What are factors that influence menstrual cycle?

a. Enzyme Factors
In the proliferative phase estrogen affects the storage of hydrolytic enzymes in the
endometrium, as well as stimulate the formation of glycogen acids and mucopolysaccharides.
Substances latter played a role in the development of the endometrium, especially with the
formation of stroma at the bottom. In the mid-luteal phase synthesis of mucopolysaccharides
stalled, resulting in heightening the permeability of blood vessels that has developed since the
beginning of the proliferative phase. Thus more nutrients flowing into the endometrial stroma as
preparation for ovum implantation in case of pregnancy. If pregnancy does not occur, then with
decreasing levels of progesterone, hydrolytic enzymes are released, because it arises disturbance
in the metabolism resulting in regression endomentrium endometrium and bleeding.
b. Vascular Factors
Start the proliferative phase occurs establishment of a system of vascularization in the
functional layer of the endometrium. On the growth of the endometrium also grow too arteries,
veins. With the regression of endometrial static arise in veins as well as channels that connect it
to the arteries, and eventually necrosis and hemorrhage with hematoma formation of both arterial
and venous.
c. Prostaglandin Factors
The endometrium contains many prostaglandin E2 and F2. with the disintegration of the
endometrium, prostaglandin apart and cause berkontraksinya myometrium as a factor to limit
bleeding at menstruation.