The first thing is to make sure you are using good quality data for your calibration.

buy
good pressure gages and have them calibrated. Don't necessarily believe SCADA data
just because it comes from a computer.
Make your comprisons between the model and field data in terms of HGL, not pressure.
Know the elevation of the pressure gage as accurately as possible. Use a high quality
GPS if necessary if you don't have a lot of confidence in yoru elevation data.
Be sure that you are getting a signficant amount of head loss in your system when you
are adjusting things. If the hydraulic grade line is flat, then you really don't know if the
model is accurate or not. If you are using Darwin calibrator, don't waste your time (and
Darwin's) entering data when the hydraulic grade line slope is flat.
Know the boundary conditions of the system (which pumps are running, what the water
level is in the tank) whenver you are making pressure readings.
Most important thing of all--talk to the operators. Listen and learn from them (but don't
believe everything they tell you).

The multipliers just come from a mass balance

Multipier = (Flow in - flow out +/- change in storge)/ave flow
Develop the multiplier for each hour. To do this you need good flow meter and tank level
data.