Chemotherapy for Hematological diseases

Sickle cell anemia Hydroxyurea

Autoimmune (warm or IgG) hemolysis: High dose steroids Rituximab, Azathioprine,
Cyclophosphamide, Cyclosporine
Cold agglutinin: Rituximab +/- Fludarabine
Paroxysmal nocturnal hemoglobinuria Eculizumab
Aplastic anemia Immunosuppression by anti-thymocyte globulin, cyclosporine, and
corticosteroids.
Polycythaemia vera: Hydroxyurea
Essential thrombocytosis: Hydroxyurea, Anagrelide, INF (in pregnant)
Myelofibrosis: Allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative
treatment regimen for PMF.
Supportive treatment: Androgens, Danazol, Hydroxyurea, Thalidomide, prednisone,
Lenalidomide, Etanerecpt, Ruxolitinib.
CML Imatinib
MDS Lenalidomide
CLL Rituximab, Fludarabine, Cyclophosphamide
HCL Cladribine Pentostatin Rituximab
Hodgkin disease: ABVD Adriamycin, Bleomycin, Vincristine, Dacarbazine
There are other regimens.
NHL: CHOP Cyclophosphamide, (Adriamycin), (Vincristive), Prednisone.
Multiple myeloma: High, Intermediate risk: Chemotherapy then hematopoietic cell
transplantation
VRd: bortezomib, lenalidomide, low-dose dexamethasone;
VCd: bortezomib, cyclophosphamide, low-dose dexamethasone
Waldenstrom macroglobulinemia: Plasmapharesis, Rituximab, Bortezomib,
Cyclophosphamide, Dexamethasone
st

ITP:1 line: IVIG, anti-D, or glucocorticoids.

If these standard therapies do not adequately control symptoms: rituximab, or a
thrombopoietin receptor agonist (romiplostim or eltrombopag).
-------------------------------------------------------------------------------------------Lenalidomide MF, MDS, MM.

Revised according to UpToDate

Khaled El-fert