Hla Dictionary 2008

Tissue Antigens ISSN 0001-2815
The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/

4/5, and -DQB1 alleles and their association with serologically
defined HLA-A, -B, -C, -DR, and -DQ antigens
R. Holdsworth1,8,9, C. K. Hurley2,8,10, S. G. E. Marsh3,4,8,10, M. Lau5,8, H. J. Noreen6, J. H. Kempenich7,
M. Setterholm7,10 & M. Maiers7,10
1 Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australia
2 Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
3 Anthony Nolan Research Institute, Hampstead, London, UK
4 UCL Cancer Institute, Royal Free Campus, Hampstead, London, UK
5 UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, Los Angeles, CA, USA
6 Histocompatibility Laboratory, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA
7 National Marrow Donor Program, Minneapolis, MN, USA
8 WHO Nomenclature Committee for Factors of the HLA system
9 Australian Bone Marrow Donor Registry, NSW, Australia
10 Quality Assurance and IT Working Groups, World Marrow Donor Association, Leiden, The Netherlands
Key words Abstract

alleles; antigens; histocompatibility; HLA;
serological equivalents; serology The 2008 report of the human leukocyte antigen (HLA) data dictionary presents
serologic equivalents of HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, and
Correspondence -DQB1 alleles. The dictionary is an update of the one published in 2004. The data
Rhonda Holdsworth, BSc summarize equivalents obtained by the World Health Organization Nomenclature
Victorian Transplantation and
Committee for Factors of the HLA System, the International Cell Exchange,
Immunogenetics Service
Australian Red Cross Blood Service
UCLA, the National Marrow Donor Program, recent publications, and individual
PO Box 354 laboratories. The 2008 edition includes information on 832 new alleles (685 class I
South Melbourne and 147 class II) and updated information on 766 previously listed alleles (577 class I
Victoria 3205 and 189 class II). The tables list the alleles with remarks on the serologic patterns and
Australia the equivalents. The serological equivalents are listed as expert assigned types, and
Tel: 161 3 9694 0379 the data are useful for identifying potential stem cell donors who were typed by
Fax: 161 3 9682 1630
either serology or DNA-based methods. The tables with HLA equivalents are
e-mail: rholdsworth@arcbs.redcross.org.au
available as a searchable form on the IMGT/HLA database Web site (http://
Received 27 October 2008; accepted 7 www.ebi.ac.uk/imgt/hla/dictionary.html).
November 2008
doi: 10.1111/j.1399-0039.2008.01183.x
The 2008 edition of the human leukocyte antigen (HLA) defined alleles can be used to identify potential donors listed
data dictionary is the fifth update; previous versions have in unrelated donor registry databases and umbilical cord
been published in 1997, 1999, 2001, and 2004 (1–4). The banks who have been typed by serology. Although the
HLA data dictionary is aimed at identifying the serological majority of laboratories use DNA-based methods for typing
types associated with each HLA-A, -B, -C, -DRB1, and today, there is a significant number of HLA assignments in
-DQB1 allelic product. The dictionary is a reference to help registries and banks that have been determined by serology-
with the identification of potential hematopoietic stem cell based methods. For example, in the database of almost 7
(HSC) donors. The serologic equivalents of the DNA- million volunteers of the National Marrow Donor Program
ª 2009 John Wiley & Sons A/S Tissue Antigens 73, 95–170 95
HLA alleles and serologic types R. Holdsworth et al.
(NMDP) in the United States, the percent of serologic not expected to alter the antigenic expression. Nonex-
assignments for volunteer donors is still significant, with pressed alleles with unique four-digit designations are in-
45% of the HLA-A and -B loci, 31% of the -C locus, 4% of cluded for completeness. Nonexpressed alleles, which share
the -DRB1 locus, and 37% of the -DQB1 locus assignments a four-digit designation with an expressed allele (e.g.
defined serologically. The availability of serologic equiv- B*15010102N and B*15010101), have been excluded from
alents allows potentially matched volunteers typed by the tables.
serology to be matched to DNA-typed patients. The serologic assignment (third column of Tables 1–6) is
The number of newly identified HLA alleles grows each taken from the HLA Nomenclature report 2004 (6).
year and since the 2004 publication, 832 new HLA alleles Serologic specificities of newly identified alleles are only
have been added, including 235 HLA-A, 310 -B, 140 -C, 116 included when reported by the allele contributors as being
-DRB1, 9 -DRB3/4/5, and 22 -DQB1 alleles. Information identical or very similar to the standard specificity
has also been updated for 766 previously listed alleles associated with the allele group (e.g. A1 associated with
numbering 158 HLA-A, 303 -B, 116 -C, 133 -DRB1, 13 - A*01 alleles). Likewise, the contributor may report an allele
DRB3/4/5, and 43 -DQB1 alleles. This edition of the to be expressed as a serologically variant antigen. Such
dictionary includes all newly defined four-digit alleles information is included in the nomenclature report under
displayed in the IMGT/HLA database (5) to the end of the heading ‘previous equivalents’ and is included here in
July 2007 in Tables 1–6. the ‘Comments’ column of Tables 1–6. In some cases, the
Information for the 2008 edition of the dictionary has serological definition given in the WHO Nomenclature
been contributed from several sources. The World Health Report and displayed in the third column has been derived
Organization (WHO) serological assignment is taken from from the previous versions of the dictionary, as these data
the Nomenclature report 2004 (6) and from data submitted were considered sufficiently compelling to be adopted as the
to the WHO Nomenclature Committee for Factors of the WHO value. Such instances of dictionary-derived WHO
HLA System when a new allele is submitted for consider- values are indicated by a footnote in Tables 1–6.
ation. The International Cell Exchange, UCLA program
provides a unique opportunity to obtain the serologic type
of rare and unusual alleles. Updated information for 335 International Cell Exchange, UCLA
alleles was provided by the Cell Exchange for this dictionary The International Cell Exchange, UCLA provided data
edition. Results are routinely submitted from laboratories showing serologic equivalents for 49 HLA-A, 128 -B, 35 -C,
around the world. Half of the nearly 200 laboratories 88 -DRB1, 8 -DRB3, 3 -DRB4, 5 -DRB5, and 19 -DQB1
actively participating in the Cell Exchange are outside the alleles. The latest HLA class I analysis has been updated
United States, with laboratories in Canada, Europe, the with the inclusion of data from 136 new samples, cells 1185–
Middle East, Africa, Asia, Australia and New Zealand, 1320, from healthy individuals, characterized between
and South America. The serology typing data from this February 2004 and November 2007. Each cell was typed
program continue to enhance the dictionary information. by an average number of 100 laboratories, ranging from
The NMDP data for 454 alleles have been updated with a low of 83 to a high of 118. The parallel typing for HLA-A,
serologic typing information. The 13 IHWS data have been -B, and -C alleles using DNA-based methods was performed
taken from the 2004 edition of the data dictionary. There by an average of 46 laboratories, ranging from 43 to 51
have been no further updates on these data. The artificial reporting results for the monthly studies.
neural network (NN) analysis (7) has been rerun to provide The HLA class II analysis was updated with the typing
valuable data on the most likely serological result for information from 68 B lymphoblastoid cell lines (TER335-
a particular allele. The NN analysis now includes data for 402) from the same time period, February 2004 through
alleles of the HLA-C and -DQB1 loci. In addition, November 2007. Each cell was typed serologically by an
serological typing information has been submitted from average number of 13 laboratories, ranging from a low of 8
expert laboratories. The serology data from all sources have to a high of 18. The parallel typing for HLA-DRB1, -DRB3,
been summarized by the authors in the second column of -DRB4, -DRB5, and -DQB1alleles using DNA-based
Tables 1–6 as the expert assigned type. methods was performed by an average of 80 laboratories,
ranging from a low of 66 to a high of 87.
HLA serologic equivalents have been analyzed in
WHO nomenclature: allele and serologic heterozygous samples only if the other HLA allelic product
assignments would not interfere with the serologic recognition. The
The 2008 edition of the dictionary contains all alleles from associated serologic specificities as reported by the partici-
the IMGT/HLA database in release 2.18.0 July 2007. Only pating laboratories are given with the lowest and highest
the four-digit numbering of alleles is listed in the tables percentage recognition, shown in brackets in column 4 of
because the fifth and sixth digits (silent substitutions) are Tables 1–6.
96 ª 2009 John Wiley & Sons A/S Tissue Antigens 73, 95–170
Table 1 HLA-A alleles and their serologic designationsg
International Cell
Exchange, UCLA NMDP IHWS13 data NN
WHO Cells Assigned Cells Cells Assigned

HLA allele Expert assigned assigned Assigned type [%] tested type [%] tested Assignment tested type >0.55 Comments
R. Holdsworth et al.
A*0101 A1 A1 A1 [98–100] 34a A1 [99] 5612 A1 113 The allele was used
for training of the
NN – A1
A*01010102N Not expressed Null – – – – – – NT
A*0102 A1 A1 – – A1 [95] 129 – – Training – A1
A*0103 A1 A1b A1 [99] 2 A1 [94]c 33 A1 5 Training – A1
cd
A*0104N Not expressed Null – – 1 – – NT
A*0106 A1 – – – A1 [100]c 3 – – A1
A*0107 A1 A1 – – – – – – A1
ª 2009 John Wiley & Sons A/S Tissue Antigens 73, 95–170
A*0108 A1 A1 – – – – – – A1 Normal A1
A*0109 A1 – – – – – – – A1
A*0110 A1 – – – – – – – A1
A*0112 Undefined – – – – – – – Not assignede NN: A1
A*0113 A1 – – – – – – – A1
A*0114 A1 – – – – – – – A1
A*0117 A1 – – – – – – – A1
A*0119 A1 A1 – – – – – – Not assignede NN: A1
A*0120 A1 – – – – – – – A1
A*0121 A1 – – – – – – – A1
A*0123 A1 – – – – – – – A1
A*0124 A1 – – – – – – – A1
A*0125 A1 – – – – – – – A1
A*0126 A1 – – – – – – – A1
A*0201 A2 A2 A2 [99–100] 117a A2 [98] 6315 A2 230 Training – A2
A*02010102L Low A2 Low A2 – – – – – – Identical to A*0201 Significantly reduced
or low cell surface
expression
A*0202 A2 A2 A2 [100]a 7 A2 [81] 859 A2 8 Training – A2 ihw13: variant
serum pattern
A*0203 A203/A2 A203 A2 [99–100]a 10 A2 [64] 472 A203 12 A2 ihw13: very short
A2
A*0204 A2 A2 – – A2 [77] 28 – – A2
HLA alleles and serologic types
97
Table 1 Continued
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A*0205 A2 A2 A2 [100] 5 A2 [81] 462 A2 10 Training – A2

A*0206 A2 A2 A2 [99–100]a 47 A2 [68] 636 A2 24 Training – A2
A*0207 A2 A2 A2 [100]a 15 A2 [80] 135 A2 17 Training – A2
A*0208 A2 A2 – – A2 [100]c 7 – – A2
A*0209 A2 A2 – – A2 [100]c 10 – – A2
A*0210 A210/A2 A210 – – A2 [100]c 10 – – A2
A*0211 A2 A2 A2 [99] 1 A2 [74] 228 A2 17 A2 ihw13: short A2
A*0212 A2 A2 – – A2 [100]c 10 A2 1 A2
A*0213 A2 A2 – – A2 [100]c 17 – – A2
A*0214 A2 A2 – – A2 [100]c 7 – – A2
c
A*0215N Not expressed Null – – – – – NT
A*0216 A2 A2 – – A2 [81]c 16 – – A2
A*0217 A2 A2 – – A2 [73] 51 A2 2 A2
A*0218 A2 A2 – – A2 [100]c 1 – – A2
A*0219 A2 – – – Blank [100]c 1 – – A2
A*0220 A2 A2 – – A2 [100]c 26 – – A2 Normal A2
A*0221 A2 A2 – – – – – – A2
A*0222 A2 A2 – – A2 [100]c 21 – – A2
A*0224 A2 A2 – – A2 [100]c 11 – – A2
A*0225 A2 A2 – – – – – – A2
A*0226 A2 – – – A2 [100]c 3 – – A2
A*0227 A2 – – – A2 [100]c 1 – – A2
A*0228 A2 – – – A2 [100]c 1 – – A2
A*0229 A2 A2 – – A2 [100]c 2 – – A2
A*0230 A2 – – – A2 [100]c 7 – – A2
A*0231 A2 A2 – – – – – – A2
A*0233 A2 – – – A2 [100]c 3 – – A2
A*0234 A2 A2 – – – – – – A2
A*0235 A2 A2 – – A2 [100]c 8 A2 2 A2 Normal A2
A*0236 A2 – – – A2 [100]c 1 – – A2 Normal A2
A*0237 A2 – – – – – – – A2
A*0238 A2 – – – A2 [67], blank [33]c 3 – – A2 Normal A2
A*0239 A2 – – – A2 [100]c 1 – – A2
A*0240 A2 – – – – – – – A2
A*0241 A2 A2 – – – – – – A2
A*0242 A2 A2 – – – – – – A2
Table 1 Continued
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A*0244 A2/blank – – – Blank [100]c 6 – – A2
A*0245 A2 – – – A2 [100]c 2 – – A2
A*0246 A2 A2 – – – – – – A2
A*0247 A2 – – – – – – – A2
A*0248 A2 – – – – – – – A2 A2x9, few A23 1 24
sera reactive
A*0249 A2 A2 – – – – A2 1 A2 Normal A2. The HLA
club cell exchange:
nine laboratories
performing serology
A*0250 A2 A2 – – – – – – A2
A*0251 A2 – – – – – – – A2
A*0252 A2 – – – – – – – A2
A*0254 A2 – – – – – – – A2
A*0255 A2/A28 – – – – – – – Not assignede NN: A2, A28, A69
A*0256 A2 – – – – – – – A2 Short A2
A*0257 A2 – – – – – – – A2
A*0258 A2 – – – – – – – A2
A*0259 A2 A2 – – – – – – A2
A*0260 A2 – – – A2 [100]c 3 – – A2
A*0261 A2 – – – – – – – A2
A*0262 A2 – – – – – – – A2 A2 variant; A2x69
variant
A*0263 A2 – – – A2 [100]c 1 – – A2
cd
A*0264 A2 – – – 1 – – A2
A*0265 A2/A19 A2/19 – – – – – – Not assignede NN: A74
A*0266 A2 A2 – – A2 [100]c 2 – – A2
A*0267 A2 A2 – – – – – – A2
A*0268 A2 A2 – – – – – – A2
A*0269 A2 – – – – – – – A2
A*0270 A2 A2 – – – – – – A2
A*0271 A2 A2 – – – – – – A2
A*0272 A2 A2 – – – – – – A2
A*0273 A2 A2 – – – – – – A2
A*0274 A2 A2 – – – – – – A2
99
Table 1 Continued
100
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A*0275 A2 – – – – – – – A2
A*0276 A2 – – – – – – – A2
A*0277 A2 A2 – – – – – – A2
A*0278 Undefined A2 – – – – – – Not assignede NN: A69, A28

