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Project Instructions: Using the template provided, develop a comprehensive, holistic therapeutics table for a typical patient in your chosen
population [at least 15 therapeutics] and scientific, evidence-based rationale. The following should be included in this document: traditional &
integrative pharmacologic and non-pharmacologic interventions, physiologic explanation of rationale, potential adverse effects for which patients
should be monitored, and the general cost of the therapeutic. References should include current national standards of care for this population and best
practice literature. All references should be current within the past 5 years. Formatting for table and narrative is single-spaced.
Please include the following:
Introduction to the Table of Therapeutics for the chosen population addressing the goals of care and integration of holistic interventions.
10 pharmacologic interventions [traditional, including oxygen and integrative]. Please do not include more than 2 drugs in a specific
category of drugs. Consider medications which are typically used to treat, and stabilize the chronic illness and management symptoms
typical of a patient with the chronic illness.
5 non-pharmacologic interventions with a specific emphasis on integrative therapies
Perspectives from 2 or more interprofessional colleagues
Summary of application of holistic therapeutics to health of chosen population and expected optimal outcomes of care.
Tracy Terrones NURS660
Introduction to Patient Population: It is estimated that in the United States there are 6.5 million adult cerebral vascular accident (CVA) survivors.
More then half of CVAs are caused by uncontrolled hypertension and 80 percent of these CVAs are preventable with proper medical treatment.
Population-specific Goals of Care: Immediate treatment and appropriate interventions help minimize the long-term deficits of a CVA survivor and
improve recovery outcomes. The patients optimum healthy lifestyle post CVA and prevention of a recurrent stroke are the objectives to be
accomplished.
Name of Therapeutic
+Route
+Safe Dose [maximum
24hr dose; daily
dosing; onset/ peak/
duration]
General Mechanism of
Action
[paraphrase in your own
words the physiologic
and/or psychological
basis for therapeutic
action using current
General Cost
of
Therapeutic
[per dose and
monthly cost]
References
[use in-text APA
style references
including
personal
communication
as appropriate]
Classification of
Therapeutic
[therapeutic and
pharmacologic OR
category of nonpharmacologic]
#1 Aspirin (ASA)
Route: Oral
Safe Dose: 160-325 mg
QD within 48 hours of
a CVA, 81-325 mg QD
thereafter
Onset: 5-30 minutes
Peak: 1-3 hours
Duration: 3-6 hours
Classification of
Therapeutic
Analgesic, Nonnarcotic
Anti-inflammatory
Agent
Antiplatelet Agent
Antipyretic
Nonsteroidal Antiinflammatory Drug
(NSAID)
Salicylate
evidence]
General Mechanisms of
Action
Decreasing the platelets
ability to aggregate and
to form a clot in narrow
blood vessels. This
mechanism also helps
decrease the amount of
inflammation
experienced by the blood
vessels. Preventing
inflammation will less
the chances of blood
clots from forming.
Page 2
General Cost
of
Therapeutic
[per dose and
monthly cost]
(Adams, Holland,
& Urban, 2014)
("ASA," 2014)
(CreutzfeldtR,
Holloway, &
Walker, 2012)
(Gengo &Rainka,
2013)
Aspirin 325
mg:
(Vallerand,
$0.49 per dose
Sanoski, &
and $14.70
Deglin, 2015)
per month
#2 Clopidogrel
(Plavix)
Route: Oral
Safe Dose: 75 mg QD
Onset: Within 24 hours
Peak: 3-7 days
Duration: 5 days
following
discontinuation
Classification of
Therapeutic
Antiplatelet Agent
General Mechanisms of
Action
Clopidogrel works as an
inhibitor of platelet
aggregation. This
medication creates a
slippery surface of the
platelet blocking the
receptor site from
activating the GPIIb/IIIa
receptor complex of the
clotting cascade. Thus,
preventing the platelets
from sticking together
and forming a clot.
Page 3
General Cost
of
Therapeutic
[per dose and
monthly cost]
Clopidogrel
75 mg: $6.96
per dose and
$208.80 per
month
Plavix 75mg:
$7.73 per dose
and $232.03
per month
(Adams et al.,
2014)
("ASA," 2014)
(CreutzfeldtR et
al., 2012)
(Gengo &
Rainka, 2013)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
#3 Lisinopril (Prinvil
or Zestril)
Route: Oral
Safe Dose: 10 mg QD,
may be increased up to
20-40 mg QD
Onset: 1 hour
Peak: 6 hours
Duration: 24 hours
Classification of
General Mechanisms of
Action
Lisinopril is an
aggressive inhibitor of
angiotensin-converting
enzyme (ACE) that
prevents
vasoconstriction.
