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  • Iii. Pathophysiology Client Based

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    jean_fabula
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    The document summarizes the pathophysiology of type 2 diabetes mellitus in 3 sentences: Uncontrolled lipolysis in adipose tissue increases free fatty acids in the plasma, suppressing glucose metabolism in skeletal muscle and impairing insulin's action, leading to elevated blood glucose levels. The pancreas produces less insulin and more glucagon, further worsening hyperglycemia and glucose regulation. Over time, tissues become resistant to insulin's effects, blood glucose rises, and the kidneys cannot reabsorb all glucose, causing glycosuria and other symptoms of diabetes.

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    patho -DM

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    The document summarizes the pathophysiology of type 2 diabetes mellitus in 3 sentences: Uncontrolled lipolysis in adipose tissue increases free fatty acids in the plasma, suppressing glucose metabolism in skeletal muscle and impairing insulin's action, leading to elevated blood glucose levels. The pancreas produces less insulin and more glucagon, further worsening hyperglycemia and glucose regulation. Over time, tissues become resistant to insulin's effects, blood glucose rises, and the kidneys cannot reabsorb all glucose, causing glycosuria and other symptoms of diabetes.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views1 page

    Iii. Pathophysiology Client Based

    Uploaded by

    jean_fabula
    The document summarizes the pathophysiology of type 2 diabetes mellitus in 3 sentences: Uncontrolled lipolysis in adipose tissue increases free fatty acids in the plasma, suppressing glucose metabolism in skeletal muscle and impairing insulin's action, leading to elevated blood glucose levels. The pancreas produces less insulin and more glucagon, further worsening hyperglycemia and glucose regulation. Over time, tissues become resistant to insulin's effects, blood glucose rises, and the kidneys cannot reabsorb all glucose, causing glycosuria and other symptoms of diabetes.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    of 1

    III.

    PATHOPHYSIOLOGY
    Client Based:

    Modifiable factor Non-modifiable factor


    -Diet (sweet -Age (49 y/o)
    foods) -Genetics (Maternal)
    - Sedentary -Sex (Female)

    Uncontrolled Autoimmune
    lipolysis in destruction of
    adipose tissue pancreatic B-cells

    Increase level Deficiency in insulin


    of free fatty secretion
    occurs in
    plasma
    Abnormal pancreatic
    Suppress a-cells function
    glucose metab.
    In skeletal
    muscle Desensitization of
    the liber to the levels
    Impairs the of blood glucose
    action of insulin

    Excessive secretion
    of glucagon

    Decrease the
    expression of a
    number of genes
    necessary for target
    tissues to respond to
    Elevated insulin
    plasma glucose

    Capacity of
    kidney to
    absorb glucose
    is surpassed

    glycosuria Increased renal Accompanied of polyuria


    loss of glucose loss of H2O and
    electrolytes
    Negative
    calorie balance
    dehydration

    Increase
    appetite and Activation of
    food intake thirst mechanism

    polyphagi
    polydipsia
    a

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