A*0279 A2 A2 – – – – – – A2
A*0280 A2 – – – – – – – A2
A*0281 A2 – – – A2 [100]c 1 – – A2
A*0284 A2 – – – – – – – A2
A*0285 A2 – – – A2 [100]c 1 – – A2
A*0286 A2 – – – – – – – A2
A*0287 A2 – – – – – – – A2
A*0289 A2 A2 – – – – – – A2
A*0290 A2 A2 – – – – – – A2
A*0291 A2 – – – – – – – A2
A*0292 A2 – – – – – – – A2
A*0293 A2 – – – – – – – A2
A*0295 A2 A2 – – – – – – A2
A*0296 A2 – – – – – – – A2
A*0297 A2 A2 – – – – – – A2
A*0299 A2 – – – – – – – A2
A*9201 A2 – – – – – – – A2
A*9202 A2 – – – – – – – A2
A*9203 A2 – – – – – – – A2
A*9204 A2 – – – – – – – A2
A*9205 A2 A2 – – – – – – A2
A*9206 A2 – – – – – – – A2
A*9207 A2 – – – – – – – A2
A*9208 A2 – – – – – – – A2
A*9209 A2 – – – – – – – A2
A*9210 A2 – – – – – – – A2
A*9211 A2 – – – – – – – A2
A*9212 A2 – – – – – – – A2
Table 1 Continued
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A*9214 A2 – – – – – – – A2
A*9215 A2 – – – – – – – A2
A*9216 A2 – – – – – – – A2
A*9217 A2 – – – – – – – A2
A*9218 A2 – – – – – – – A2
A*9219 A2 – – – – – – – A2
A*9220 A2 – – – – – – – A2
A*9221 A2 – – – – – – – A2
A*9222 A2 – – – – – – – A2
A*9223 A2 – – – – – – – A2
A*9224 A2 – – – – – – – A2
A*9226 A2 – – – – – – – A2
A*03010102N Not expressed Null – – – – NT
A*0302 A3 A3 A3 [99–100] 2 A3 [78] 342 A3 3 Training – A3
cd
A*0304 A3 A3 – – 1 – – A3
A*0305 A3/blank A3 – – Blank [100]c 5 Blank 1 A3 ihw13: only reactive
with some A3 1 11
and A3 1 19 1 34
sera; normal A3
A*0306 A3/blank – – – – – A3/blank 1 A3 ihw13: very short A3
A*0307 A3 – – – A3 [75]c 4 – – A3
A*0308 A3 – – – A3 [100]c 4 – – A3
cd
A*0309 A3 – – – 1 A3 1 A3
A*0310 A3/blank – – – – – – – A3 A3 sera negative, only
A3 1 30 1 31 1 33
monoclonal
antibodie positive
A*0312 A3 – – – – – – – A3
A*0313 A3 – – – – – – – A3
A*0314 A3 – – – – – – – A3
A*0315 A3 – – – – – – – A3
A*0316 A3 – – – – – – – A3
A*0317 A3 – – – – – – – A3
101
Table 1 Continued
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A*0318 Undefined – – – – – – – A1
A*0319 A3 – – – – – – – A3
A*0320 A3 A3 – – – – – – A3

A*0322 A3 – – – – – – – A3
A*0323 A3 – – – – – – – A3
A*0324 A3 A3 – – – – – – A3
A*0325 A3 – – – – – – – A3
A*0326 A3 – – – – – – – A3
A*0327 A3 – – – – – – – A3
A*0328 A3 – – – – – – – A3
A*0329 A3 – – – – – – – A3
A*0330 A3 – – – – – – – A3
A*1102 A11 A11 A11 [99] 1 A11 [76] 42 A11 8 A11 ihw13: short A11
A*1103 A11 A11 – – A11 [82]c 17 A11 1 A11
A*1104 A11 A11 A11 [63–69] 2 A11 [75], blank [25]c 8 – – A11 Short A11; normal
A11
A*1105 A11 A11 – – A11 [80]c 5 – – A11 Short A11; 3/31 A11
sera reactive
A*1106 A11 – – – A11 [100]c 2 – – A11
A*1107 A11 A11 – – – – – – A11 Normal A11
A*1108 A11 A11 – – – – – – A11 Short A11
A*1109 A11 A11 – – A11 [100]c 1 – – A11
A*1110 A11 A11 – – Blank [100]c 1 – – A10
A*1112 A11 A11 – – A11 [100]c 3 – – A11 Normal A11
A*1113 A11 A11 – – – – – – A11 Short A11
A*1114 A11 A11 – – – – – – A11 Short A11, like A11.2
A*1115 A11 A11 – – – – – – A11
A*1116 A11 – – – – – – – A11
A*1119 A11 A11 – – – – – – A11
A*1120 A11 – – – – – – – A11
A*1122 A11 – – – – – – – A11
Table 1 Continued
International Cell

A*1123 A11 – – – – – – – A11

A*1124 A11 – – – – – – – A11
A*1125 A11 A11 – – – – – – A11
A*1126 A11 – – – – – – – A11
A*1127 Undefined – – – – – – – Not assignede NN: A11, A1
A*1128 A11 – – – A11 [100]c 1 – – A11
A*1129 A11 – – – – – – – A11
A*1130 A11 – – – – – – – A11
A*1131 A11 – – – – – – – A11
A*1132 A11 – – – – – – – A11
A*2301 A23 A23(9) A23 [95–100]a 29 A23 [95], A24 [1] 5119 A23 42 Training – A9, A23
A*2302 A23 – – – A23 [100]c 5 – – A23
A*2303 A23 – – – A9 [100]c 1 – – A23
A*2304 A23 A23(9)b – – – – A23 1 A23 ihw13: short A23,
negative with A9 1
80 (11) sera
A*2305 A23 – – – A23 [100]c 2 – – A23
A*2306 A23 – – – – – – – A23
A*2309 A23 – – – – – – – A23
A*2310 A23 – – – – – – – A23
A*2312 A23 A23(9) – – – – – – A23
A*2313 A23 – – – – – – – A23
A*2314 A23 – – – – – – – A23
A*2315 A23 – – – – – – – A23
A*2316 A23 – – – – – – – A23
A*2402 A24 A24(9) A24 [97–100] 99a A24 [97], A2403 [1] 3098 A24 146 Training – A9, A24
A*24020102L Low A24 Low A24(9) A24 [0–5]a 3 – – Blank 1 Identical to A*2402 Significantly reduced
or low cell surface
expression
A*2403 A2403/A24 A2403 A24 [66–68], A2403 10 A24 [55], blank [20], 282 A24 5 A24 ihw13: short A24,
[29–31]a A9 [4], A2403 [1] negative with A9 1
80 (11) sera
A*2404 A24 A24(9) – – A24 [62], blank [25], 8 – – A9
A2403 [13]c
103
Table 1 Continued
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c
A*2405 A9 A9 A23 [67–70], A24 2 A24 [45], A23 [50] 20 – – A24
[14–19]a
A*2406 A24 A24(9) – – A24 [67], blank [33]c 3 A24 5 A24
A*2407 A24 A24(9) A24 [99–100]a 21 A24 [59] 320 A24 17 Training – A9, A24
A*2408 A24 A24(9) – – A24 [47], blank [26] 30 – – A24 Short A24, similar to
A2403
A*2409N Not expressed Null – – Blank [100]c 2 – – NT
A*2410 A2403/A24 A2403 – – A24 [42], A9 [9], blank 32 A24 1 A24 A2403; ihw13: short
[16], A2403 [3] A24
A*2411N Not expressed Null Blanka 1 Blank [100]c 2 – – NT
cd
A*2413 A24 A24(9) – – 1 – – A24
A*2414 A24 A24(9) – – A24 [82]c 11 – – A24
c
A*2415 A24 – – – – – – A24
A*2417 A24 A24(9)b – – A24 [82]c 11 A24 3 A24 ihw13: short A24
A*2418 A24/A3 A24(9)/A3 – – – – – – A9f A2403x3; short A24
with most A3 and
A9 reactive; NN:
A24
A*2419 A9 A9 – – – – – – A24 Very short A9
A*2420 A24 A24(9)b – – A24 [100]c 9 A24 1 A24
A*2421 A24/A9 A24(9) – – – – – – A24 A9variant; A24 sera
negative
A*2422 A24 A9 – – A24 [83]c 6 A24 1 A24 ihw13: short A24,
negative with A9 1
80 (11) sera; A2403
like
A*2423 A24 A2403 – – A24 [100]c 11 – – A24 A2403
A*2424 A9 – – – – – – – A9f NN: A23
A*2425 A24 – – – A24 [100]c 13 – – A24
A*2426 A24 – – – A24 [100]b 2 – – A24
A*2427 A24 A24(9)b – – – – A24 1 A24 ihw13: short A24
A*2428 A9 A24(9) – – A24 [50], A9 [50]c 2 – – Not assignede NN: A9, A24, A2
A*2429 A24 – – – A24 [100]c 1 – – A24
A*2430 A24 – – – – – – – A24
A*2431 A24 – – – – – – – A24
A*2432 A24 – – – A24 [100]c 4 – – A24
A*2433 A2403/A24 A2403 A24 [99–100]a 4 A24 [100]c 4 A24 1 A24 A2403
Table 1 Continued
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A*2434 A24 – – – – – – – A24

A*2435 A24 – – – – – – – A24
A*2437 A24 A24 A24 [94–97]a 4 A24 [100]c 1 – – A24
A*2438 A24 – – – – – – – A24
A*2439 A24 – – – – – – – A24
A*2441 A24 – – – – – – – A24
A*2442 A24 – – – – – – – A24
A*2443 A24 A24(9) – – – – – – A24
A*2444 A9 – – – – – – – A9f NN: A24
A*2446 A24 – – – – – – – A24
A*2447 A24 – – – – – – – A24
A*2449 A24 – – – – – – – A24
A*2450 A24 – – – – – – – A24
A*2451 A24 – – – – – – – A24
A*2452 A24 – – – – – – – A24
A*2453 A24 – – – – – – – A24
A*2454 A24 – – – – – – – A24
A*2455 A24 – – – – – – – A24
A*2456 A24 – – – – – – – A24
A*2457 A24 – – – – – – – A24
A*2458 A24 A24(9) – – – – – – A24
A*2459 A24 – – – – – – – A24
A*2461 A24 – – – – – – – A24
A*2462 A24 – – – – – – – A24
A*2463 A24 – – – – – – – A24
A*2464 A24 – – – – – – – A24
A*2465 A24 – – – – – – – A24
A*2466 A24 – – – – – – – A24
A*2467 A24 – – – – – – – A24
A*2468 A24 – – – – – – – A24
A*2469 A24 – – – – – – – A24
A*2470 A24 – – – – – – – A24
105
Table 1 Continued
106
International Cell

A*2471 A24 – – – – – – – A24

A*2472 A24 – – – – – – – A24
A*2473 A24 – – – – – – – A24
A*2474 A24 – – – – – – – A24

A*2475 A24 – – – – – – – A24
A*2476 A24 A24(9) – – – – – – A24
A*2477 A24 – – – – – – – A24
A*2478 A24 A24(9) – – – – – – A24
A*2479 A24 – – – – – – – A24
A*2501 A25 A25(10) A25 [94–99] 6a A25 [95], A10 [2] 1375 A25 18 Training – A10, A25
A*2502 A25 A25(10)b – – A25 [88]c 8 A25 1 A25 Normal A25
A*2503 A25 – – – A25 [100]c 2 – – A25
A*2504 A25 – – – – – – – A25
A*2505 A25 – – – A2 [100]c 1 A25
A*2506 A25 – – – – – A25
A*2601 A26 A26(10) A26 [95–97]a 27 A26 [97], A10 [2] 1730 A26 47 Training – A10, A26
A*2602 A26 A26(10) A26 [91–97]a 3 A26 [81] 31 A26 2 Training – A10, A26
A*2603 A26 A26(10) A26 [92–98]a 11 A26 [68], A10 [8] 38 A26 5 Training – A10, A26 ihw13: short A26
A*2604 A26 A26(10) – – A10 [50], blank [50]c 2 – – A26
A*2605 A26 A26(10) – – A26 [90], A25 [10]c 10 – – A26
A*2606 A26 A26(10) – – A26 [100]c 1 – – A26
A*2607 A26 A26(10) – – A26 [100]c 1 – – Not asssignede NN: A43, A10, A26
A*2608 A26 A26(10) – – A26 [95] 65 A26 3 A26 ihw13: short A26,
similar to A*2603;
normal A26
A*2609 A26 A26(10)b – – A26 [33], A10 [33], 3 A26 2 A26 ihw13: short A26
A34 [33]c
A*2610 A10 A10 – – – – – – A26 Short A26, A10
variant
A*2612 A26 – – – A26 [75], A34 [25]c 4 – – A26
A*2613 A26 – – – A26 [100]c 3 – – A26 NN: A66
A*2614 A26 – – – – – – – A26
A*2615 A10 A10b – – – – A10 2 A26 ihw13: only few A10
sera reactive, may
be typed as blank; A
blank
Table 1 Continued
International Cell

