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VI.

PATHOPHYSIOLOGY

Client based: Hirschsprung’s Disease

Predisposing Factors: Precipitating Factors:


Age Pregnancy
Genetics/ Heredity Other Congenital
Disease

Absence of Ganglion Cells in Myenteric Plexuses

Inadequate expression of PNS stimulation


(lacetylcholinesterase, NO)

Inhibits relaxation of contracted segment

Ineffective peristaltic movement

Bowel distention 2˚ to fecal stagnation and gas

Perforation Constipation
Bacterial Mucosal
Overgrowth Irritation

Enterocolitis and Abdominal Distention


Diarrhea (most common
complication)

Obstruction

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