Preventing the hormone
General Cost
of
Therapeutic
(Adams et al.,
2014)
(CreutzfeldtR et
al., 2012)
Lisinopril 10
mg: $0.99 per
dose and
(Gengo &
Rainka, 2013)
("ASA," 2014)
Therapeutic
Antihypertensive
angiotensin I from
becoming angiotensin II
will prevent the blood
vessel from constricting.
$29.70 per
month
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
Hypersensitivity to lisinopril,
any component of the
formulation, or other ACE
inhibitors and ARBs can be
related to the development
angioedema.
#4 Atorvastatin
(Lipitor)
General Mechanisms of
Action
General Cost
of
(Adams et al.,
2014)
Route: Oral
Safe Dose: 10-20 mg
QD, may increase
every 2-4 weeks up to
80 mg QD
Onset: unknown
Peak: unknown
Duration: 20-30 hours
following
discontinuation
Classification of
Therapeutic
Lipid Lowering Agent
Lipitor is administered
for primary and
secondary levels of
prevention for a CVA.
Plaque build up in
vessels can lead to
narrowing of arties and
eventually no blood
flow. It is recommended
by the American Stroke
Association that a
cholesterol medication
be added to therapy as a
preventive measure.
Adverse reactions:
Adverse reaction consist of
muclse cramps/weakness,
medication induced hepatitis,
increased liver enzymes, and
pancreatitis
Drug-drug interactions:
This medication can increase
levels of digoxin and the
patient can become toxic.
Warfarins effect can be
amplified by taking Lipitor at
the same time. Increasing the
patients risk for bleeding.
Drug-food interactions:
Grapefruit juice may increase
levels and risk of
rhabdomyolysis
Outline potential
contraindications for the
therapy
Hypersensitivity to
atorvastatin can cause acute
medication induced hepatitis
and pancreatitis.
Therapeutic
#5 Labetalol
Route: Oral or IV
General Mechanisms of
Action
General Cost
of
Page 6
("ASA," 2014)
[per dose and
monthly cost]
(CreutzfeldtR et
al., 2012)
(Adams et al.,
2014)
Safe Dose:
Oral 100 mg BID up to
400-800 mg QD in
divided doses
IV 20 mg initially,
additional doses 40-80
Q 10 minutes as needed
(not to exceed 300 mg
total dose) or 2 mg/min
infusion (range 50-300
mg total dose required)
Onset:
Oral: 20 min-2 hours
IV: 2-5 minutes
Peak:
Oral: 1-4 hours
IV: 5 minutes
Duration:
Oral: 8-12 hours
IV: 16-18 hours
Labetalol is
administered to the CVA
patient for the treatment
of mild-to-severe high
blood pressure and IV
Labetalol is for severe
hypertension or
hypertensive crisis.
Classification of
Therapeutic
Antianginal,
Antihypertensive
Adverse reactions:
Hypotension, dizziness,
bronchospasms, and anxiety
are possible reactions from
Labetalol. These are side
effects that can be noticed
with patients status post CVA.
Drug-drug interactions:
This medication combined
with other heart rate control
medication and anti
hypertensive can lead to heart
blocks and serious
hypotension. Can also
decrease the desired effect of
anti depressive medications
causing hypertention from as
MAOI therapies.
Drug-food interactions:
Administer with food as
Labetalol serum
concentrations may be
increased if taken with food
Outline potential
contraindications for the
therapy
Hypersensitivity to labetalol is
severe bradycardia or heart
block. Bronchospasms with
Page 7
Therapeutic
("ASA," 2014)
[per dose and
monthly cost]
Labetalol 100
mg tablet:
$0.56 per dose
and $16.98
per month
Labetalol
5mg/ml
solution for
IV: $0.14 per
ml
(CreutzfeldtR et
al., 2012)
(Gengo &
Rainka, 2013)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
asthmatic patients.