A*2616 A26 – – – A26 [100]c 1 – – A26

A*2617 A26 – – – – – – – A26
A*2618 A10 – – – Blank [100]c 1 – – A10f NN: A26
A*2620 A26 – – – – – – – A26
A*2621 A26 – – – – – – – A26
A*2622 A26 A26(10) – – – – – – A26
A*2623 A26 A26(10) – – – – – – A26
A*2624 A26 – – – – – – – A26
A*2626 A26 A10 – – – – – – A26
A*2627 A26 – – – – – – – A26
A*2628 A26 – – – – – – – A26
A*2629 A26 A26(10) – – – – – – A26
A*2630 A26 – – – – – – – A26
A*2631 A26 – – – – – – – A26
A*2632 A26 – – – – – – – A26
A*2633 A26 – – – – – – – A26
A*2634 A26 – – – – – – – A26
A*2635 A26 – – – – – – – A26
A*2901 A29 A29(19) A29 [98]a 1 A29 [96] 115 A29 10 Training – A29
A*2902 A29 A29(19) A29 [98–100]a 17 A29 [99] 1488 A29 28 Training – A29
A*2903 A29 – – – A29 [100]c 4 – – A29
A*2904 A29 – – – A29 [100]c 1 – – A29
A*2905 A29 – – – – – – – A29
A*2906 A29 – – – – – – – A29
A*2907 A29 – – – – – – – A29
A*2909 A29 – – – – – – – A29
A*2910 A29 A29(19) – – A29 [100]c 2 – – A29
A*2911 A29 – – – – – – – A29
A*2912 A29 – – – – – – – A29
A*2915 A29 – – – – – – – A29
A*2916 A29 A29(19) – – – – – – A29
107
Table 1 Continued
108
International Cell

a
A*3001 A30 A30(19) A30 [97–100] 25 A30 [89], A31 [3], 2895 A30 28 Training – A30
blank [3], A19 [1]
A*3002 A30 A30(19) A30 [96–100]a 17 A30 [93], A31 [2], 2124 A30 25 Training – A30
A19 [1]
A*3003 A30 A30(19) – – A30 [83], blank [17]c 6 – – A30
cd
A*3006 A30 – – – 1 – – A30
A*3007 A30 – – – A30 [100]c 2 – – A30
A*3008 A30 – – – – – – – A30
A*3009 A30 – – – A30 [100]c 3 A30 1 A30 ihw13: very short
A30, only broad
A19 sera reactive
A*3010 A30 – – – A30 [100]c 10 – – A30
A*3011 A30 A30(19) – – – – – – A30
A*3012 A30 – – – – – – – A30
A*3013 A30 – – – – – – – A30
A*3014L A30 Low A30(19) – – – – – – A30 Significantly reduced
or low cell surface
expression
A*3015 A30 A30(19) – – – – – – A30
A*3016 A30 – – – – – – – A30
A*3017 A30 A30(19) – – – – – – A30
A*3018 A30 A30(19) – – – – – – A30
A*3019 A30 – – – – – – – A30
A*3020 A30 – – – – – – – A30
A*3021 A30 – – – – – – – A30
A*3022 A30 – – – – – – – A30
A19 [1]
A*3102 A31 A31(19)b – – A31 [100]c 17 – – A31
A*3103 A31 – – – A31 [100]c 2 – – A31
A*3104 A31 A31(19) – – – – – – A31
A*3105 A31 A31(19) – – – – – – A31
A*3106 A31 – – – – – – – A31
A*3107 Undefined – – – – – – – Not assignede NN: A32, A23, A9
Table 1 Continued
International Cell

A*3108 A31/A24 – – – A32 [100]c 1 – – Not assignede A31x24; previously

A*2416; NN: A23,
A9, A32
A*3109 A31 – – – A31 [100]c 3 – – A31 Bw4 motif present
A*3110 A31 A31(19) – – – – – – Not assignede NN: A32
A*3111 A31 – – – – – – – A31
A*3112 A31 A31(19) – – – – – – A31
A*3113 A31 – – – – – – – A31
A*3115 A31 – – – – – – – A31
A*3116 A31 – – – – – – – A31
A*3117 A31 – – – – – – – A31
A*3118 A31 – – – – – – – A31
A*3202 A32 A32(19) – – A32 [100]c 3 – – Not assignede NN: A32
A*3203 A32 – – – A32 [67], blank [33]c 3 – – A32
A*3204 A32/A3 – – – A3 [75], A19 [13], 8 A‘3204’ 1 Not assignede A3 with most A32
A32 [13]c sera reactive
(ihw13); NN: A32,
A3
A*3205 A32 – – – – – – – A32
A*3206 A32 – – – – – – – A32
A*3207 A32 – – – A32 [100]c 1 – – A32
A*3208 A32 – – – A32 [100]c 2 – – A32
A*3209 A32 – – – – – – – A32
A*3210 A32 – – – – – – – A32
A*3211Q A32 – – – – – – – A32 Not expected to be
expressed
A*3212 A32 – – – – – – – A32
A*3213 A32 – – – A32 [100]c 1 – – A32
A*3214 A32 A32(19) – – – – – – A32
A*3215 A32 – – – – – – – A32
A*3301 A33 A33(19) A33 [97–100] 10a A33 [87], A19 [3], 687 A33 19 Training – A33
blank [4]
A*3303 A33 A33(19) A33 [95–100]a 36 A33 [95], A34 [1] 887 A33 27 Training – A33
A*3304 A33 – – – A33 [50], blank [50]c 2 – – A33
A*3305 A33 A33(19) – – A33 [92]c 13 A33 1 A33 ihw13: short A33
109
Table 1 Continued
110
International Cell

cd
A*3306 A33 – – – 1 – – A33
A*3307 A33 – – – – – – – A33
A*3308 Undefined A33(19) – – – – – – Not assignede NN: A31, A33
A*3309 Undefined A19 – – – – – – Not assignede NN: A31, A33

A*3310 A33 – – – – – – – A33
A*3311 A33 – – – – – – – A33
A*3312 A33 – – – – – – – A33
A*3401 A34 A34(10) A34 [93–98]a 30 A34 [67], A26 [10], 269 A34 25 Training – A10, A34 ihw13: distinct
A10 [5], A66 [4], pattern from
A33 [2], blank [7] A*3402
A*3402 A34 A34(10) A34 [92–95]a 11 A34 [89], A33 [4], A26 996 A34 11 Training – A10, A34 ihw13: distinct
[3], A10 [2] pattern from
A*3401
A*3403 A34 – – – – – – – A34
A*3404 A34 A34(10) – – – – A34 2 A34 ihw13: short A34,
with some A11 and
A19 sera reactive;
A34 variant with
some A10 sera
reactive
A*3405 A34 – – – – – – – A34
A*3406 A10 – – – – – A10f NN: A34
A*3407 A34 – – – – – A34
A*3408 A34 – – – A10 [100]c 1 A34
A*3601 A36 A36 A36 [85–93], A1 [5–8]a 5 A36 [68], A1 [16], 807 A36 7 Training – A36
blank [6]
A*3602 A36 – – – – – – – A36
A*3603 A36 A36 – – – – – – A36
A*3604 A36 A36b – – – – A36 2 A36
A*4301 A43 A43 – – A26 [50], A10 [13], 8 – – Training – A43
A34 [13], A19 [13],
blank [13]c
Table 1 Continued
International Cell

A*6601 A66 A66(10) A66 [37–59], A‘6601’ 14 A26 [61], A66 [20], 799 A66 19 Training – A10, A66 ihw13: A‘6601’
[22–42], A26 [15– A34 [8], A10 [3], pattern – different
18], A10 [2–7]a A25 [1] from A‘6602’;
reactive with A34 1
66 sera
A*6602 A66 A66(10) A‘6602’ [35–65], 8 A66 [38], A34 [27], 205 A66 2 A66 ihw13: A‘6602’, short
A66 [15–42], A34 A10 [10], A74 [5], A66
[7–18], A10 [4]a A26 [4]
A*6603 A10 A10 – – A66 [32], A34 [18], 28 – – A10f Short A10; NN: A26
A10 [7], A26 [7]
A*6604 A66 – – – – – – – A66
A*6605 A26 – – – A26 [100]c 1 – – A26
A*6606 A66 A66(10) – – – – – – A66
A*6801 A68 A68(28) A68 [53–68], A28 34 A28 [63], A68 [27] 2736 A68 49 Training – A28, A68
[31–45]a
A*6802 A68 A68(28) A68 [55–65], A28 15 A28 [72], A68 [19], 2327 A68 18 Training – A28, A68
[32–43]a A69 [1]
A*6803 A68 A68(28)b A68 [47–66], A28 16 A28 [63], A68 [28] 202 A68 4 A68
[34–48]a
A*6804 A68 A68(28) – – A28 [75], A68 [25]c 4 – – A68
A*6805 A68 A68(28) – – A28 [53], A68 [29] 59 A28 1 A68 ihw13: possibly A68,
but cell also A2
positive
A*6806 A68 – – – A28 [50], A68 [50]c 2 – – A68
A*6807 A68 – – – Blank [100]c 1 – – A68
A*6808 A68 A68(28) A68 [38–45], A28 [53] 2 A28 [100]c 2 – – A68
A*6809 A68 – – – A68 [100]c 1 – – A68
A*6810 A68 A28b – – Blank [50], A1 [50]c 2 A28 1 A68 ihw13: possibly A68,
but cell also A2
positive
A*6812 A28 A28 – – A28 [50], blank [50]c 6 – – A68 Short A28
A*6813 A68 – – – – – – – A68
A*6814 A68 – – – – – – – A68
A*6815 A68 – – – – – – – A68
A*6816 A68 A68(28) – – – – – – A68
111
Table 1 Continued
112
International Cell

b c
A*6817 A68 A28 – – A28 [100] 1 A28 1 A68 ihw13: possibly A68,
but cell also A2
positvie

A*6819 A68 – – – A28 [100]c 1 – – A68
A*6820 A68 – – – – – – – A68
A*6821 A68 – – – – – – – A68
A*6822 A68 – – – – – – – A68
A*6823 A68 – – – A68 [100]c 1 – – A68
A*6824 A68 – – – – – – – A68
A*6825 A68 – – – A28 [100]c 1 – – A68
A*6826 A68 A28 – – – – – – A68
A*6827 A68 – – – – – – – A68
A*6828 A68 – – – – – – – A68
A*6829 A68 – – – – – – – A68
A*6830 A68 – – – – – – – A68
A*6831 A68 – – – – – – – A68
A*6832 A68 – – – – – – – A68
A*6833 A68 A68(28) – – – – – – A68
A*6834 A68 – – – – – – – A68
A*6835 A68 – – – – – – – A68
A*6836 A68 A68(28) – – – – – – A28f NN: A68
A*6837 A68 – – – – – – – A68
A*6838 A68 – – – – – – – A68
A*6839 A68 – – – – – – – A68
A*6840 A68 – – – – – – – A68
A*6901 A69 A69(28) A69 [40–70], A28 3 A28 [56], A69 [7], 289 A69 6 Training – A28, A69
[33–49]a A2 [6], A68 [3]
blank [36]
A*7402 A74 A74(19) – – Blank [50], A74 [17], 6 – – A74
A33 [17], A31 [17]c
A*7403 A74 A74(19) A74 [89–91] 5 Blank [72], A74 [17] 29 A74 4 A74
A*7404 A74 – – – A74 [100]c 1 – – A74
A*7405 A74 – – – Blank [100]c 1 – – A74
A*7406 A74 A74(19) – – A74 [100]c 1 A74 1 A74
A*7407 A74 A74(19) – – – – – – A74
A*7408 A74 – – – – – – – A74
R. Holdsworth et al. HLA alleles and serologic types
ihw13: difficult to type

National Marrow Donor Program
Updated NMDP data. In some cases, the information reported in previous dictionaries has changed. Cells have been excluded from this study in some cases because their HLA typing has changed.
next to A1 or A24
Assignments made using the expectation
maximization algorithm
Comments
NN: A74
The 2008 data set includes only those typings from US
volunteer donors where both serologic and allele-level results
have been reported for the HLA-A, -B, -C, -DRB1, or -DQB1
loci. As in past versions of the dictionary, the expectation
maximization (EM) algorithm was used to obtain the cor-
Training – A80
Not assignede
relation between alleles and serologic assignments. Readers

type >0.55
are referred to previous versions of the dictionary that des-

Assigned
cribe the use of the EM algorithm and the nuances of the data.
A74
A74
NN
NT
In this version, data for alleles serologically typed in 20 or

more donors (cells tested) have not been updated and
tested
NT, not tested; NN, neural network; HLA, human leukocyte antigen; WHO, World Health Organization; NMDP, National Marrow Donor Program.
Cells
remain the same as that shown in the 2004 dictionary (4).

9
–
For these alleles, we believe that adequate data have been

IHWS13 data
accumulated to define the serologic assignments.

Assignment
A subset of the EM data including the alleles with counts of

less than 20 in the last dictionary version plus newly described
A80
alleles was analyzed. The EM algorithm provides an unbiased

–
assignment of serologic specificities using information from

tested
Cells
all cells carrying the allele in question. In addition, experts

505
3
1
–
–
reviewed the serologic assignments for all cells carrying an

allele in this category and assigned serologic specificities.
Blank [77], A80 [10],
If a primary specificity is provided by the NN, other specificities >0.4 are shown in the comments column.
A74 [33], A33 [33],
Uninformative cells were eliminated and known serologic

A36 [2], A1 [1]
cross-reactivity was considered in the assignment. The

blank [33]c
information from the EM algorithm and the results from

Assigned
type [%]
NMDP
the review were compared and final serologic assignments

were made. The table shows the predicted serologic assign-
cd
–
–
ments and the percent of informative individuals carrying

tested
those assignments. The percentages listed in the table are

Cells
11
derived from the review of typings as described above; this

–
–
–
–
differs from previous years in which the percentages were

derived from the EM algorithm. This change will better
Assigned type [%]
A80 [68–88], A36

Exchange, UCLA
International Cell
reflect the serologic assignment of these less frequent alleles.

In the EM algorithm, percent assignments are skewed by cells
carrying a second more common allele with the same
Not assigned; see comment column for predictions >0.20.
[0–3]
The allele has been identified but serology not informative.
serologic assignment. For example, cells carrying both

–
–
–
–
A*0201 and A*0208 frequently appear. The EM assignment

is influenced by the more common A*0201 allele resulting in
a lower percent assignment for A*0208 (78%). Expert review
assigned
Updated International Cell Exchange, UCLA.

