Salivary Glands

Fungsi Saliva :

Glandula
Salivaris

Proteksi

: Cairan lumbrikasi, mengandung immuno

globulins dan calcium-binding proteins.

Buffer

: HCO3-, PO4- dan sialin yang mempertahankan

pH ;pertumbuhan microorganisme & pembentu kan
carries lebih menonjol pada pH rendah

Pencernaan :

Melunakkan makanan ; mengandung amylase

Taste

: Ionisasi molekul untuk dirasakan oleh taste buds;

Gustin = pertumbuhan dan pematangan
taste buds
Antimicrobial: Dijumpai Lysozyme, antibodies, dan lactoferrin
(mengikat Fe yang diperlukan bacteria)
Tooth integrity: Calcium & Phosphate meningkatkan kekerasan
enamel setelah terjadi erupsi gigi.

Glandula
Salivaris

Glandula
Salivaris

Glandula
Salivaris

Secretory
End pieces
(acini)

Major Salivary Glands

Intercalated duct
Serous acini

Striated duct

Parotid

Major Salivary Glands

Submandibular/Sublingual

Major Salivary
Glands

Major Salivary
Glands
Myoepithelial cell

Serous acinus

Major Salivary
Glands

Protein3

ClCl-

6
Na+
Na+
2
5

Major Salivary
Glands

Major Salivary
Glands

Major Salivary
Glands
Intercalated duct
Serous acini

Striated duct

Parotid

Major Salivary
Glands

Junctional complexes

Myoepithelial cells

Intercalated duct

Major Salivary
Glands

Na
K;HCO3

ry

Striated duct

la
pil
ca

Basal striations
&
mitochondria

Major Salivary
Glands

Basal Striations

Striated duct

Minor Salivary
Glands
Dibahas dalam topik Oral Mucosa/oral cavity
Banyak mengandung mucous dan
immunoglobulin
dengan sel sel
lymphocyt yang mengelilingi ductus
disepanjang dinding ductus sekretorius

Glandula
Salivaris
INERVASI :
Autonomic innervation to:

Vascular smooth muscle

Myoepithelial cells
Acinar (secretory) cells
Ductal cells

Glandula
Salivaris

Sympathetic & parasympathetic nerves

adrenergic = proteins; cholinergic = water, electroly

Schwann cell

Glandula
Salivaris
Parasympathetic innervation (most prevalent) =

Lebih sering menimbulkan sekresi cairan

Exocytosis dari beberapa sel
Kontraksi myoepithelial cells
vasodilation
dapat mnginduksi re-synthesis

Sympathetic innervation (more intermittently) =

Beraksi terhadap sel yang sama dengan effek k

Tidak memobilisasi cairan
Mungkin meningkatkan exocytosis dari bebera

Glandula
Salivaris
Clinical Aspects:

Oncocytes = epithelial cells with an accumulation of

structurally
altered mitochondria; found in acini and ducts;
may give
rise to neoplasms.
Inflammatory disorders (e.g., mumps) = viral or bacte

Systemic diseases = affect salivary secretions; post-ra

Obstructions = calculi (stones in duct)

Xerostomia = dry-mouth; secretions infections & ca

Painful swallowing