Brand Name: 

PLASIL

CLASSIFICATIONS
Therapeutic: 
Antiemetics
ACTIONS
Physiologic Mechanism
• Decreased nausea and vomiting.
• Decreased symptoms of gastric stasis.
Pharmacologic Mechanism
• Blocks dopamine receptors in chemoreceptor trigger zone of the CNS.
• Stimulates motility of the upper GI tract and accelerates gastric emptying.
INDICATION
• Management of esophageal reflux
• Treatment and prevention of postoperative nausea and vomiting
NURSING CONSIDERATIONS
• Assess patient for nausea, vomiting, abdominal distention, and bowel sounds before and after
administration.
• May cause drowsiness.
• Advise patient to avoid concurrent use of alcohol and other CNS depressant while taking this
medication.
• Advise patient to notify health care professional immediately if involuntary movement of eyes,
face or limbs occurs.