WHO assignment based on dictionary data.
WHO
eliminated these uninformative cells (i.e. carrying both

A80
Null
A*0201 and A*0208) resulting in an A2 assignment for

–
–
–
A*0208 of 100%.
Expert assigned
Not expressed
The information for 454 alleles, including 122 HLA-A,

Undefined
200 -B, 50 -C, 73 -DRB1, and 9 -DQB1, was reviewed and

updated. The reviewed and updated alleles are indicated by
A74
A74
A80
a footnote in the tables. If an allele appears five times or less,

Table 1 Continued
the serologic assignment(s) should be considered as only an

Ref 13–28, 61.
approximation of the serologic reactivity of the resultant

HLA allele
antigen. It should be noted that the number of individuals

A*7412N
A*7409
A*7410
A*7411
A*8001
carrying each allele shown in the tables might not be the

total number of volunteer donors carrying the allele in the
b
g
a
Table 2 HLA-B alleles and their serologic designationsg
114
International Cell Exchange, UCLA NMDP IHWS13 data NN
Expert WHO Cells Cells Assigned

HLA allele assigned assigned Assigned type [%] Cells tested Assigned type [%] tested Assignment tested type >0.55 Comments
B*0702 B7 B7 B7 [98–100]a 32 B7 [98] 10,841 B7 83 Training – B7

B*0703 B703/B7 B703 – – B7 [94]b 17 B703, B7, blank 1 B7 Short B7, B7 1 42
sera reactive, B7 1
22 sera negative
B*0704 B7 B7 – – B7 [89] 44 B7 2 Training – B7

B*0705 B7 B7 B7 [91–97]a 4 B7 [95] 42 B7 6 Training – B7
B*0706 B7 B7 B7 [94–95] 4 B7 [96] 23 – – B7
B*0707 B7 B7 – – B7 [93]b 15 – – B7
B*0708 B7 B7c – – – – B7 1 B7 Short B7, negative
with B7 1 22 sera,
similar to B703
B*0709 B7 B7 B7 [97–98] 2 B7 [100]b 8 B7 2 B7
B*0710 B7 B7c – – B7 [92]b 12 B7 2 B7
B*0711 B7 B7 – – – – – – B7
B*0712 B7 B7c – – B7 [100]b 5 – – B7
B*0713 B7/blank – – – Blank [100]b 3 – – B7
B*0714 B7 B7c – – B7 [100]b 10 B7 1 B7
B*0715 B7 B7 – – B7 [100]b 1 – – B7 B7 variant, some Bw6
sera negative
B*0716 B7 B7 – – B7 [50], B60 [50]b 2 – – B7 Short B7, few B7 sera
reactive, similar to
B703
B*0717 B7 B7 – – – – – – B7
B*0718 B7 – – – – – – – B7
B*0719 B7/42 – – – B42 [100]b 1 – – B42 Short B7
B*0720 B7/blank – – – – – – – B7 Short B7, B7 sera
negative, B7 1 42
sera reactive
B*0721 B7 – – – B7 [100]b 1 – – B7
B*0722 B7 – – – – – – – B7
bd
B*0723 B7 – – – 1 – – B7
B*0724 B7 B7 – – – – – – B7 B7 weakly expressed,
reactive with B7 1
27 (140) sera
B*0725 B7 – – – – – – – B7
B*0726 B7 B7 – – B7 [100]b 1 – – B7 Normal B7
B*0727 Undefined – – – – – – – Not assignede NN: B7
B*0728 B7 – – – – – – – B7
Table 2 Continued

B*0729 B7 – – – – – – – B7
B*0730 B7 B7 – – – – – – B7 B7 variant
B*0731 B7/B42 B7/B42 – – – – – – B7 B7x42, short B7
B*0732 B7/blank – – – – – – – B7 B blank
B*0733 B7 – – – B7 [100]b 1 – – B7
B*0734 B7 – – – – – – – B7
B*0735 B7 – – – – – – – B7
B*0736 B7 – – – B7 [100]b 1 – – B7 Bw4 positive
B*0737 B7 – – – – – – – B7
B*0738 Undefined – – – – – – – Not assignede
B*0739 B7 – – – – – – – B7
B*0740 B7 B7 – – – – – – B7
B*0741 B7 – – – – – – – B7
B*0742 B7 – – – – – – – B7
B*0743 B7 – – – – – – – B7
B*0744 B7 – – – – – – – B7
B*0745 B7 – – – – – – – B7
B*0746 B7 B7 – – – – – – B7
B*0747 B7 – – – – – – – B7
B*0748 B7 – – – – – – – B7
B*0749N Not expressed Null – – – – – – NT
B*0750 Undefined – – – – – – – NT NN: B7
B*0751 B7 – – – – – – – B7
B*0752 B7 – – – – – – – B7
B*0753 B7 – – – – – – – B7
B*0754 B7 – – – – – – – B7
B*0755 B7 – – – – – – – B7
B*0756 B7 – – – – – – – B7
B*0757 B7 B7 – – – – – – B7
B*0758 B7 B7 – – – – – – B7
B*0801 B8 B8 B8 [100]a 9 B8 [99] 6518 B8 61 Training – B8
bd
B*0802 B8 B8 – – 2 B‘0802’ 1 Not assignede B8 Bw4; ihw13: B8
Bw4 with extra
reactions; NN: B8
B*0803 B8 B8 – – B8 [100]b 1 – – Not assignede B8 Bw4
B*0804 B8/blank – B8 [51–71], B59 [6–7] 3 B8 [80], blank [20]b 5 B8 1 B8 Blank Bw6; ihw13:
short B8
bd
B*0805 B8 – – – 1 – – B8
115
Table 2 Continued
116

B*0806 B8 B8 – – B8 [100]b 1 – – B8
B*0807 B8 B8 – – B8 [100]b 1 – – B8
B*0809 B8 B8 – – B8 [100]b 11 B8 2 B8
B*0810 B8 B8 – – – – – – B8 Short B8
B*0811 B8 – – – B8 [100]b 3 – – B8
bd
B*0812 B8 – – – 1 – – B8
B*0813 B8 – – – B8 [100]b 1 – – B8
B*0814 B8 – – – – – – – B8
B*0815 B8 B8 – – – – B8 1 B8
B*0816 B8 B8 – – – – – – B8
B*0817 Undefined – – – – – – – Not assignede B blank; NN: B8
B*0818 B8 B8 – – – – – – B8
B*0820 B8 – – – – – – – B8
B*0821 B8 – – – – – – – B8
B*0822 B8 – – – – – – – B8
B*0823 B8 – – – – – – – B8
B*0824 B8 – – – – – – – B8
B*0825 B8 – – – – – – – B8
B*0826 B8 – – – – – – – B8
B*0827 B8 – – – – – – – B8
B*0828 B8 – – – – – – – B8
B*0829 B8 B8 – – – – – – B8
B*0831 B8 – – – – – – – B8
B*0832 B8 – – – – – – – B8
B*0833 B8 – – – – – – – B8
B*1303 B49/B15 – – – B13 [100]b 1 – – B13 B15x21–Bw4; B21
variant with some
B15 sera reactive
B*1304 B49/B15 B15/B21 B21 [22–38], B49 [15], 2 – – B‘1304’ 1 B13 B15x21–Bw4, similar
B15 [7–17], B15x21 to B*1303; ihw13:
[0–15], B50 [5–11], new pattern, also
B63 [0–8], B77 [4–7] B49, B63 and B77
reactivity
Table 2 Continued

B*1306 B13 – – – – – – – B13

B*1308 B13 – – – – – – – B13
B*1309 Undefined – – – – – – – Not assignede Bw6pos; NN: B13
B*1310 B13 – – – B13 [100]b 2 – – Not assignede NN: B13 B15
B*1311 B13 – – – B13 [100]b 1 – – B13
B*1312 B13 – – – – – – – B13
B*1313 B13 B13 – – – – B13
B*1314 B13 – – – – – – – B13
B*1315 B13 – – – – – – – B13
B*1316 B13 – – – – – – – B13
B*1317 B13 – – – – – – – B13
B*1318 B13 – – – – – – – B13
B*1319 B13 – – – – – – – B13
B*1320 B13 – – – – – – – B13
B*1401 B64 B64(14) B14 [49–58], B64 8 B14 [72], B64 [10], 1003 B64 11 Training – B14
[32–43], B65 B65 [10]
[2–10]a
B*1402 B65 B65(14) B65 [50–54], B14 9 B14 [71], B65 [25], 2244 B65 22 Training – B14
[45–47], B64 [1–3]a B64 [2]
B*1403 B14 B14c – – B14 [50], B65 [35] 40 – – B14
B*1404 B14 – – – B14 [67], B64 [33]b 3 – – B14
B*1405 B14 – – – B14 [40], blank [60]b 5 B65 1 B14
B*1406 B14 B14 – – B14 [100]b 8 – – B14 B65
B*1407N Not expressed Null – – – – NT
B*1501 B62 B62(15) B62 [93–98]a 30 B62 [96], B15 [2] 1906 B62 64 Training – B15 B62
B*1502 B75 B75(15) B75 [79–86], B15 16 B75 [62], B62 [22], 1035 B75 18 Training – B15 B75
[8–11], B62 [5–12] B15 [7]
[31–45]a B35 [2], B62 [1],
blank [11]
B*1504 B62 B62(15) B62 [90], B15 [5], 1 B62 [69], B15 [10] 29 B62 1 B62
B75 [4]a
B*1505 B62 B62(15) B62 [88] 1 B62 [64], B15 [18] 22 B62 3 B62
B*1506 B62 B62(15) – – B62 [81]b 13 – – B62
B*1507 B62 B62(15) B62 [93] 2 B62 [79] 101 B62 2 Training – B15 B62
117
Table 2 Continued
118

B*1508 B75/B62 B75(15) B75 [30–48], B15 2 B62 [20], B15 [18], 45 B75 3 B15
[19–35], B62 B75 [18]
[6–19], B‘1508’
[11–14]
B*1509 B70 B70 – – B70 [53], blank [33] 65 B71 2 Training – B70 B71
B*1510 B71 B71(70) B70 [41–49], B71 15 B70 [49], B35 [4], B72 1204 B71 7 Training – B70 B71
[41–47]a [2], B71 [2], B75 [1],
B15 [1], blank [13]
B*1511 B75 B75(15) B75 [31–51], B15 3 B62 [27], B75 [21], 68 B75 4 B15
[21–38], B46 B46 [15], B15 [15]
[6–12], B‘1511’
[0–19]
[3–6] B75 [6], B15 [29]b
[0–16] B15 [15], B75 [12],
blank [13], B62 [8],
B53 [6]
B*1514 B76 B76(15) B76 [23], B45 [20], 1 B45 [80], B44 [20]b 5 B76 1 B62
B15 [20], B70 [6],
B63 [5]
B*1515 B75/62 B62(15) B75 [43–57], B62 10 B62 [49], B75 [28], 138 B75 1 B15 ihw13: short B75
[31–42], B15 B15 [13]
[8–15]a
B*1516 B63 B63(15) B63 [96–97]a 8 B63 [80], B57 [3], 816 B63 3 Training – B15 B63
B15 [3]
B*1517 B63 B63(15) B63 [92–96] 5 B63 [88], B15 [3], 797 B63 11 Training – B15 B63
B57 [1]
B*1518 B71 B71(70) B70 [52–64], B71 11 B70 [51], blank [34], 552 B71 8 Training – B70 B71
[28–34]a B71 [3]
B*1519 B76 B76(15) B76 [29], B15 [19], 1 B70 [50], B76 [50]b 2 – – B76
B45 [11], B62 [8],
B75 [7]
B*1520 B62 B62(15) B62 [73], B15 [18], 1 B62 [100]b 10 B62 1 B62 ihw13: short B62
B75 [5]
[6–9], B62 [3–10] B15 [7]
Table 2 Continued

e
B*1523 B70/B5/blank – B‘1523’ [17], B5 2 Blank [50], B70 [17], 12 B‘1523’ 2 Not assigned B5x70–Bw4, B5/53/
[14–15], B77 B51 [17], B53 [8]b 77 variant; NM5;
[7–11], B70 [7–9], ihw13: new
B15 [5–8] pattern, short B71-
Bw4; NN: B70 B71
B*1524 B62 B62(15) B62 [45–48], B‘1524’ 4 B62 [44], blank [22] 54 B62 8 B15 B62 Bw4
[23–24], B15
[21–22], B77 [4–6],
B63 [2–3]
B*1525 B62 B62(15) B62 [86–94], B75 10 B62 [74], B75 [8], 116 B62 1 Training – B15 B62 ihw13: short B62,
[2–10]a B15 [7] short B75
B*1527 B62 B62(15) B62 [97]a 1 B62 [76], B15 [7] 76 B62 2 Training – B15 B62 ihw13: short B62,
short B75
B*1528 B62 B62(15)c – – B62 [80], B15 [20]b 5 – – B62
B*1529 B70 B15 B70 [54–58], B15 2 Blank [71], B70 [19] 21 B71 2 B71
[11–12], B71 [7–10]
B*1530 B62 B62(15)c B62 [63–86], B75 3 B62 [64], B15 [17] 98 B62 3 Training – B15 B62 ihw13: short B62,
[4–13], B15 [12–19] short B75
B*1531 B75 B75(15) – – B75 [38], B62 [38]b 13 B75 1 B75 ihw13: short B75
B*1532 B62 B62(15) – – B62 [100]b 5 – – B62
B*1533 B62 B15 – – – – – – B62 B62
B*1534 B62 B62(15)c – – B62 [100]b 8 – – B62 Normal B62
B*1535 B62 B62(15)c B62 [86–93], B75 14 B62 [79] 34 B62 5 Training – B15 B62
[5–7]a
B*1536 Undefined – – – B13 [100]b 3 – – B15 Bw4 positive, NN:
B77
B*1537 B70 B70c B70 [46], B71 [11], 2 Blank [54], B70 [30] 24 – – B71
B78 [9]
B*1538 B62 – – – B62 [100]b 3 – – B62 B62 variant, also
reactive with B52
sera
B*1539 B62 B62(15)c B62 [92–98] 2 B62 [84], B15 [13]b 38 B62 3 B62
B*1540 B62/blank – – – Blank [61], B70 [10], 26 – – B62 Short B62
B62 [8]
B*1542 B15 – – – – – – – B62 Short B15; reactive
with some B22 sera
119
Table 2 Continued
120

B*1543 B15 – – – – – – – B15f Bw4 positive, NN:

B62
B*1544 B75 – – – – – – – B75
B*1545 B62 B62(15) – – B62 [92]b 13 – – B62
B*1546 Undefined B72(70) – – B50 [50], B72 [25]b 4 – – Not assignede NN: B15 B62
B*1547 B70/blank – – – Blank [57], B35 [14]b 14 – – B72 B48, all B15 sera
negative
B*1548 B62 B62(15) – – B62 [100]b 3 – – B62
B*1549 B72 – – – – – – – B72
B*1550 B62 – – – – – – – B62
B*1551 B70 B70 – – B35 [100]b 1 – – B71
B*1552 Undefined B15 – – Blank [67]b 3 – – B71 B15
B*1554 B72 – – – B70 [50], B72 [50]b 2 – – B72
B*1555 B15 B15 – – – – – – B15f B15 Bw6; NN: B75
B*1556 B62 – – – – – – – B62
B*1557 B62 – – – – – – – B62
B*1558 B62 B62(15) – – B62 [100]b 3 – – B62 B15 or B62
B*1560 B62 – – – – – – – B62
B*1561 B72 – – – – – – – B72
B*1562 Undefined – – – B62 [67]b 3 – – Not assignede NN: B70 B72
B*1563 B62 – – – B62 [100]b 2 – – B62
B*1564 B71 – – – – – – – B71
B*1565 B62 – – – B62 [100]b 2 – – B62
B*1566 B62 – – – B62 [100]b 1 – – B62
B*1567 B63 – – – – – – – B63 Bw4 positive
B*1568 Undefined B35 – – – – – – Not assignede NN: B70 B72
B*1569 B72 – – – – – – – B72
B*1570 B62 B62(15) – – – – B62 1 B62 ihw13: short B62,
short B75
B*1571 B62 B62(15) – – B62 [83], B75 [17]b 6 – – B62
B*1572 B71 – – – – – – – B71
B*1573 B62 B62(15) – – B62 [100]b 1 – – B62
B*1574 B72 – – – – – – – B72
B*1575 B62 – – – B62 [100]b 1 – – B62
B*1577 B62 – – – – – – – B62
B*1578 B62 B15 – – – – – – B62
Table 2 Continued


