Agustian Deny

I11109090

The effect of aerobic exercise on serum IL-4 and TNF-alpha of patients with
allergic rhinitis
Fu H , Yu P
Lin Chuang er bi yan hou tou Jing wai ke za zhi = Journal of Clinical Otorhinolaryngology,
Head, and Neck Surgery [2013, 27(23):1321-1323]
Type: Journal Article, Randomized Controlled Trial, English Abstract (lang: chi)
Abstract
OBJECTIVE: To investigate the effect of aerobic exercise on immune factor IL-4, TNF-alpha in
patients with allergic rhinitis, which provide a theoretical basis for the treatment of allergic
rhinitis.
METHOD: Thirty-two allergic rhinitis patients were selected and divided into a control group
(14 people) and the experimental group (18 people). During the treatment, both groups receive
conventional symptomatic treatment. Meanwhile, aerobic exercise therapy is applied to the
experimental group for 40 - 60 minutes a day, 3 - 4 days a week. Serum IL-4, TNF-alpha and
allergic rhinitis symptoms graded scoring were tested before and after 6 month therapy.
RESULT: After six months of exercise intervention, the 11-4, and TNF-alpha levels of
experimental group were significantly lower than the level of control group. The symptoms score
is also significantly decreased in experimental group.
CONCLUSION: Aerobic exercise had good therapeutic effect in patients with allergic rhinitis.
The mechanism may be that aerobic exercise can reduce the level of IL-4 and TNF-alpha, which
can relieve infiltration and activation of inflammatory cells.