NI Medical Innovation Summit

Modena 8 Giugno 2010

Lo sviluppo di uno strumento

biomedicale innovativo
Arrigo Palumbo
e-mail : palumbo@unicz.it
Dipartimento di Medicina Clinica e Sperimentale

Universit Magna Graecia CATANZARO

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 11

 Agenda:

Brain Computer Interface BCI

Fisiologia Neurologica ECMEG (ECG-EMG-EEG)

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 2

 IMMAGINAZIONE DEL MOVIMENTO
Area premotoria Pianificazione dei
movimenti
Corteccia motoria
primaria Esecuzione dei
movimenti
Area motoria
supplementare Immaginazione dei
movimenti

AREA FRONTALE

RITMI MU E BETA
Banda [8-30]Hz
Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 3
 SEGNALE EEG

Prodotto da interazioni
dei potenziali post-
sinaptici di pool di
neuroni corticali
piramidali
Ampiezza decine-
centinaia di V
Posizionamento elettrodi
secondo lo Standard
Internazionale 10/20
Rilevazione
monopolare/bipolare

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 4

 ARCHITETTURA BCI

Signal Signal Pre-

conditioning acquisition processing

APPLICAZIONI Features
Extraction

Features
Classification

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 5

 ARCHITETTURA BCI: CONDIZIONAMENTO
DEL SEGNALE

Signal Signal
conditioning acquisition

EEG AMPLIFIERS

Stadi amplificazione
Filtro passa-banda
Filtro notch
Convertitori A/D
Interfaccia PC

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 6

 ARCHITETTURA BCI: PREPROCESSING

Signal Signal Pre-

conditioning acquisition processing

ARTEFATTI DI
ORIGINE
Riduzione degli artefatti BIOLOGICA
Spatial filtering
ARTEFATTI DI
ORIGINE NON
BIOLOGICA Jaw clenching
Heart rate

Electrode
Contact Power line Eye blink

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 7

 ARCHITETTURA BCI: ESTRAZIONE
DELLE FEATURES

Signal Signal Pre-

conditioning acquisition processing

Stima della densit spettrale di potenza Features

Extraction
(PSD)
Metodi non parametrici
Metodi parametrici

Analisi tempo/frequenza: trasformata

wavelet, Short Time Fourier Transform (STFT)

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 8

 INDEPENDENT COMPONENT ANALYSIS
(ICA)

Stime delle sorgenti

s(t) Wx(t)

A: matrice di mixing;
W: matrice di demixing;

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 9

 EEG FEATURES

Attivit ritmica
Ritmo Frequenza (Hz)
<4
ERD: Desincronizzazione
4-7 evento-correlata
8-13
14-30
ERS: Sincronizzazione
> 30 evento-correlata
8-12

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 10

 EEG FEATURES con Elaborazione ICA
Segnali rilevati dagli elettrodi Componenti estratte dallICA
Fp2 (Channel 1) ARTEFATTO OCULARE

F4 (Channel 2) ARTEFATTO DA POLSO

F8 (Channel 3) ATTIVIT RITMICA

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 11

 EEG MOTORIO
C3 C5

MANO MANO
CHIUSA CHIUSA

C4
MANO
CHIUSA

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 CALL FOR IDEAS - AriSLA 2009
PROGETTO BRINDISYS
(Brain-Interface devices to support individual autonomy in individuals with severe motor deficits)

Fondazione S.Lucia
Universit La Sapienza
Universit di Catanzaro
National Instruments
g.tec
Associazione Crossing Dialogues
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 DIAGNOSI DI NEOPLASIE DEL TRATTO
FARINGEO

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 SET UP DI ACQUISIZIONE

FPGA

HOST

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 SUBJ1 pre-operatorio: Power Spectrum;
Raw Signal; Spectrogram

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 SUBJ1 pre-operatorio: Spectrogram
(zoom)

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 SUBJ1 post-operatorio: Power Spectrum;
Raw Signal; Spectrogram

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 SUBJ1 post-operatorio: Spectrogram
(zoom)

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 SUBJ2 pre-operatorio: Power Spectrum;
Raw Signal; Spectrogram

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 SUBJ2 pre-operatorio: Spectrogram
(zoom)

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 SUBJ2 post-operatorio: Power Spectrum;
Raw Signal; Spectrogram

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 SUBJ2 post-operatorio: Spectrogram
(zoom)

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 SUBJ3 pre-operatorio: Power Spectrum;
Raw Signal; Spectrogram

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 24

 SUBJ3 pre-operatorio: Spectrogram
(zoom)

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 SUBJ3 post-operatorio: Power Spectrum;
Raw Signal; Spectrogram

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 26

 SUBJ3 post-operatorio: Spectrogram
(zoom)

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 SUBJ4 pre-operatorio: Power Spectrum;
Raw Signal; Spectrogram

Presentation_ID 2007 Cisco Systems, Inc. All rights reserved. 28

 SUBJ4 pre-operatorio: Spectrogram
(zoom)

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 SUBJ4 post-operatorio: Power Spectrum;
Raw Signal; Spectrogram

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 SUBJ4 post-operatorio: Spectrogram
(zoom)

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 Grazie per lattenzione

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