B*1580 B70 B70 – – – – – – B71 B70
B*1581 B62 – – – – – – – B62
B*1582 B62 B62(15) – – – – – – B62 B62 1 A30/31
B*1583 B62 – – – – – – – B62 NN: B15
B*1584 B62 B62(15) – – – – – – B62
B*1585 B62 – – – – – – – B62
B*1586 Undefined – – – – – – – Not assignede NN: B15, B62
B*1587 B15 – – – – – – – B15
B*1588 B75 – – – – – – – B75
B*1589 B77 – – – – – – – B77
B*1590 B71 – – – – – – – B71
B*1591 Undefined – – – – – – – Not assignede NN: B70, B72, B12
B*1592 B62 – – – – – – – B62
B*1593 B71 B71(70) – – – – – – B71
B*1595 B63 – – – – – – – B63
B*1596 B62 B62(15) – – – – – – B62
B*1597 B62 – – – – – – – B62
B*1598 B72 – – – – – – – B72
B*1599 B71 – – – – – – – B71
B*9502 B62 B62(15) – – – – – – B62
B*9503 B70 B70 – – – – – – B72
B*9504 B62 – – – – – – – B62
B*9505 B62 – – – – – – – B62
B*9507 B62 B62(15) – – – – – – B62
B*9508 B71 B71(70) – – – – – – B71
B*9509 B62 – – – – – – – B62
B*9510 B62 – – – – – – – B62
B*9512 B75 B15 – – – – – – B75
B*9513 B62 – – – – – – – B62
B*9514 B70 B70 – – – – – – B71
B*9515 B70 – – – – – – – B70
B*9516 B62 – – – – – – – B62
B*9517 B62 – – – – – – – B62
121
Table 2 Continued
122

B*9518 B62 – – – – – – – B62

B*9519 B71 – – – – – – – B71
B*9520 B62 – – – – – – – B62
B*9521 B75 – – – – – – – B75
B*9522 B62 – – – – – – – B62

B*9523 B72 – – – – – – – B72
B*9524 B71 – – – – – – – B71
B*9525 B62 – – – – – – – B62
B*9526 B62 – – – – – – – B62
B*9527 B72 – – – – – – – B72
B*9528 B62 – – – – – – – B62
B*9529 B62 – – – – – – – B62
B*9530 B62 – – – – – – – B62
B*9532 B72 – – – – – – – B72
B*1802 B18 B18 – – B18 [90] 31 B18 3 Training – B18
B*1803 B18 B18 – – B18 [83], blank [17] 29 B18 1 B18
B*1804 B18 B18c – – B18 [84], blank [11]b 19 B18 1 Not assignede NN: B18
B*1805 B18 B18 – – B18 [83]b 6 B18 1 B18 ihw13: short B18,
blank
B*1806 B18 B18 – – – – – – B18 B18 variant, negative
with Bw4 and Bw6
sera
B*1807 B18/blank – – – Blank [100]b 1 B18 1 B18 ihw13: short B18,
blank, B18 spec
sera negative
B*1808 B18 – – – B18 [100]b 1 – – B18
B*1809 B18 B18 – – – – – – Not assignede B18, Bw4; NN: B18,
B38
B*1810 B18 – – – – – – – B18
B*1811 B18 – – – – – – – B18
B*1812 B18 – – – B18 [50], blank [50]b 2 – – B18
B*1813 B18 – – – B18 [100]b 2 – – B18
B*1814 B18 – – – B18 [100]b 2 – – B18
B*1815 B18 – – – B18 [100]b 1 – – B18
B*1818 B18 – – – B18 [100]b 4 – – B18
B*1819 B18 – – – – – – – B18
Table 2 Continued

B*1820 B18 – – – – – – – B18

B*1822 B18 – – – – – – – B18
B*1824 B18 – – – – – – – B18
B*1825 B18 – – – – – – – B18
B*1826 B18 – – – – – – – B18
B*2701 B27 B27 – – B27 [100]b 12 – – B27
B*2702 B27 B27 B27 [97] 1 B27 [87] 417 B27 9 Training – B27 ihw13: short B27
B*2703 B27 B27 B27 [97] 1 B27 [88] 26 B27 5 Training – B27
B*2704 B27 B27 B27 [98]a 1 B27 [97] 31 B27 7 B27
B*2705 B27 B27 B27 [99–100] 6 B27 [99] 1194 B27 22 Training – B27
B*2706 B27 B27 B27 [97–99]a 10 B27 [97] 29 B27 6 B27 Previously also
named B*2722
B*2707 B27 B27 – – B27 [100]b 49 B27 5 B27
B*2708 B2708/B27/B7 B2708 B2708 [36–58], 3 B27 [31], B7 [34], 32 B2708 1 B27 B7 variant, most B27
B7 [19–41], B27 blank [16], B2708 sera negative;
[11–19] [9]b ihw13: also B73 B7
blank
B*2709 B27 B27 B27 [100] 1 B27 [100]b 15 – – B27
B*2710 B27 B27 – – B27 [100]b 5 – – B27
B*2711 B27 B27 – – B27 [100]b 2 – – Not assignede B27 variant, extra
reactivity with B40
sera; NN: B27
B*2712 Undefined B27 – – Blank [78], B60 [9], 23 Blank 1 Not assignede Blank Bw6; B27 sera
B27 [4], B61 [4]b negative, B7 1 27
(140) sera positive;
ihw13: blank, B61
B27–Bw6; NN: B27
B*2713 B27 B27 – – – – – – B27
B*2714 B27 B27c – – B27 [100]b 14 – – B27
B*2715 B27 – – – – – – – B27 Blank Bw4
B*2716 B27 – – – – – – – B27 Short B27, some B40
sera reactive
B*2717 B27 B27 – – – – – – B27 Normal B27
B*2718 Undefined – – – Blank [100]b 2 – – Not assignede Bw6 positive
B*2719 B27 B27 – – – – – – B27 Normal B27
B*2720 B27 B27 – – – – – – B27
123
Table 2 Continued
124

B*2721 B27 – – – – – – – B27

B*2723 Undefined – – – – – – – Not assignede Blank Bw6, Bw4
negative/weak,
only reactive with
few B44 1 27 sera

B*2724 B27 – – – – – – – B27
B*2725 B27 – – – – – – – B27
B*2726 B27 – – – – – – – B27
B*2727 B27 – – – – – – – B27
B*2728 B27 – – – – – – – B27
B*2729 B27 B27 – – – – – – Not assignede NN: B27
B*2730 B27 B27 – – – – – – B27
B*2731 B27 – – – – – – – B27
B*2732 B27 – – – – – – – B27
B*2733 Undefined – – – – – – – Not assignede NN: B27, B40, B61
B*2734 B27 – – – – – – – B27 NN: B27
B*2735 B27 – – – – – – – B27
B*2736 B27 – – – – – – – B27
B*2737 B27 – – – – – – – B27
B*2738 B27 B27 – – – – – – B27
B*3504 B35 B35 – – B35 [100] 26 – – B35
B*3506 B35 B35 – – B35 [100]b 13 – – B35
B*3507 B35 B35 – – – – – – B35
B*3509 B35 B35 – – B35 [100]b 3 – – B35
B*3510 B35 B35c – – B35 [77], B70 [15]b 13 B35 1 B35 ihw13: short B35
B*3511 B35 B35 – – B35 [88]b 16 – – B35
B*3512 B35 B35 B35 [98–100]a 12 B35 [78] 422 B35 2 B35
b
B*3513 B35 B35 – – – – – B35
B*3514 B35 B35 B35 [98]a 1 B35 [79] 29 – – B35
B*3515 B35 B35 – – Blank [50], B35 [33]b 6 – – B35 Short B35, B75 CREG
sera reactive
B*3516 B35 B35c B35 [63], B70 [20] 2 B35 [33], blank [34] 41 B35 1 B35 ihw13: short B35
Table 2 Continued

b
B*3518 B35 B35 – – B35 [100] 1 – – B35
B*3519 B35/blank B35 – – B35 [40], B70 [20], 5 Blank 2 B35 ihw13: new pattern,
B77 [20]b blank, very short
B35
B*3520 B35 B35 – – B35 [42], blank [13] 23 B35 5 B35
B*3521 B35/B78 – – – B35 [42], B78 [33], 12 B78 1 B35 ihw13: B35/78 variant
blank [25]b
B*3522 B35 – – – B35 [100]b 2 – – B35
B*3523 B35 B35c B35 [84–88] 4 B35 [92]b 13 B35 1 B35
B*3524 B35 – – – B35 [75], B78 [25]b 8 – – B35
B*3525 B35 B35c – – B35 [33], blank [67]b 3 B35 1 B35 ihw13: short B35
B*3526 B35 – – – – – – – B35
B*3527 B35 B35 – – B35 [100]b 2 – – B35
B*3528 B35 – – – B35 [50], blank [43]b 14 – – B35
B*3529 B35 B35 – – B35 [100]b 2 – – B35
B*3530 B35 B35 – – B35 [100]b 7 – – B35 Normal B35
B*3531 B35 – – – Blank [67], B61 [17], 6 B35 1 B35 ihw13: short B35;
B48 [17]b reactive with few
B40 and B35 sera,
Korean
B*3532 B35 B35 – – B35 [100]b 2 – – B35
B*3533 B35 – – – – – – – B35
B*3534 B35 – – – B35 [100]b 1 – – B35
B*3535 B35 B35 – – – – – – B35
B*3536 B35 – – – B35 [100]b 1 – – B35
B*3537 B35 – – – B35 [100]b 1 – – B35
bd
B*3538 B35 – – – 1 – – B35
B*3539 B35 – – – – – – – B35
B*3541 B35 B35 – – B35 [100]b 3 – – B35
B*3542 B35 B35 – – – – – – B35 Normal B35
B*3543 B35 B35 B35 [95–97]a 3 B35 [63], B70 [12] 379 B35 2 Not assignede Previously B*1522;
NN: B35
B*3544 Undefined B35 – – – – – – Not assignede Previously B*1559
B*3545 B35 – – – – – – – B35
B*3546 B35 B35 – – – – – – B35
B*3547 B35 – – – B35 [100]b 1 – – B35
B*3548 B35 – – – – – – – B35
125
Table 2 Continued
126

B*3549 B35 – – – B35 [100]b 1 – – B35

B*3550 B35 B35 – – – – – – B35
B*3551 B35 B35 – – – – – – B35
B*3552 B35 B35 – – – – – – B35

B*3554 B35 – – – – – – – B35
B*3555 B35 B35 – – – – – – B35
B*3556 B35 – – – – – – – B35
B*3557 B35 B35 – – – – – – B35
B*3558 B35 – – – – – – – B35
B*3559 B35 – – – – – – – B35
B*3561 B35 B35 – – – – – – B35
B*3562 B35 – – – – – – – B35
B*3564 B35 – – – – – – – B35
B*3565Q B35 – – – – – – – B35 Not expected to be
expressed
B*3566 B35 – – – Blank [100]b 1 – – B35
B*3568 B35 – – – – – – – B35
B*3569 B35 – – – – – – – B35
B*3570 B35 B35 – – – – – – B35
B*3571 B35 – – – – – – – B35
B*3572 B35 – – – – – – – B35
B*3573 B35 – – – – – – – B35
B*3574 B35 – – – – – – – B35
B*3575 B35 – – – – – – – B35
B*3576 B35/22 B35/22 – – – – – – B22f NN: B56
B*3577 B35 – – – – – – – B35
B*3702 B37/B27 – – – B27 [33], blank [33], 6 – – Not assignede B37x27 or blank; few
B37 [17], B47 [17]b B37 and few B27
sera reactive; NN:
B37
Table 2 Continued

c b
B*3704 B37 B37 – – B37 [50], blank [50] 2 B37 1 B37 B37 variant, reactive
with few B37 and
B18 sera
B*3705 Blank – – – – – – – Not assignede Blank Bw6, B37, and
Bw4 sera negative,
Korean; NN: B37
B*3706 B37 – – – – – – – B37
B*3708 B37 B37 – – – – – – B37
B*3710 B37 B37 – – – – – – B37
B*3712 B37 – – – – – – – B37
B*3713 B37 – – – – – – – B37
B39 [1]
B*3802 B38 B38(16) B38 [91–99]a 15 B38 [87], B39 [2], 788 B38 15 Training – B16 B38 ihw13: different from
B16 [2] B*3801
B*3803 B38 B16 – – Blank [100]b 1 – – Not assignede B16 Bw4, B38, and
B39 sera negative;
NN: B16 B38
B*3804 B38 – – – – – – – B38
B*3805 B38 B38(16) – – – – – – B38 Normal B38
B*3806 B38 – – – – – – – B38
B*3807 B38 – – – – – – – B38
B*3808 B38 – – – – – – – B38
B*3809 B38 B16c – – – – – – B38 B16–Bw4, on cell
VOA Ter 299
B*3810 B38 – – – – – – – B38
B*3811 B38 – – – – – – – B38
B*3812 B38 B38(16) – – – – – – B38
B*3813 B38 – – – – – – – B38
B*3814 B38 – – – – – – – B38
B*3815 B38 B38(16) – – – – – – B38
B*3816 B38 – – – – – – – B38
B*3901 B3901/B39 B3901 B39 [96–99]a 7 B39 [95] 476 B39 21 Training – B16 B39
B*39010102L Low B39 Low B39 – – – – Identical to B*3901
127
Table 2 Continued
128

