Acute Toxicity is measured in

LD50 and LC50

lethal dose

lethal concentration

E
ID
IC
ST
PE

Lethal Dose (LD50)

HIGHER LD50

lower toxicity

higher toxicity
=

LOWER LD50

Categories of Toxicity
Toxicity
Category
I
Highly Toxic

Signal
Word

Danger
Poison

Oral
LD50
(mg/kg)

Approx. Adult
Lethal Dose
( oral)

0-50

Few drops
to a teaspoon

II
Moderately
Toxic

Warning

51-500

teaspoon 1
to
ounce 1

III
Slightly Toxic

Caution

501-5,000

ounce to 1 pint 1

5,000 <

pint 1
or more

IV
Relatively

Caution

Carbon monoxide poisoning

characteristic red color

Arsenic toxicity(.4)

Chronic arsenic
:toxicity
keratosis of palms
and soles, and
hyperpigmentation

:Mee's lines
white lines on fingernails
can be used to determine
chronology of exposure to
arsenic

Mercury toxicity(.5)

Severe stomatitis, swollen gum ,salivation

. and bleeding

Allergic Skin Reactions due to

sulfur appear as :
Contact dermatitis ,Burning
pain and Maculopapular rash

Copper toxicity(.6)

Jaundice of the gum, conjunctiva third

eyelid and sclera of the eye in chronic
. copper toxicity

 .


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. )(

:Digitalis purpurae )fox gloves (( 1)