waktu (jam)

C (mcg/mL) ln C
AUC0-12
0 4.302085908
1.4591 2.922032
0.75
3.49 1.2499017362
0.8425
1
3.25 1.1786549963
2.855
2
2.46 0.9001613499
2.16
3
1.86 0.6205764877
1.63
4
1.4 0.3364722366
1.23
5
1.06 0.0582689081
0.93
6
0.8 -0.2231435513
0.705
7
0.61 -0.4942963218
0.535
8
0.46 -0.7765287895
0.72 12.0175
10
0.26 -1.347073648
0.41
12
0.15 -1.8971199849 0.535427 AUC12-~ Cp12/slope 3ttik trakhir
AUC total
15.47496
Intercept
1.459126981
slope
-0.27990678 kel
1.

Kel
t1/2
Vd
Dosis/Cp0
AUC total
slope 3 titik terakhir
Clearance
Kelx Vd

0.279907 --> harus nya 3 titik terakhir, karena 3 titik te

2.475824
4.648908
15.47496
-0.280148
1.301261

2.

persamaan

ln Cp(t) = -0,2799t + ln 4,302

Cp(t) = 4,302 . e^-0,28.t

3.

0,3 = 4,3.e^-0,28.t
t = 9,511 jam

3ttik trakhir

2
1.5
f(x) = - 0.27990596x + 1.4591207141
R = 0.9999898726

1
0.5
0
-0.5

10

12

14

-1
-1.5
-2
-2.5

rakhir, karena 3 titik terakhir menunjukan proses eliminasi --> 0,28015

Column C
Linear (Column C)

t (jam)

Cp
0.5
1
1.8
4
5.8
8
12
18
24

intercept
slope
Cp (0)

ln C
19.29
17.56
15.1
9.98
7.1
4.7
2.21
0.71
0.23

2.959587
2.865624
2.714695
2.300583
1.960095
1.547563
0.792993
-0.34249
-1.469676

3.054332
-0.188556 Kel.
21.20701

4
3
2
1
0
0

Cp (t) = 21,21.e^(-0,18856t)

-1
-2

10

Column C

10

15

20

25

30