Plan Of Work

3. PLAN OF WORK
The present work was carried out to formulate controlled release matrix tablets of
VG. The controlled release matrix tablets were prepared by wet granulation method by
using various polymers. Keeping in view the objectives described above the following
plan of work was adopted.
THE SCHEME OF THE ENTIRE WORK IS LISTED AS FOLLOWS:
1. Standardization of the method and construction of calibration curve for the
estimation of VG.
2. Preformulation studies of drug and polymer by FT IR spectral studies.
Formulation of granules for VG controlled release tablets by using polymers
namely HPMC K- 4M, HPMC E-15 and Guar gum.
3. Evaluation of blend characteristics of granulated mixture of drug and polymers:

Angle of repose.

Determination of bulk density.

Determination of tapped density.

Compressibility index.

Drug Content uniformity test etc.

4. Compression of VG controlled release tablets by using tablet punching machine.

5. Evaluation of physical parameters of VG controlled release tablets:

Hardness

Friability

Weight variation.

Drug Content uniformity test etc.

6. Evaluation of in vitro release characteristics of all formulations by using USP

dissolution apparatus 2 (Paddle).
7. To study the mechanism of drug release by applying kinetic parameter

DEPT. OF PHARMACEUTICS PULLAREDDY INSTITUTE OF PHARMACY

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