PATHOPHYSIOLOGY OF HEAT STROKE

(Correlated with laboratory findings)

Heat exposure
(greater heat production, less heat loss)

Increased core body temperature

Increased metabolism

Stimulate central thermo stat at preoptic

nucleus in anterior hypthalamus
hypoglycemia
Sends efferent signals via
autonomic venous system

Systemic vasoconstrition

Trigger cutaneous vasodilation and

diaphoresis (facilitate heat loss)

Involuntary muscle cramps

Excessive sweating

Exacerbate hyperthermia

Dehydration

rhabdomyolysis

Fluid and electrolyte imbalance

Destruction of myoglobin

Decreased circulating blood vol

Ca binds to
damaged muscles
Decreased renal perfusion

Fe released
hypocalcemia
Free radical formation

Decreased GFR

Increased hemolysis

Highly concentrated urine

hematuria

Dark-colored (tea-colored) urine

hyperchloremia
Body thinks there is presence
of pathogens thus releases
cytokines

hypernatremia

Increased
BUN

Hemoconcentration
(Increased RBC,
Increased Hct)

Damages kidneys

Increased WBC
Proteinuria

Smoky-urine

@farr_awaaaay