General Mechanisms of
#6 Ativan
Action
(Lorazepam)
Ativan depresses the
Route: Oral, IV, IM
central nervous system
Safe Dose:
by an inhibitory
Oral: 1-3 mg 2-3x QD, neurotransmitter. By
up to 10 mg/day
attaching specific
IV: 44 mcg (0.044
benzodiazepine to
mg)/kg (not to exceed 2 receptors of the central
mg)
nervous system creating
IM: 50 mcg (0.05
a calming effect.
mg)/kg (not to exceed 4
mg)
Onset:
Oral: 15-60 min
IV: 15-30 min
IM: 30-60 min
Peak:
Oral: 1-6 hr
IV: 15-20 min
IM: 1-2 hr
Duration:
General Cost
of
Therapeutic
(Adams et al.,
2014)
(CreutzfeldtR et
al., 2012)
Ativan 1 mg
tablet: $21.64
per dose and
$694.20 per
month.
Lorazepam 1
mg tablet:
$0.88 per dose
and $264.48
per month
(Gengo &
Rainka, 2013)
Ativan
2mg/ml
injection:
("ASA," 2014)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
#7 Gabapentin
(Neurontin)
Route: Oral
Safe Dose: 100 mg 3x
QD, titrate weekly by
300 mg/day up to 9002400 mg/day
(maximum: 3600
mg/day)
Onset: rapid
Peak: 2-4 hr
Duration: 8 hr
General Mechanisms of
Action
Mechanism of action is
not known. May affect
transportation of amino
acids to cross and to
steady neuronal
membranes.
Classification of
Therapeutic
Analgesic Adjuncts,
Anticonvulsants, Mood
Stabilizers
NURS660: Clinical Systems Leadership Immersion (Revised 06/29/15)
General Cost
of
Therapeutic
(Adams et al.,
2014)
(CreutzfeldtR et
al., 2012)
Gabapentin
100mg tablet:
$0.53 per dose
and $47.92
per month
(Gengo &
Rainka, 2013)
Page 9
Lorazepam
2mg/ml
injection:
$0.90 per dose
("ASA," 2014)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
depression
Outline potential
contraindications for the
therapy
Hypersensitivity to gabapentin
for the patient can lead to
depression to the CNS and
respiratory system.
#8 Lasix (Furosemide)
Route: Oral
Safe Dose: 40mg BID
Onset: 30-60 min
Peak: 1-2 hr
Duration: 6-8 hr
Classification of
Therapeutic
Diuretic
General Mechanisms of
Action
Lasix stops reabsorption
of sodium and chloride
in the ascending loop of
Henle. It increases renal
excretion of fluid and
electrolytes. This
mechanism makes the
patient void large
volumes of fluid.
Page 10
General Cost
of
Therapeutic
(Adams et al.,
2014)
(CreutzfeldtR et
al., 2012)
Lasix 20 mg
tablet: $0.59
per dose and
$17.74 per
month
(Gengo &
Rainka, 2013)
("ASA," 2014)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
Furosemide
20 mg tablet:
$0.14 per dose
and $4.29 per
month
Outline potential
contraindications for the
therapy
Hypersensitivity to
furosemide can lead to poor
renal function and elevated
levels of creatinine and BUN
#9 Alteplase (t-PA)
Route: IV
Safe Dose: 0.9 mg/kg
(not to exceed 90 mg),
given as an infusion
over 1 hr, with 10% of
the dose given as a
bolus over the 1st min
Onset: 30 min
Peak: 60 min
Duration: unknown
General Mechanisms of
Action
t-PA initiates local
fibrinolysis by attaching
to a fibrin thrombus and
dissolves the clot.
Classification of
Therapeutic
Thrombolytic
General Cost
of
Therapeutic
(Adams et al.,
2014)
(Gengo &
Rainka, 2013)
Alteplase
50mg IV:
$4566.16
(Martin &
Talbert, 2013)
("ASA," 2014)
(Vallerand et al.,
2015)
medications should be
avoided.
Outline potential
contraindications for the
therapy
Active internal bleeding and
prior history of bleeding
complication, hemorrhagic
stroke or GI bleeding. High
INR levels or supra
therapeutic level of Heparin.
