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  • Nstemi: A. Elderly Family History DM Dyslipidemi A Hypertensi On

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    Clint Irvan Brillantes
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    Nonmodifiable risk factors for NSTEMI include older age, dyslipidemia, family history, and hypertension. Rupture of an atherosclerotic plaque exposes thrombogenic tissue which activates the coagulation cascade and platelet activation. This leads to platelet adhesion, aggregation, and transient thrombosis or coronary artery occlusion causing NSTEMI.

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    PATHOPHYSIOLOGY

    Original Title

    BIBEH

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    Nonmodifiable risk factors for NSTEMI include older age, dyslipidemia, family history, and hypertension. Rupture of an atherosclerotic plaque exposes thrombogenic tissue which activates the coagulation cascade and platelet activation. This leads to platelet adhesion, aggregation, and transient thrombosis or coronary artery occlusion causing NSTEMI.

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    © All Rights Reserved
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    10 views1 page

    Nstemi: A. Elderly Family History DM Dyslipidemi A Hypertensi On

    Uploaded by

    Clint Irvan Brillantes
    Nonmodifiable risk factors for NSTEMI include older age, dyslipidemia, family history, and hypertension. Rupture of an atherosclerotic plaque exposes thrombogenic tissue which activates the coagulation cascade and platelet activation. This leads to platelet adhesion, aggregation, and transient thrombosis or coronary artery occlusion causing NSTEMI.

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    © All Rights Reserved
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    of 1

    MODIFIABLE RF:

    DM

    A.

    NSTEMI

    NONMODIFIABLE RF:
    Elderly

    Dyslipidemi
    a

    Family
    History

    Hypertensi
    on

    rupture or ulceration of a vulnerable


    atherosclerotic Plaque

    exposes the highly thrombogenic


    subendothelium to circulating platelets
    and white blood cells (TISSUE FACTOR)

    activates the extrinsic coagulation


    Cascade (Factor VII, and also cleavage of
    factor IX, contribute to activation of

    activated platelets release powerful promoters of


    vasoconstriction and platelet aggregation
    (thromboxane A2, serotonin, adenosine
    diphosphate, and platelet-activating factor)intrinsic

    platelet adhesion and aggregation

    transient thrombosis or subtotal coronary


    artery occlusion with dynamic
    vasoconstriction

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