BIOL4360 S16

Aron Stubbs
Name ______________________

PS15 Assignment

1) Based on the research presented by McIntyre, et al, Hox5 and Hox6 paralogous mutants both resulted in what
phenotype? (2 points)
Ectopic Rib at C7

thoracic vertebral elements

2) The Hox6 mutants showed significant defects in the somite-derived, __________________________________

as well as in the sternum. (1 point)

3) List the 3 signaling centers responsible for the growth and patterning along the proximal/distal,
anterior/posterior, and dorsal/ventral axes. (1 point, no partial credit)

apical ectodermal ridge

the zone of polarizing activity

limb bud ectoderm

4) What are the specific characteristics of each of the two main subtypes of polydactyly? (2 points)

1) presence of extra toes arising from the second phalanx of the most anterior toe
2) extra toe separation originates from the first phalanx