(Adams et al.,
2014)
#10 Prozac
(Fluoxetine)
Route: Oral
Safe Dose: 10mg QD in
AM, not to exceed
60mg QD
Onset: 1-4 weeks
Peak: unknown
Duration: 2 weeks
Classification of
Therapeutic
Antidepressant
General Mechanisms of
Action
Prozac inhibits the
neuron serotonin
reuptake in the central
nervous system. Prozac
is known as a selective
serotonin reuptake
inhibitor. This will help
the CVA survivor from
feeling depressed.
General Cost
of
Therapeutic
[per dose and
monthly cost]
Prozac 10mg
capsules:
$10.45 per
dose and
$313.56 per
("ASA," 2014)
(CreutzfeldtR et
al., 2012)
(Gengo &
Rainka, 2013)
(Martin &
Talbert, 2013)
(Vallerand et al.,
2015)
month
Fluoxetine
10mg
capsules:
$2.60 per dose
and $77.95
per month
Outline potential
contraindications for the
therapy
Hypersensitivity can lead to
cardiac complications and can
potentially increase the
patients depression cause the
patient to lead to suicidal
ideations.
#11 Acupuncture
Route: In home,
hospital based, or
acupuncture center
Safe Dose: 20 minutes
2x/week initially
Maximum 24 hr dose:
General Mechanisms of
Action
The ancient Chinese
acupuncture therapy
helps CVA patients using
needlepoints on energy
pathways to correct or
General Cost
of
Therapeutic
[per dose and
monthly cost]
(CreutzfeldtR et
al., 2012)
(Wayne, 2013)
20 minutes
Maintenance dosing:
1x/week or every other
week
improve imbalances.
#12 Meditation
Route: In home,
hospital based, yoga
center mindful class
Safe Dose: 5 minutes
Daily dose: 15 -20
minutes
Maintenance dosing:
Daily
General Mechanisms of
Action
The goal of meditation is
to focus on the present
moment without
thinking. This allows the
body to relax and center
ones self. As a stroke
survivor, accepting the
present moment can be
very difficult and by
silencing internal chatter,
negative thoughts can be
removed.
standard treatment in
China for CVA patients.
It is utilized to assist the
CVA patient with
complications in
language and
swallowing.
$75-150/ visit
Outline potential
contraindications for the
therapy
Fear of needles, financial
status, transportation
Page 14
General Cost
of
Therapeutic
[per dose and
monthly cost]
In home: Free
Yoga Center:
$15/session
(CreutzfeldtR et
al., 2012)
(Fortney, 2012)
#13 Aromatherapy
Route: Topical
Safe Dose: 2-3 drops
Daily dose: PRN
Maintenance dosing:
As desired
#14 Massage
Route: In home,
hospital, or massage
spa
Safe Dose: 30-60
minutes
Daily Dose: N/A
Maintenance Dose:
3x/ week
General Mechanisms of
Action
Essential oils are used
for the CVA patient for
the enhancement of the
body, spirit, and soul.
The special effects of
aromatherapy, is the
attachment of chemical
factors in the oils to the
receptors in the olfactory
gland stimulating the
emotional part of the
brain to help relax.
General Cost
of
Therapeutic
General Mechanisms of
Action
Massage therapy is the
technique of applying
compression to the
muscles and other soft
tissues to help heal and
comfort. It decreases
pain, relaxes muscles,
General Cost
of
Therapeutic
Page 15
(Bagheri-Nesami,
Shorofi, Nikkhah,
Espahbodi, &
Koolaee, 2016)
(CreutzfeldtR et
al., 2012)
Essential oil:
$0.064 per
drop and
$0.19 per 3
drops
Massage: $
(CreutzfeldtR et
al., 2012)
(Lamas, Hagar,
Lindgren, Wester,
& Brulin, 2016)
and maximizes
perfusion.
therapy
Patients that do not like to be
physically touched, financial
status
50-100/ hour
session
General Mechanisms of
Action
Herbal medicines can
help the CVA survivor
with relaxation,
depression, and promote
cerebral reperfusion.
