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In the upper half of the figure, antigen-induced activation of central memory T (TCM) cells (which are CD62L+) results
in the generation of CD62L+ and CD62L- effector cells, which develop into memory T-cell subsets that have the same
pattern of CD62L expression. The level of activation will determine the number of CD62L+ cells that are generated,
with fewer CD62L+ memory T cells generated with increasing activation strength. The lower half of the figure depicts
antigen-induced activation of effector memory T (TEM) cells (which are CD62L-), which results in the production of
only CD62L- effector and secondary memory T cells. CD62L+ TCM cells proliferate more than CD62L- TEM cells, which
results in an increase in the proportion of CD62L+ TCM cells in the overall memory T-cell pool with increasing time
after immunization.