CC CON NG DN

TRUYN VO DA & TC
GVHD
C Vng Ngc Chnh
Nhm 9 Nguyn H Hng Phc
(61303042)
Th Thanh Tho
(61303699)
Nguyn i Vi

NI DUNG
1. S lc v da
2. Cc con ng dn truyn vo da
3. S lc v nang lng v tuyn b
nhn
4. Cc con ng dn truyn qua nang
lng va tuyn b nhn
5. Cc yu t nh hng n qu trnh
dn truyn
2

1. S LC V DA
Da l lp v bc
bao quanh c
th con ngi
Da c gm ba
lp
+ lp biu b
+ lp b
+ lp m
3

LP BIU B

LP BIU B
Lp sng
L lp ngoi cng ca da, dy t
10 20 m
Lp sng cha khong 10-30 lp
corneocyte v mi corneocyte
c dy trung bnh 1 micromet
Cu trc quanh co ny va l
con ng dn truyn ch yu,
va l ro cn u tin cho qu
trnh thm thu hot cht vo
da.
6

LP BIU B
Lp sng
Lp sng cu thnh t
cc t bo sng l nhng
t bo cht c keratin
ho.
Cc t bo ny c kt
dnh vi nhau nh cc
nhm chc lipid dng
bn mng.
7

LP BIU B
Lp sng
Cu trc lamellar gel ca
lp sng l lp mng kp
c sp xp bi cc phn
t phospholipid gm:
Mt u a nc
Mt u k nc
Trong u k nc c
che chn khi mi trng
nc, quay vo nhau to
thnh b khung ca mng
lipid cn u a nc c
nhng vo nc.

LP BIU B
Lp sng
Do hin tng bong da
sinh l, trung bnh mi
ngy c mt lp sng b
thoi ha v gi i, tr
thnh lp t bo cht,
bong ra to nn nhng
vy nh nh vy phn.
Gn 80% cc qu trnh
dn truyn xy ra ti lp
sng
9

2. CC CON NG DN
TRUYN VO DA
Qu trnh thm thuc qua da
Hot cht c phng thch ra khi
t dc
Hot cht s thm qua cc
t chc ca da theo 2 con
ng
ng thm theo
cc b phn ph
Dn truyn
qua tuyn
b nhn

ng trc tip
thm xuyn qua
cc t bo
Dn truyn
qua gian
bo

Dn truyn
xuyn bo
10

11

DN TRUYN QUA GIAN BO

(INTERCELLULAR)
Con ng ny nm gia cc t bo,
xuyn qua lp lipid.

12

13

 Con ng ny chim t 5-30% tng din

tch lp sng.
L hng ro cn tr i vi hu ht phn t.
Nc c thm thu qua da nh dn
truyn gian bo.
Do tnh cht ca lp lamellar gel nn cc
hot cht a du c th i vo c th bng
con ng ny

14

 Vi tnh trng , cc cht tan

trong du nh kem chng nng
v cc cht lin kt vi lp
sng m hp th km hiu qu
vo c th s c ch nh
bng cc cc tc nhn ban u
c nh sn vo lp SC t
mt phng tin chuyn dng
Hu ht cc cht tan i vo c
th qua vng gian bo ca lp
sng c kch thc <0.1mm
S vn chuyn qua da th

15

DN TRUYN XUYN BO
(TRANSCELLULAR)
Hot cht vo da trc tip qua lp sng

Corneocyte dng hnh que hay hnh tr

c trt t
Cholesterol trong lipid gian bo gip cho lp sng
lu ng, khng b ha rn hot cht thm thu
16

3. S LC V TC & TUYN B
NHN

TC
1. Nang tc
2. Thn tc
Tu
V
Tiu biu b

17

Nang tc
Ch chim 0,1%
b mt da.
10-300
nang/cm2
Th tch
khong 0,2
mm3/cm2 b
mt da.
18

TUYN B NHN
Gn ti 2/3 nang
lng.
L ni sinh ra sebum.

19

4. DN TRUYN QUA TUYN B NHN-NANG LNG

20

 Con ng dn truyn ch yu ca
cht i du.
Thi gian tr hoat cht lu hn lp
sng.
Con ng lun m.

21

5. CC YU T NH HNG QU TRNH DN TRUYN

Cc yu t sinh l

La tui, gii tnh v loi da

B dy da cc la tui v gii tnh khc nhau
mc thm thuc qua da khc nhau
Mc v tc thm thuc qua da t l nghch
vi tui tc
Yu t di truyn cng nh hng n kh nng
thm thuc
Da kh: hp thu tt thuc m c t dc thn
du
22

Tnh trng ca da
da nguyn vn: lp sng l hng ro bo
v da
da b tn thng: lp sng b ph hy,
mt kh nng bo v yu t quyt nh
l nng hot cht, din tch v thi
gian tip xc vi hot cht.
23

Nhit ca da
Nhit ti ni bi thuc tng, gim

nht ca mng cht bo, ca t dc trong

thuc, tng tc khuch tn ca hot
cht hot cht thm qua d dng
Nhit lm tng tun hon ca da ti ch

bi nn s hp thu s c tng cng

24

Cc yu t v dc hc
Cc yu t v hot cht
Tnh ha tan v h s phn tn: hot
cht d ha tan c trong nc v trong
du d dng hp thu qua da nht
Nng hot cht: nng hot cht
cng cao, chnh lch nng 2 bn
mng cng ln hp thu cng nhiu
Khi lng phn t hp cht: phn
tnh hp thu d dng
25

Yu t v t dc
Cc cht in hot lm tng tan, lm tng
tnh thm, lm tng hp thu ca cc hot
cht
Cc dung mi: thm dung mi hu c lm
tng tnh thm ca hot cht
Cht lm gim tnh i khng ca lp sng:
lm tng hp th

26

K thut bo ch
K thut bo ch lm nh hng n
trng thi l ha, phn tn hot cht,
th cht ca thuc m nh hng n
mc v tc gii phng ca hot
cht.

27

Nh v thm: dn truyn xuyn bo

Axit L-ascorbic (vitamin C), tocopherol acetate (vitamin
E),retinol (vitamin A).
Ln v khng thm: dn truyn qua gian bo
Cc thnh phn peptide nh matrixyl 3000, l mt cht
c kh nng lm vic khong khng gia cc t bo da.
Ln v khng thm: dn truyn qua tuyn b nhn
v nang lng
Nhm,.
28

TI LIU THAM KHO

HANDBOOK OF COSMETIC SCIENCE AND TECHNOLOGY-Third
Edtion-Edited by Andr O. Barel Marc Paye Howard I. Maibach
DELIVERY OF COSMETIC INGREDIENTS TO THE SKIN Prepared
by: Charlene DeHaven, MD, FACEP, Clinical Director
FOLLICULAR PENETRATION AND TARGETING- Jurgen
Lademann, Nina Otberg, Ute Jacobi, Robert M. Hoffman, and
Ulrike Blume-Peytavi
DELIVERY SYSTEM HANDBOOK OF PERSONAL CARE AND
COSMETC PRODUCT, edited by Meyer R.Rosen
OVERCOMING THE STRATUM CORNEUM:THE MODULATION OF
SKIN PENETRATION (A Review) H. Trommer, R.H.H. Neubert
MECHANISMS, KINETICS AND MATHEMATICAL MODELLING OF
TRANSDERMAL PERMEATION- AN UPDATED REVIEW, Mithun
Bhowmick, Tamizharasi Sengodan
Ti liu ting Vit tham kho t Google
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CM N C & CC BN
LNG NGHE!

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