General Cost
of
Therapeutic
Page 16
Herb
consultation:
$30-60 and
Herb cost:
$30-60/ month
(CreutzfeldtR et
al., 2012)
(Gardiner & Low
Dog, 2012)
Summary of application of holistic therapeutics to health of chosen population and expected optimal outcomes of care:
Alternative therapies, such as acupuncture, meditation, aromatherapy, massage, and Chinese herbs can support a CVA survivor patient achieve
optimal healing. Patients and caregivers, surrounding themselves with carefully formulated scents, rejuvenating massages, meditation, and
acupuncture could actually assist a CVA survivors recovery in conjunction with traditional stroke treatment and therapy. Alternative therapy provides
additional benefits and encouragements in patients recovery/rehabilitation from a CVA. As one recovers from a stroke, a life changing event, it is
considerable to explore the world of ancient and modern alternative treatments, if your physician deems it safe. Educating our patients about all the
options and treatments for a CVA survivor will hopefully decrease the reoccurrence of another CVA.
References
Adams, M. P., Holland, L. N., & Urban, C. Q. (2014). Pharmacology for nurses: A pathophysiologic approach (4th ed.). Retrieved from
https://online-statref-com.ezproxy1.library.arizona.edu/Document.aspx?FxId=198&SessionID=227ED2BGKLPKMXNB
American Stroke Association stroke target: Phase two. (2014). Retrieved from http://www.strokeassociation.org/idc/groups/heartpublic/@wcm/@gwtg/documents/downloadable/ucm_470730.pdf
Bagheri-Nesami, M., Shorofi, S. A., Nikkhah, A., Espahbodi, F., & Koolaee, F. (2016). The effects of aromatherapy with lavender essential oil on
fatigue levels in hemodialysis patients: A randomized clinical trial. Complementary Therapies in Clinical Practice, 22, 33-37.
http://dx.doi.org/10.1016/j.ctcp.2015.12.002
Creutzfeldt, C. J., Holloway, R. G., & Walker, M. (2012). Symptomatic and palliative care for stroke survivors. Journal of General Internal
Medicine, 27(7), 853-860. http://dx.doi.org/10.1007/s11606-011-1966-4
NURS660: Clinical Systems Leadership Immersion (Revised 06/29/15)
Page 17
Fortney, L. (2012). Recommending meditation. In D. Rakel (Ed.), Integrative medicine (3rd ed., pp. 873-881). Retrieved from https://wwwclinicalkey-com.ezproxy2.library.arizona.edu/#!/content/book/3-s2.0-B9781437717938000820
Gardiner, P., & Low Dog, T. (2012). Prescribing botanicals. In D. Rakel (Ed.), Integrative medicine (3rd ed., pp. 913-921). [Arizona Health Science
Library]. Retrieved from https://www-clinicalkey-com.ezproxy2.library.arizona.edu/#!/content/book/3-s2.0-B978143771793800087X
Gengo, F. M., & Rainka, M. M. (2013). Pharmacogenomics in neurology. In J. S. Bertino, A. D. Kashuba, J. D. Ma, U. Fuhr, & L. C. DeVane (Eds.),
Pharmacogenomics: An introduction and clinical perspective (Ch. 16). Retrieved from
http://accesspharmacy.mhmedical.com.ezproxy2.library.arizona.edu/content.aspx?bookid=511§ionid=40849385
Lamas, K., Hagar, C., Lindgren, L., Wester, P., & Brulin, C. (2016). Does touch massage facilitate recovery after stroke? A study protocol of a
randomized controlled trial. BioMed Central Complementary and Alternative Medicine, 16(50), 1-9. http://dx.doi.org/10.1186/s12906-0161029-9
Martin, C. P., & Talbert, R. L. (2013). Pharmacotherapy: Bedside guide. Retrieved from Arizona Health Science Library
Vallerand, A. H., Sanoski, C. A., & Deglin, J. H. (2015). Davis drug guide for nurses (14th ed.). Retrieved from https://online-statrefcom.ezproxy1.library.arizona.edu/Document.aspx?
FxId=58&SessionID=227ED2BGKLPKMXNB#H&1&ChaptersTab&N6Gco_9BBDOQaaQ0KDh78Q%3d%3d&&58
Wayne, P. (2013). American Stroke Association evaluating needles: Acupuncture as stroke therapy. Retrieved from
http://www.strokeassociation.org/STROKEORG/LifeAfterStroke/RegainingIndependence/PhysicalChallenges/Evaluating-Needles--Acupuncture-as-Stroke-Therapy_UCM_310767_Article.jsp#.VtOCexjwPhM
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