Releast

What is it?

Where does it
happend?

Which physiological
parameters can
change it?

Which pathological
parameters can
change it?

Which are the

consecuences of
those changes?

Absorption

Preparation of the drug for

his administration. When
the drug is free.

The pass of the drug

to the place of
administration to the
blood.

Stomach or intestine.

In the celular
membrane, it
depends on the route
of administration.

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SURFAST CONTACT

no absorption,
therefore there is no effect

How can you solve

Change the administration
the pharmacokinetics
way
changes?

no absorption or
retards the
absorption

Change the
administration way

Distribution
Transport of the drug
into the blood
compartment and its
further penetration in
the tissues.

Metabolism
Biochemical changes
suffered by foreign
substances in the
body to remove is
better.

In the liver, it may

also occur in the
In the blood,
small intestine,
Compartiments
kidney, blood, lung,
adrenal glands,
Age: Newborn. Lower placenta, etc.
plasma protein
binding, more free
drug fraction.
Gestation: Lower
ESPECIE,RAZA,EDAD,
plasma protein
SEXO Y HORMONAS
binding,
more
Reduction
of free
drug fraction.
albumina:
renal,
hepatic failure,
burned, malnutrition.
Increase of albumin:
Hypothyroidism.
Toxicity

Toxicity

Change the time of

administration ,
change de dose
(reduce)

Change the time of

administration ,
change de dose
(reduce)

E
Output of drugs and their metabolites from
the circulatory system to the outside of the
body.

Kidney, lung, and the hepatobiliary system.

Toxicity (the drug stay in the body)

Change the time of administration (depending

of the velocity of the kidney) , change the
dose (reduce)