B*3902 B3902/B39 B3902 B39 [97–99]a 7 B39 [87] 96 B39 5 Not assignede ihw13: short B39; NN:
B16 B39
B*3903 B39 B39(16) – – B39 [89] 19 B39 1 B39
b
B*3904 B39 B39(16) – – – – – B39
B*3905 B39 B39c B39 [89–92], B16 17 B39 [82] 245 B39 4 B39 B39 variant, ST-16;
[4–7], B38 [1–5]a ihw13: B39 and
B38 sera positive
B*3906 B39 B39(16) B39 [96–99] 6 B39 [94] 508 B39 8 Training – B16 B39
B*3907 B16 – – – Blank [100]b 1 – – B16
B*3908 B39 B39(16) B39 [86–91], B16 4 B39 [48], blank [41] 57 B39 1 Not assignede ihw13: B39 and B38
[3–5] sera positive; NN:
B16
B*3909 B39 B39(16) B39 [96–99] 6 B39 [100]b 29 B39 2 B39
B*3910 B39 B39(16) B39 [98]a 4 B39 [82], blank [16] 127 B39 5 B39
B*3911 B39 B39(16)c – – B39 [79], blank [14]b 29 – – B39
B*3912 B39 B39(16) – – B39 [100]b 1 B39 1 B39
B*3913 B39 B39(16) – – B39 [40], blank [40]b 5 – – Not assignede NN: B16, B39
B*3914 B39 – – – B39 [100]b 4 – – B39
B*3915 B39 B39(16)c – – B39 [100]b 6 B39 1 B39
B*3916 B39 – – – – – – – B39
B*3917 B39 – – – B39 [100]b 1 – – Not assignede NN: B39, B16
B*3918 B39 – – – – – – – B39
B*3919 B39 B39(16)c – – Blank [100]b 1 B39 1 B39
B*3920 B39 – B39 [73], B16 [16]a 1 Blank [67], B38 [33]b 3 – – B16f NN: B38
bd
B*3922 B39 – – – 1 – – B39
B*3923 B39 B39(16) – – – – – – Not assignede NN: B16, B39
B*3924 B39 B39(16) – – B39 [97]b 30 B39 1 B39 Normal B39
B*3926 B39 – – – – – – – B39
B*3927 B39 B39(16) – – – – – – B39 Normal B39
B*3928 B39 – – – – – – – B39
B*3929 B39 – – – – – – – B39
B*3930 B39 – – – – – – – B39
B*3931 B39 – – – B39 [100]b 2 – – B39
B*3932 B16 – – – – – – – B16f NN: B39
B*3933 B39 – – – – – – – B39
B*3934 B39 B39(16) – – – – – – B39
B*3935 B39 – – – B39 [100]b 1 – – B39
Table 2 Continued

e
B*3936 Undefined – – – – – – – Not assigned NN: B39, B16, B14
B*3937 B39 – – – – – – – B39
B*3938Q B39 – – – – – – – B39 Not expected to be
expressed
B*3939 B39 – – – – – – – B39
B*3941 B39 B39(16) – – – – – – B39
B*3942 B39 – – – – – – – B39
B61 [2]
[3–19], B60 [2–21]a B40 [6]
B*4003 B61 B61(40)c – – B61 [62], B60 [23] 31 B61 1 B61
B*4004 B61 B61(40)c – – B61 [47], B60 [12] 57 B61 3 B61
B*4005 B4005/B50 B4005 B4005 [41–57], B50 3 B50 [34], B4005 [12], 293 – – B61 BN21, B21 variant
[28–36], B21 [5–9] blank [23], B61 [7],
B70 [4], B21 [4],
B60 [4]
B*4006 B61 B61(40) B61 [87–90], B40 [4], 6 B61 [75], B60 [5], 585 B61 17 Training – B40 B61
B60 [4–8]a B40 [5]
B*4007 B60 B60(40)c – – B60 [100]b 12 – – B60 B‘Fu’
B*4008 B61/blank – B61 [20–27], B40 3 Blank [71], B61 [12], 138 B61 2 B61 B40x48 variant, only
[20–30], B‘4008’ B40 [9] reactive with some
[9–10], B48 [2–14] B40 1 48 (17)
CREG sera
B*4009 B61 B61(40) – – B61 [60], B40 [20]b 5 B61 1 B61
B*4010 B60 B60(40) B60 [75–93], B40 10 B60 [43], B61 [25], 28 B60 2 B60 Short B60, B48 like
[14–15], B61 [3–8], B40 [14], blank
B48 [2–3]a [11]b
B*4011 B61 B61(40)c – – B61 [71], B60 [26]b 38 B61 2 B61
B*4012 B60/B48 – B48 [28–34], B70 [7– 3 B48 [37], B60 [26], 19 – – Not assignede B48x70, some
20], B40 [11], B72 blank [21], B40 reactivity with B40
[10], B‘4012’ [8], [16]b 1 48 and B15 1 70
B61 [5] CREG sera; NN:
B48
B*4013 Undefined – – – Blank [100]b 1 – – Not assignede B40 Bw4; NN: B61
B40
B*4014 B60 B60(40) – – B60 [100]b 3 – – B40f NN: B60
129
Table 2 Continued
130


B*4016 B61 B61(40) – – B61 [58], B60 [25], 12 – – Not assignede NN: B40, B41
B40 [17]b
B*4018 B61 – – – B61 [100]b 1 – – B61
B*4019 B61 – – – – – B‘4019’ 1 Not assignede B40Bw4, B*4002

with Bw4 epitope;
ihw13: new pattern
short B61 Bw4
positive; NN: B61,
B40
B*4020 B61 B61(40)c – – B61 [77], B60 [8], 13 B61 1 B61
B40 [8]b
B*4021 B40/B15 – – – – – – – Not assignede B40x15, reactive with
B40 1 48, B15 1 57
sera, not with B40
1 13 sera; NN: B15,
B48
B*4023 B40 – – – – – – – B40f NN: B60
B*4024 B61 – – – – – – – B61
B*4025 B40 – – – – – – – B60 Short B40, few B40
sera reactive
B*4026 B21 B21 – – – – – – B40f NN: B61
B*4027 B61 B61(40) – – B61 [68], B60 [26]b 19 – – B61 Normal B61
B*4029 B61 B61(40) – – – – B61 1 B61
B*4030 B60 – – – – – B60 1 B60 ihw13: B61 with few
B60 sera pos
bd
B*4031 B60 B60(40) – – 1 – – B60 Normal B60
B*4032 B40 – – – B60 [50], B61 [50]b 2 – – Not assignede NN: B40, B41
B*4033 B60 – – – – – – – B60
B*4034 B60 B60(40) – – – – – – B60
B*4035 B61 B61(40) – – – – – – B61 Short B40, B60 sera
negative
B*4036 B60 – – – – – – – B60
B*4037 B61 – – – B61 [100]b 1 – – B61
B*4038 B60 – – – – – – – B60
B*4039 B61/B41 B41 – – – – – – B61
Table 2 Continued

b
B*4040 B61 – – – B61 [100] 1 – – B61
B*4042 B60 – – – – – – – B60
B*4043 B60 – – – – – – – B60
B*4044 B61 – – – – – – – B61
B*4045 B60 – – – – – – – B60
B*4046 B60 – – – – – – – B60
B*4047 B40 B40 – – – – – – Not assignede B40 Bw4; short B60,
Bw4pos: NN: B40,
B60
B*4048 B60 B60(40) – – – – – – B60
B*4049 B60 – – – – – – – B60
B*4050 B61 B61(40) – – – – – – B61
B*4052 B60 B60(40) – – – – – – B60
B*4053 B61 B61(40) – – – – – – B61
B*4054 B60 B60(40) – – – – – – B60
B*4055 B60 – – – – – – – B60
B*4056 B61 B61(40) – – – – – – B61
B*4057 B61 – – – – – – – B61
B*4058 B40 – – – – – – – B40
B*4059 B40 – – – – – – – B40f NN: B60
B*4061 B60 – – – – – – – B60
B*4062 B60 – – – – – – – B60
B*4063 B60 – – – – – – – B60
B*4064 B61 B40 – – – – – – B61
B*4065 B60 – – – – – – – B60
B*4066 B60 – – – – – – – B60
B*4067 B60 – – – – – – – B60
B*4069 B60 – – – – – – – B60
B*4070 B61 B61(40) – – – – – – B61
B*4071 B61 – – – – – – – B61
B*4072 B60 – – – – – – – B60
B*4073 B60 – – – – – – – B60
B*4074 B60 – – – – – – – B60
B*4075 B61 – – – – – – – B61
B*4076 B60 – – – – – – – B60
131
Table 2 Continued
132

B*4077 B60 – – – – – – – B60

B*4103 B41 B41 – – B41 [92]b 13 – – B41
B*4104 B41 – – – – – – – B41

B*4105 B41 – – – – – – – B41 Short B41, Bw6 sera
negative
B*4106 B41 – – – – – – – B41
B*4107 B41 – – – – – – – B41
B*4108 B41 – – – – – – – B41
B*4201 B42 B42 B42 [89–97]a 12 B42 [93], B55 [1], B7 1015 B42 9 Training – B42
[1]
B*4202 B42 B42 B42 [87–96], B67 6 B42 [95] 80 B42 2 Training – B42
[0–12]
B*4204 B42 – – – – – – – B42
B*4205 B42 – – – Blank [100]b 1 – – B42
B*4206 B42 – – – – – – – B42
B*4208 B42 – – – – – – – B42
B*4209 B42 – – – – – – – B42
B*4402 B44 B44(12) B44 [99–100] – B44 [98] 6959 B44 55 Training – B12 B44
B*44020102S See comment Soluble – – – – – – Identical to B*4402 Secreted molecule
only (reference: 62)
B*4403 B44 B44(12) B44 [97–100]a 30 B44 [94] 2854 B44 65 Training – B12 B44
B*4404 B44 B44(12) – – B44 [65] 42 B44 7 B44 ihw13: short B44
B*4405 B44 B44(12) – – B44 [92] 130 B44 1 B44
B*4406 B44 B44(12) – – B44 [46], blank [31]b 13 B44 7 Not assignede Short B44 or blank;
ihw13: blank, short
B44; NN: B44, B12
B*4407 B44 B44(12) – – B44 [100]b 3 – – B44
B*4408 B44 B44(12) – – B44 [100]b 3 B44 3 B44 Short B44; also
reactive with B62 1
63 1 57 sera, in
Welsh, but very
rare; ihw13: new
pattern
Table 2 Continued

c b
B*4409 B45 B45(12) – – B45 [92] 12 B45 1 B12 B44Bw6, will be
typed as B45 or
B12; most B44- and
B45-specific sera
negative
B*4410 B44 B44(12)c – – B44 [70] 37 – – B12f NN: B44
B*4411 B44 – – – B44 [100]b 2 – – B44
B*4412 B44 B44(12) – – – – – – B44
B*4413 B44 B44(12) – – – – – – B44
B*4414 B44 B44(12) – – – – – – B44 Short B44
B*4415 B12 B12 – – – – – – B45 B45 Bw4, will be
typed as B44 or B12
B*4416 B47/B44 B47 B47 [52], B44 [12] 1 – – – – B44 B44x47, reactive with
most B47 and few
B44/12 sera
B*4417 B44 B44(12) – – B44 [100]b 1 – – B44
B*4418 B44 – – – B44 [100]b 1 – – B12f NN: B49
B*4420 B44 – – – B44 [100]b 1 – – B44
B*4421 B44 – – – B44 [100]b 1 B44 2 B44 ihw13: blank or very
short B44
B*4422 B44 – – – B44 [100]b 1 – – B44
B*4423N Not expressed Null – – – – Blank 1 NT
B*4424 B44 – – – – – – – B44
B*4425 B44 – – – B44 [100]b 1 – – B44
B*4426 B44 – – – – – – – B44
B*4427 B44 B44(12) – – B44 [100]b 30 – – B44 Short B44
B*4428 B44 – – – – – – – B44
B*4429 B44 B44(12)c – – B44 [100]b 2 – – B44 Normal B44
B*4430 B44 – – – – – – – B44
B*4431 B44 B44(12) – – – – – – Not assignede Almost normal B44;
NN: B60, B40, B12
B*4432 B44 B44(12) – – – – – – B44 Short B44
B*4433 B44 – – – – – – – B44
B*4434 B44 – – – – – – – B44
B*4435 B44 – – – – – – – B44 Normal B44
B*4436 B44 – – – – – – – B44
bd
B*4437 B44 – – – 2 – – B44
133
Table 2 Continued
134

B*4438 B44 – – – – – – – B44

B*4439 B44 – – – – – – – B44
B*4440 B44 B44(12) – – – – – – B44
B*4441 B44 – – – – – – – B44
B*4442 Undefined B21 – – – – – – B44

B*4443 B44 B44(12) – – – – – – B44
B*4444 B44 – – – – – – – B44
B*4445 B44 – – – – – – – B44
B*4446 B12 – – – – – – – B12
B*4447 B44 – – – – – – – B44
B*4448 B44 – – – – – – – B44
B*4449 B44 – – – – – – – B44
B*4450 B44 – – – – – – – B44
B*4451 B44 – – – – – – – B44
B*4453 B44 B44(12) – – – – – – B44
B*4454 B44 B44(12) – – – – – – B44
B44 [1], B50 [1]
B*4502 B45 – – – B45 [100]b 3 – – B45
B*4503 B45 – – – – – – – B45
B*4504 B21 – – – – – – – B21f NN: B50
B*4505 B45 – – – – – – – B45
B*4506 B45 – – – B45 [100]b 1 – – B12f NN: B45
B*4507 B45 – – – – – B45
B*4601 B46 B46 B46 [91–97]a 17 B46 [58], blank [27], 1487 B46 30 Training – B46
B62 [1], B35 [1]
B*4602 B46 B46 – – – – – – B46 B46 variant, negative
with B46 1 75 sera
B*4603 B46 B46 – – – – – – B46
B*4604 B46 B46 – – – – – – B46
B*4605 B46 B46 – – – – – – B46
B*4608 B46 – – – – – – – B46
B*4609 B46 – – – – – – – B46
B*4610 B46 – – – – – – – B46
B*4611 B22 – – – – – – – B22
Table 2 Continued

B*4701 B47 B47 B47 [90–96] 3 B47 [50], B27 [5], 311 B47 12 Training – B47
blank [32]
B*4702 B47 B47 – – B47 [40], blank [40], 5 B61 1 Not assignede B47 Bw6, B47 1 13 1
B60 [20]b 27 sera negative,
B40 1 13 1 47 sera
positive; NN: B47
B*4703 B47 B47 B47 [70–77], B60 2 Blank [33], B47 [17], 6 B47 1 B47 B47 Bw4, B47 1 13
[4–9], B61 [7–8], B13 [17], B40 [17], sera negative, B40
B40 [6–7] B61 [17]b 1 13 sera positive
B*4705 B17 – – – – – – – B47
B*4801 B48 B48 B48 [90–100]a 26 B48 [78], B60 [6], 610 B48 11 Training – B48
B61 [2], B40 [2]
B*4802 B48/B70 B48 – – Blank [44], B35 [16], 39 B71 2 Not assignede B71 like; ihw13:
B70 [13], B48 [3] pattern identical to
B*1510; NN: B35
B*4803 B48 B48c B48 [97]a 1 B48 [66], B60 [13] 32 B48 1 B48
B*4804 B48 B48 – – B48 [50], B40 [25]b 4 – – B48 Normal B48
B*4805 B48 B48 – – – – – – Not assignede NN: B48, B7
B*4807 B48 B48 – – B60 [42], B48 [33], 12 B48 2 B48
B61 [8]b
B*4809 B48 B48 – – – – – – B48
B*4810 B48 B48 – – – – – – B48
B*4811 B48 – – – – – – – B48
B*4812 B48 – – – – – – – B48
B*4814 B48 – – – – – – – B48
B*4815 B48 – – – – – – – B48
B*4816 B48 – – – – – – – B48
B*4817 Undefined B48/40 – – – – – – Not assignede NN: B48
B*4818 B48 – – – – – – – B48
B21 [1]
B*4902 B49 B49(21) – – B49 [100]b 6 – – B49 Normal B49
B*4903 B49 – – – – – B49 1 Not assignede Short B49; NN:
B49, B21
135
Table 2 Continued
136

