http://GyanKatta.

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Applied Pharmaceutical Structural Bioinformatics (GK 301)

Duration: Flexible 10 weeks
Location for Studies: Flexible (Onsite preferred)
Outline of the course: The course is given through down-loadable documents, audio-visual selfstudies and teacher-supervised exercises that student solves on computer using available software. The
course has no fixed times and the student can carry out their duties at any time of each study week.
This course on Applied Pharmaceutical Structural Bioinformatics intends to teach how to solve
practical problems in pharmacology, life sciences and bioinformatics of your molecule of interest using
free software and databases relating to the structure of functional proteins and drug targets.
The course covers bioinformatics for nucleotide and amino acid sequences and structural
bioinformatics. This includes methods, databases and software for analysis and management of amino
acid and nucleotide sequences, secondary and tertiary structures of proteins, methods and tools for
homology modeling of protein 3D structure, and molecular dynamics simulations and molecular
docking. The focus of the course is on practical exercises where the student solves biophysical
structural problem.
Besides theoretical teachings, course contains the following practical sections:

Data base searching

Pairwise and multiple sequence alignments
Prediction of secondary protein structure
Prediction of protein 3D structure
3D Structure Visualization (PyMol)
Validation of 3D structures
Molecular dynamic simulation
Molecular docking and drug screening (computer-aided drug design)
Generate publication quality images and videos
Build a web page that shows your study research report
Compile and submit your results to a journal for publication

Fee: Rs 5000
Contact: pmc@ManishChandra.Org