C.

Remyelination
In a number of disorders of the peripheral nervous system
(such as the Guillain-Barre syndrome), there is demyelination, which interferes with conduction
(see Chapter 3). This condition is often followed by remyelination by Schwann cells, which are
capable of elaborating new myelin sheaths in the peripheral nervous system. In contrast,
remyelination occurs much more slowly (if at all) in the CNS. Little remyelination occurs within
demyelinated plaques within the brain and spinal cord in multiple sclerosis. A different form of
plasticity (ie, the molecular reorganization of the axon membrane that acquires sodium
channels in demyelinated zones) appears to underlie clinical remissions (in which there is
neurological improvement) in patients with multiple sclerosis.

A Neuropathy
In peripheral neuropathies—diseases affecting peripheral nerves—the conduction velocity of
motor nerves may be reduced, frequently to less than 40 m/s. Conduction block, whereby
impulses fail to propagate past a point of axonal injury, can also occur. The reduction in
conduction velocity can be measured in terms of increased conduction time between nerve
stimulation and muscle contraction and in the longer duration of the muscle action potential.
Slowing in conduction velocity occurs in neuropathies when there is demyelination, such as in
Guillain-Barre syndrome and in some chronic or hereditofamilial neuropathies.
Waxman, S. G. (2010). Guillane-Barre Syndrome. In Clinical Neuroanatomy (26th ed.) (pp. 286, 16, 24).McGraw-
Hill