osmoaty Isoroprte Nh rie osmobaty Lina Wa excretion eh Normalrenal/aéreal tinction Fi restieton emethycloretraccine (Demeclocyine) ‘cana Caniopharyrgiona/Phutary tumour, TB, mening, seeds, Sheers, lOMOAD Nephrogen: Real tuba aos, Mypotalsemia hypercleeria ‘ues, Demeclcyeine, encase Polya, srmptoms of ae perataemi, High plama oma, napprp.ow win osmoaty “Water deprivation -aluceo! urinary concentration IM GAP ater water degen - increased uray concentration = ran Di 90 inceasein urinary concenzaon-nepvogene Ot Canin: AVP (desmoprestin -nasa spray Neplvogeie: Diteteslower Na}, NSAIDS Dietary, malebsorpion, chronic renal flr, Vt D restart kets oil hypophosphatzemi,phencin ‘wadding gt, bow es bone pla mala tow Pgh ak ghes,Lon/nermal C2" Losers zones on Xacauses: Post menopause, Cushing Dibetes,Thyotocoss Hypeeenadsm, rome, ‘ha mobi, Cron real Steroids, Heparin ‘Smptoms Fractures rays domineralsaon, cus vertebrae. DOA sean—Tseare 25 Re HT, Calum, ophosphentes superar Cauresof ypereaicaemia: ——Hyperpcatiyoiin, Excess vt saeco, ital, thie, exon of hyper ‘Symptoms rmalgnancy, totale, Aon, Far! hypocalea ypecaleemia Primary hyper aati adenoma Secondary hyper -hypervophy of parathyroid to hypocalcemia cereal fre Tertiary hyperPT «autonomous nodule ater long sanding secandary apes Poy, pote rena col, haemtura, bone an pep ucerston Hid cow Pgh ak phos hgh TH am nero renal stones Xraysothands-sbpeastal erosions surgery ‘accor semaine, 20s maleran.sympsthete chain Panic atads,paptatons tremor, sweat, headache, Pushing letematent hypertension, tchyare, postural hypotension eycosuria Pentium supresion et fal suppress‘Syaptoml ns: Muli EndocneNeonlna MeN Wermrs syndrome: ‘MeN ta (Sones syndrome) Vor tppe nau: CTsean or MBG scan ‘pha back henowybenzaing) beta back ropranllh drnal aroma, lateral adrenal hyperplasia rperensior Low Hh nay toss vated Adsterne, Suppressed ein ety crsean Splronoactor, urgry Agen uur ese wth rer met rare Flushing. teria, water darhoes, abd p, wes, ‘wel plnenary ae ens, yao epstamegay arr uine SHAK wei Sine Pray, Pancreat (GasVSucagon/suln, PRotry ‘Madar a Thyri, Paeseromecytms, Patho hperlaa a plu: Mavfaneld ius, Moccia gargloneronss, Autonomic stuneten Phacocomocyons, Reta angomas, Ceebearheenangoblstoms.