B*4904 B49 – – – – – – – B49

B*4905 B49 B49(21) – – – – – – B49
B49 [2], B45 [1]
B*5002 B45 B45(12) B45 [87–91], B50 [7], 2 B45 [96] 79 B45 3 Training B12 B45
B44 [5]a
B*5004 B50 B50(21) – – B50 [67]b 3 – – B50
B52 [1]
B*5102 B5102/B51 B5102 B51 [38–57], B5102 11 B51 [73], B53 [11], 218 B5102 5 B51 ihw13: short B51 with
[21–33], B53 B52 [6], B5102 [3], some B35 1 53
[8–16], B5 [4–7], B5 [3] sera reactive
B52 [3–7]
B*5103 B5103/B51 B5103 – – B51 [100]b 3 – – B51
B*5104 B51 B51(5)c – – B51 [75], B52 [12], 8 B51 1 B51
B5 [12]b
B*5105 B51 B51(5) B51 [45], B53 [33], 1 B51 [48], B53 [24], 25 B51 3 B51 ihw13: B5102, short
B5 [3], B52 [3] B52 [16] B51 with some B35
1 53 sera reactive
B*5106 B51 B51(5) B51 [82–88], B53 5 B51 [64], B53 [12], 42 B51 5 B51 B5, most B51 sera
[1–4], B52 [0–4], B52 [7] negative; ihw13:
B5102 [0–3]a short B51, distinct
pattern
B*5107 B51 B51(5) – – B51 [78], B52 [9] 68 B51 3 Training – B5 B51 ihw13: short B51,
distinct pattern
B*5108 B51 B51(5) B51 [96–99]a 3 B51 [77], B53 [4] 154 B51 4 Training – B5 B51
B*5109 B51 B51(5) – – B51 [86] 43 – – Training – B5 B51
B*5110 B51 – – – Blank [100]b 2 B51 1 B51 ihw13: B5102, short
B51 with some B35
1 53 sera reactive
B*5112 B51/blank – – – – – – – B51 B ‘blank’, possibly not
expressed
B*5113 B51 – B51 [95–98]a 2 B51 [100]b 7 – – B51
B*5114 B51 B51(5)c – – B51 [88], B5 [12]b 17 B51 1 B51
B*5116 B51 B5 – – B51 [100]b 1 – – B51
B*5117 B51 B51(5) – – – – – – B51
Table 2 Continued

B*5118 B51 B51(5) – – – – – – B51

B*5119 B51 – – – – – – – B51
B*5120 B51 – – – – – – – B51
B*5121 B51 – – – B51 [100]b 1 – – B51
B*5122 B51 – – – B51 [100]b 2 – – B51
d
B*5123 B51 – – – 2 – – B51
B*5124 B51 B51(5) – – – – B51 1 B51
B*5126 B51 – – – – – – – B51
B*5128 B51 B51(5) – – – – B51 1 B51
B*5129 B51 B51(5) – – B51 [100]b 1 – – B51
B*5130 B51 – – – – – – – B51
d
B*5131 B51 B51(5) – – 1 – – B51
B*5132 B51 – – – – – – – B51
B*5133 B51 – – – – – – – B51
B*5134 B51 – – – – – – – B51
B*5135 B51 B51(5) – – – – – – B51
B*5136 B51 – – – – – – – B51
B*5137 B51 – – – – – – – B51
B*5138 B51 – – – – – – – B51
B*5139 B51 – – – – – – – B51
B*5140 B51 – – – – – – – B51
B*5142 Undefined B44(12) – – – – – – Not assignede NN: B44, B12, B53
B*5143 B51 B51(5) – – – – – – B51
B*5146 B51 B51(5) – – – – – – B51
B*5147 B51 – – – – – – – B51
B*5148 B51 – – – – – – – B51
B*5149 B51 – – – – – – – B51
B5 [2], B53 [1]
B*5202 B52 – – – B52 [100]b 2 – – B52 B15
B*5203 B52 – – – B52 [100]b 1 – – B52
B*5204 B52 B52(5) B52 [76], B5 [11] 1 – – – – B52 Normal B52
B*5205 B52 – – – – – – – B52
B*5206 B52 – – – – – – – B52
137
Table 2 Continued
138

B*5207 B52 B52(5) – – – – – – B52

B*5208 B52 B52(5) – – – – – – B52
B*5209 B52 – – – – – – – B52
B*5210 B52 – – – – – – – B52
B*5211 B52 – – – – – – – B52

B*5301 B53 B53 B53 [91–94]a 25 B53 [86], B35 [5], 3054 B53 20 Training – B53
B51 [1]
B*5302 B53 – – – B53 [83]b 6 – – B53
B*5303 B53/B35 – – – B35 [100]b 2 – – Not assignede NN: B35, B53
B*5304 B53 – – – B53 [100]b 2 – – B53 Long B53, some B5
sera reactive
B*5305 B53 – – – B53 [100]b 3 – – B53
B*5306 B53/B51 – – – – – B51 1 B53 B53x51, long B53,
extra reactivity with
some B51 sera
B*5307 B53 B53 – – – – – – Not assignede B53x37, reactive with
some B37 CREG
sera; NN: B51, B5
B*5308 B53 – – – – – – – B53
B*5309 B53 – – – – – – – B53
B*5310 B53 – – – B53 [100]b 1 – – B53
B*5311 B53 B53 – – – – – – B53
B*5312 B53 – – – – – – – B53
B*5313 B53 – – – – – – – B53
B22 [3], B56 [2],
blank [9]
B*5402 B54 B54(22) – – – – – – B54
B*5403 B22 – – – – – – – B54 B56
B*5404 B54 – – – – – – – B54
B*5407 B54 – – – – – – – B54
B*5410 B54 – – – – – – – B54
B*5411 B54 B54(22) – – – – – – B54
Table 2 Continued

B*5413 B54 – – – – – – – B54

B*5501 B55 B55(22) B55 [89–97] 4 B55 [92], B22 [5] 453 B55 21 Training – B22 B55
B22 [2]
B*5503 B55 B55(22)c – – B55 [100]b 1 – – B55 B55x67, some Bw6
sera negative
B*5504 B55 B55(22) – – B55 [80], B56 [7], 15 – – B22
B22 [7]b
B*5505 B55 B22 – – B22 [100]b 1 – – B55
B*5507 B54 B54(22) – – B55 [25], B54 [25], 4 – – B22f NN: B54
B56 [25], blank
[25]b
B*5508 B56 B56(22) – – – – B56 2 B56
B*5509 B22 B22 – – – – – – B55 Short B22, B7 CREG
sera positive,
negative with B55
and B56 sera
B*5510 B55 B55(22) – – B55 [100]b 1 – – B22
B*5511 B55 – – – – – – – B55
B*5512 B55 B22 – – – – – – B55
B*5513 B55 – – – B55 [100]b 1 – – B55 B55v
B*5515 B55 B55(22) – – – – – – B55
B*5516 B55 B22 – – – – – – B55
B*5517 B55 – – – – – – – B55
B*5519 B55 – – – – – – – B55
B*5520 B22 – – – – – – – B22f NN: B55
B*5521 B55 – – – – – – – B55
B*5522 B22 B55(22) – – – – – – B22f NN: B56
B*5523 B55 – – – B55 [100]b 1 – – B55
B*5524 B55 – – – – – – – B55
B*5525 B55 – – – – – – – B55
B*5526 B55 – – – – – – – B55
B*5527 B55 – – – – – – – B55
B*5601 B56 B56(22) B56 [94–96] 5 B56 [72], B22 [5], B55 671 B56 23 Training – B22 B56
[3], blank [8]
139
Table 2 Continued
140

B*5602 B56 B56(22) – – B56 [63], B55 [12], 8 B56 6 Training – B22 B56
blank [25]b
B*5603 B22/15 B22 – – B56 [65], B22 [6], 17 B56 1 Not assignede B22 variant, B55, B56
blank [12]b sera negative, B15
1 46 1 70 sera
reactive; in Asians
B*5604 B56 B56(22) B56 [88–93], B22 4 B56 [82], B54 [4], B22 28 B56 1 B56 Short B56s, some
[1–5]a [4], blank [11]b B56 and B22 sera
negative
B*5605 B56 B56(22) – – Blank [100]b 1 B56 4 B22 Short B56
B*5606 B78 B78 – – – – – – B22 B78 variant, some
B35 and B15 CREG
sera positive, all
B22 sera negative
B*5607 B56 B56(22) – – – – B56 1 Not assignede B56 Bw4, some B7
sera positive;
ihw13: B56 Bw4;
NN: B56, B22
B*5608 B56 – – – – – – – B56
B*5609 B56 – – – – – – – B56
B*5610 B55 B55(22) – – – – – – B55 Short B22, reactive
with B54 1 55 sera,
negative with B55
1 7 sera
B*5611 B56 B56(22) – – – – – – B56 Short B56
B*5612 B22 B55(22) – – – – – – B22
B*5613 B56 B56(22) – – – – – – B56
B*5614 B56 – – – – – – – B56
B*5615 B56 B56(22) – – – – – – B56
B*5616 B56 – – – – – – – B56
B*5617 B56 – – – Blank [100]b 1 – – B56
B*5620 B56 B56(22) – – – – – – B56
[1–7], B17 [1–6]a B58 [2]
B*5702 B57 B57(17) B57 [95–96]a 8 B57 [78], B17 [8] 65 B57 4 Training – B17 B57 ihw13: short B57
Table 2 Continued

a
B58 [6]
B*5704 B57 B57(17) – – B57 [67], B17 [7] 32 B57 1 B57 ihw13: short B57
B*5705 B57 – – – B57 [100]b 3 – – B57
B*5706 B57 – – – – – – – B57
B*5707 B57 – – – – – – – B57
B*5708 B57 B57(17) – – – – – – B57 Bw4 sera negative,
only strongly
reactive with B15 1
57 sera
B*5709 B57 – – – – – – – B57
B*5710 B57 – – – – – – – B57
B*5711 B57 – – – – – – – B57
B*5712 B57 – – – B57 [100]b 1 – – B57
B*5713 B57 – – – – – – – B57
B17 [4]
B17 [3]
B*5804 B58 – – – B58 [100]b 1 – – B58
B*5805 B58 – – – – – – – B58
B*5806 B58 – – – B58 [100]b 1 – – B58
B*5807 B58 – – – – – – – B58
B*5808 B17/B5 B17 – – – – – – B5 B17 and some B5
sera reactive; NN:
B17
B*5809 B17 – – – – – – – B58 B57
B*5811 B58 – – – – – – – B58
B*5812 B58 – – – – – – – B58
B*5813 B58 – – – – – – – B58
B*5814 B58 – – – – – – – B58
B*5815 B58 – – – – – – – B58
B*5901 B59 B59 B59 [92–95]a 9 B59 [45], blank [41] 123 B59 6 Training – B59
B*5902 B59 B59 – – – – – – B59
B*6701 B67 B67 B67 [86–90], B39 6 B39 [43], B67 [32], 81 B67 5 Training – B67 ihw13: pattern
[5–11]a B55 [8], blank [11] included in B22
B*6702 Undefined – – – B39 [100]b 1 – – Not assignede NN: B67
141
Table 2 Continued
142

B*7301 B73 B73 B73 [81–87] 4 Blank [69], B73 [22] 106 B73 3 Training – B73 ihw13: pattern similar
to B2708
B*7801 B78 B78 B78 [83–90], B35 5 B78 [41], B35 [15], 210 B78 1 Training – B78
[1–9], B51 [1–6] B51 [10], B70 [4],
blank [19]
B*7802 B78 B78 – – B78 [25], B35 [25], 4 – – B78
B51 [25]b
B*7803 B78 – – – – – – – B78
B*7804 B35 – – – B35 [100]b 5 – – Not assignede NN B35
B*7805 Undefined – – – – – – – Not assignede NN B52
B*8101 B81 B81 B81 [81–90], B7 12 B7 [76], B81 [8] 657 B81 7 Training – B81
[10–18], B48 [0–3]a
B*8102 B81 B81 B81 [89–90], B7 [10], 2 – – – – B81
B48 [0–3], B60
[2–3]a
B*8201 B82 B82 B‘8201’ [28], B22 [9] 1 Blank [68], B45 [4], 146 B‘82’ 4 B56 B22x45, reactive with
B70 [4], B‘82’ [3], some B45 and B22
B65 [3] sera; ihw13:
pattern almost
included in B55
B*8202 B82 – B82 [23], B81 [19], 1 B45 [33], blank [67]b 3 B‘82’ 1 B56
B‘8201’ [11], B56
[5], B22 [3], B42 [3]a
B*8301 Undefined – – – B45 [100]b 1 – – Not assignede
a
b
Updated NMDP data. In some cases the information reported in previous dictionaries has changed. Cells have been excluded from this study in some cases because their HLA typing has changed.
c
d
e
f
g
Ref 13–16, 29–57, 62.
Table 3 HLA-C alleles and their serologic designationsg
Expert WHO Cells Cells Cells Assigned

HLA allele assigned assigned Assigned type [%] tested Assigned type [%] tested Assignment tested type >0.55 Comments
a
Cw*0102 Cw1 Cw1 Cw1 [55–75] 76 Cw1 [92] 260 Cw1 104 Training – Cw1
Cw*0103 Cw1 Cw1 – – Cw1 [100]b 1 – – Cw1
Cw*0104 Cw1 – – – – – – – Cw1
Cw*0105 Cw1 – – – – – – – Cw1
Cw*0106 Cw1 – – – – – – – Cw1
Cw*0107 Cw1/blank – – – Cw1 [100]b 1 – – Cw1 Cw blank, the HLA
club cell
exchange: nine
laboratories
performing
serology
Cw*0108 Cw1 – – – – – – – Cw1
Cw*0109 Cw1 Cw1 – – – – – – Cw1 Short Cw1
Cw*0110 Cw1 – – – – – – – Cw1
Cw*0111 Cw1 – – – – – – – Cw1
Cw*0112 Cw1 – – – – – – – Cw1
Cw*0113 Cw1 – – – – – – – Cw1
Cw*0114 Cw1 – – – – – – – Cw1
Cw*0115 Cw1 – – – – – – – Cw1
Cw*0116 Cw1 – – – – – – – Cw1
Cw*0117 Cw1 – – – – – – – Cw1
Cw*0118 Cw1 – – – – – – – Cw1
Cw*0119 Cw1 – – – – – – – Cw1
Cw*0202 Cw2 Cw2 Cw2 [62–76]a 27 Cw2 [91] 382 Cw2 67 Training – Cw2
Cw*0203 Cw2 – – – Cw2 [100]b 1 – – Cw2
Cw*0204 Cw2 – – – – – – – Cw2
Cw*0205 Cw2 – – – – – – – Cw2
Cw*0206 Cw2 – – – – – – – Cw2
Cw*0207 Cw2 – – – – – – – Cw2
Cw*0208 Cw2 Cw2 – – – – – – Cw2
Cw*0209 Cw2 – – – – – – – Cw2
Cw*0210 Cw2 Cw2 – – Cw2 [75]b 4 Cw2
Cw*0211 Cw2 – – – – – – – Cw2
Cw*0212 Cw2 – – – – – – – Cw2
Cw*0213 Cw2 – – – – – – – Cw2
Cw*0214 Cw2 – – – – – – – Cw2
Cw*0215 Cw2 – – – – – – – Cw2
Cw*0216 Cw2 – – – – – – – Cw2
Cw*0217 Cw2 – – – – – – – Cw2
143
Table 3 Continued
144

Cw*0218 Cw2 – – – – – – – Cw2

Cw*0302 Cw10 Cw10(w3) Cw3 [45–67], Cw10 13 Cw3 [69], Cw10 [5] 41 Cw10 11 Cw10
[6–13]a
Cw*0303 Cw9 Cw9(w3) Cw3 [55–68], Cw9 38 Cw3 [80], Cw9 [6] 446 Cw9 75 Training – Cw3 Cw9
[8–15]a
Cw*0304 Cw10 Cw10(w3) Cw3 [52–69], Cw9 62 Cw3 [92], Cw10 [3], 603 Cw10 51 Training – Cw3 Cw10
[0–11], Cw10 Cw9 [1]
[3–12]a
Cw*0305 Cw3 – Cw3 [48], Cw10 [7]a 1 Cw3 [83], blank [17]b 12 – – Cw10
Cw*0306 Cw10 Cw10(w3)c Cw3 [52], Cw10 [6] 1 Cw3 [75], blank [25]b 16 Cw10 1 Cw10 ihw13: short pattern
Cw*0307 Cw3 Cw3 – – Cw3 [100]b 1 – – Cw10
Cw*0308 Cw10 – – – – – – – Cw10
Cw*0309 Cw10 Cw3c Cw3 [44–59], Cw10 3 Cw3 [100]b 1 – – Cw10
[3–6]
Cw*0310 Cw3 Cw3 – – Cw3 [100]b 1 – – Cw10
Cw*0311 Cw9 Cw3 – – – – – – Cw9
Cw*0312 Cw9 – – – – – – – Cw9
Cw*0313 Cw9 – – – – – – – Cw9
Cw*0314 Cw10 – – – – – – – Cw10
Cw*0315 Undefined – – – – – – – Not assignedd NN: Cw3, Cw10
Cw*0316 Blank – – – – – – – Cw3 Cw3, w9, w10 sera
negative; NN:
Cw10
Cw*0317 Cw10 – – – – Cw10
Cw*0318 Cw9 – – – Cw3 [100]b 1 Cw9
Cw*0319 Cw3 Cw3 – – – – – – Cw10
Cw*0320N Not expressed Null – – – – – – NT
Cw*0321 Cw9 – – – – – – – Cw9
Cw*0322Q Undefined – – – – – – – Cw9 Not expected to be
expressed
Cw*0323 Cw10 – – – – – – – Cw10
Cw*0324 Cw10 Cw3 – – – – – – Cw10
Cw*0325 Cw10 – – – – – – – Cw10
Cw*0326 Cw10 Cw10(w3) – – – – – – Cw10
Cw*0327 Cw10 – – – – – – – Cw10
Cw*0328 Cw10 Cw10(w3) – – – – – – Cw10
Cw*0329 Cw10 – – – – – – – Cw10
Cw*0330 Cw9 – – – – – – – Cw9
Table 3 Continued

Cw*0331 Cw9 – – – – – – – Cw9

Cw*0332 Cw10 – – – – – – – Cw10
Cw*0333 Cw10 – – – – – – – Cw10
Cw*0334 Cw10 – – – – – – – Cw10
Cw*0335 Cw10 – – – – – – – Cw10
Cw*0336 Cw10 – – – – – – – Cw10
Cw*0337 Cw10 – – – – – – – Cw10
Cw*0338 Cw10 – – – – – – – Cw10
Cw*0339 Cw9 Cw3 – – – – – – Cw9
Cw*0340 Cw10 Cw3 – – – – – – Cw10
Cw*0341 Cw10 – – – – – – – Cw10
Cw*0401 Cw4 Cw4 Cw4 [54–76]a 107 Cw4 [98] 736 Cw4 114 Training – Cw4
Cw*0403 Cw4/Cw6 – Cw4 [16–33], Cw6 35 Blank [100]b 7 Cw4 11 Not assignedd NN: Cw4; Cw4/6
[7–26], C‘403’ variant; ihw13: Cw6
[3–8]a or blank, only Cw4
1 6 sera reactive
Cw*0404 Cw4 – – – Cw4 [75], blank [25]b 4 Blank 1 Cw4
Cw*0405 Cw4 – – – Cw4 [100]b 2 – – Cw4
Cw*0406 Cw4/Cw6 – Cw6 [27–33], Cw4 4 – – – – Not assignedd NN: Cw4
[20–25], C‘403’
[2–3]a
Cw*0407 Cw4 Cw4c – – Cw4 [100]b 1 Cw4 1 Cw4
be
Cw*0408 Cw4 – – – 1 – – Cw4
Cw*0409N Not expressed Null – 1 Blank [100]b 2 – – NT
Cw*0410 Cw4 Cw4 – – Cw4 [100]b 1 – – Cw4 Normal Cw4
Cw*0411 Undefined – – – – – – – Not assignedd NN: Cw4
Cw*0412 Cw4 – – – – – – – Cw4
Cw*0413 Cw4 – – – – – – – Cw4
Cw*0414 Cw4 – – – – – – – Cw4
Cw*0415 Cw4 – – – – – – – Cw4
Cw*0416 Cw4 – – – – – – – Cw4
Cw*0417 Cw4 – – – – – – – Cw4
Cw*0418 Cw4 – – – – – – – Cw4
Cw*0419 Cw4 – – – – – – – Cw4
Cw*0420 Cw4 Cw4 – – – – – – Cw4
Cw*0421 Cw4 – – – – – – – Cw4
Cw*0423 Cw4 – – – – – – – Cw4
Cw*0424 Cw4 – – – – – – – Cw4
Cw*0425 Cw4 – – – – – – – Cw4
145
Table 3 Continued
146

Cw*0426 Cw4 – – – – – – – Cw4

Cw*0427 Cw4 – – – – – – – Cw4
Cw*0501 Cw5 Cw5 Cw5 [50–63]a 13 Cw5 [83], blank [15] 579 Cw5 69 Training – Cw5
Cw*0502 Cw5 Cw5 – – Cw5 [100]b 2 – – Cw5
Cw*0503 Cw5 – – – – – – – Cw5

Cw*0504 Cw5 – – – – – – – Cw5
Cw*0505 Cw5 – – – Blank [100]b 1 – – Cw5
Cw*0506 Cw5 – – – – – – – Cw5
Cw*0508 Cw5 – – – – – – – Cw5
Cw*0509 Cw5 – – – Cw5 [100]b 1 – – Cw5
Cw*0510 Cw5 – – – – – – – Cw5
Cw*0511 Cw5 – – – – – – – Cw5
Cw*0512 Cw5 – – – – – – – Cw5
Cw*0513 Cw5 – – – – – – – Cw5
Cw*0514 Cw5 – – – – – – – Cw5
Cw*0515 Cw5 – – – – – – – Cw5
Cw*0516 Cw5 – – – – – – – Cw5
Cw*0517 Cw5 – – – – – – – Cw5
Cw*0602 Cw6 Cw6 Cw6 [51–71]a 44 Cw6 [74], Cw4 [1], 665 Cw6 104 Training – Cw6
blank [12]
Cw*0603 Cw6 – – – Cw6 [100]b 1 – – Cw6
Cw*0604 Cw6 – – – Cw6 [100]b 2 – – Cw6
Cw*0605 Cw6 Cw6 – – – – – – Cw6
Cw*0606 Cw6 – – – – – – – Cw6
Cw*0607 Cw6 – – – Blank [100]b 1 – – Cw6
Cw*0608 Cw6 – – – – – – – Cw6
Cw*0609 Cw6 – – – – – – – Cw6
Cw*0610 Cw6 – – – – – – – Cw6
Cw*0612 Cw6 – – – – – – – Cw6
Cw*0613 Cw6 – – – – – – – Cw6
Cw*0614 Cw6 – – – – – – – Cw6
Cw*0615 Cw6 – – – – – – – Cw6
b
Cw*0703 Cw7 – – – – – – Cw7
Table 3 Continued

Cw*0704 Cw7 Cw7 Cw7 [59–72] 14 Cw7 [64], blank [24] 54 Cw7 30 Cw7
Cw*0705 Cw7 Cw7c – – – – Cw7 2 Cw7
Cw*0706 Cw7 Cw7 Cw7 [62–76] 4 Cw7 [67], blank [33]b 3 – – Cw7
Cw*0707 Cw7 – – – Blank [100]b 1 – – Cw7
Cw*0708 Cw7 – – – Cw7 [100]b 1 – – Cw7
Cw*0709 Cw7 – – – Cw7 [100]b 1 – – Cw7
Cw*0710 Cw7 – – – Cw7 [100]b 1 – – Cw7
Cw*0711 Cw7 – – – – – – – Cw7
Cw*0712 Cw7 Cw7 – – – – – – Cw7
Cw*0713 Cw7 – – – – – – – Cw7
Cw*0714 Cw7 Cw7 – – – – – – Cw7
Cw*0715 Cw7 – – – – – – – Cw7
Cw*0716 Cw7 Cw7 – – Blank [100]b 1 – – Cw7
Cw*0717 Cw7 – Cw7 [61%] allele 1 – – – – Cw7
typed outside
primary cell range
Cw*0718 Cw7 – Cw7 [73]a 1 Cw7 [67], blank [33]b 3 – – Cw7
Cw*0719 Cw7 – – – – – – – Cw7
Cw*0720 Cw7 – – – – – – – Cw7
Cw*0721 Cw7 – – – – – – – Cw7
Cw*0722 Cw7 – – – – – – – Cw7
Cw*0723 Cw7 – – – – – – – Cw7
Cw*0724 Cw7 – – – – – – – Cw7
Cw*0725 Cw7 – – – – – – – Cw7
Cw*0726 Cw7 – – – – – – – Cw7
be
Cw*0727 Cw7 – – – 1 – – Cw7
Cw*0728 Cw7 – – – – – – – Cw7
Cw*0729 Cw7 – – – – – – – Cw7
Cw*0730 Cw7 Cw7 – – – – – – Cw7
Cw*0731 Cw7 – – – – – – – Cw7
Cw*0734 Cw7 – – – – – – – Cw7
Cw*0735 Cw7 – – – – – – – Cw7
Cw*0736 Cw7 Cw7 – – – – – – Cw7
Cw*0737 Cw7 Cw7 – – – – – – Cw7
Cw*0738 Cw7 Cw7 – – – – – – Cw7
Cw*0739 Cw7 – – – – – – – Cw7
147
Table 3 Continued
148

Cw*0740 Cw7 Cw7 – – – – – – Cw7

Cw*0741 Undefined – – – – – – – Cw8
Cw*0742 Cw7 – – – – – – – Cw7
Cw*0743 Cw7 – – – – – – – Cw7
Cw*0744 Cw7 Cw7 – – – – – – Cw7

Cw*0745 Cw7 Cw7 – – – – – – Cw7
Cw*0746 Cw7 – – – – – – – Cw7
Cw*0747 Cw7 – – – – – – – Cw7
Cw*0748 Cw7 – – – – – – – Cw7
Cw*0749 Cw7 Cw7 – – – – – – Cw7
Cw*0801 Cw8 Cw8 Cw8 [40–66]a 62 Cw8 [41], blank [34] 31 Cw8 40 Cw8 ihw13: pattern
different from
Cw*0802
Cw*0803 Cw8 Cw8 Cw8 [8–16]a 4 Blank [100]b 3 Blank 2 Cw8
Cw*0804 Cw8 Cw8c Cw8 [43–57]a 4 Cw8 [100]b 2 – – Cw8
Cw*0805 Cw8 – – – – – – – Cw8
Cw*0806 Cw8 – – – – – – – Cw8
Cw*0807 Cw8 – – – – – – – Cw8
Cw*0808 Cw8 – – – – – – – Cw8
Cw*0809 Cw8 – – – – – – – Not assignedd NN: Cw8, Cw7
Cw*0810 Undefined – – – – – – – Cw5
Cw*0812 Cw8 – – – – – – – Cw8
Cw*0813 Cw8 – – – – – – – Cw8
Cw*0814 Cw8 – – – – – – – Cw8
Cw*1202 Undefined – Blank, no Cw antigen 11a Blank [94] 85 Blank 27 Not assignedd ihw13: reactive with
reported by more broad Cw reagents
than 5% of the
laboratories
Cw*1203 Undefined – Blank 30a Blank [59], Cw7 [4] 238 Blank 75 Not assignedd ihw13: reactive with
broad Cw reagents
Cw*1204 Blank – Blank 4a Blank [100]b 3 – – Cw6
Cw*1206 Undefined – – – – – – – Not assignedd
Table 3 Continued

d
Cw*1210 Undefined – – – – – – – Not assigned
Cw*1214 Cw7 – – – – – – – Cw7
Cw*1402 Cw1/blank – Blank, no Cw antigen 19a Blank [93] 93 Cw1 36 Cw1 ihw13: short Cw1
reported by more
than 5% of the
laboratories
Cw*1403 Cw1/blank – Blank, no Cw antigen 5a Blank [100]b 11 Cw1 10 Not assignedd ihw13: short Cw1;
reported by more NN: Cw1
than 5% of the
laboratories
Cw*1404 Undefined – – – Blank [100]b 1 – – Not assignedd NN: Cw4, Cw1
Cw*1405 Cw1 – – – Blank [100]b 1 – – Cw1
Cw*1408 Cw1 – – – – – – – Cw1
Cw*1502 Undefined – Blank 31a Blank [90] 107 Blank 56 Not assignedd NN: Cw10, Cw3, Cw2
Cw*1503 Undefined – – – Blank [100]b 2 – – Not assignedd NN: Cw10, Cw3, Cw2
Cw*1504 Undefined – – – Blank [100]b 2 Blank 2 Not assignedd NN: Cw3, Cw2
Cw*1505 Undefined – Blanka 11a Blank [62], Cw7 [24], 29 Blank 5 Not assignedd NN: Cw10, Cw3,
Cw2 [10]b Cw2, Cw5
Cw*1507 Cw3 – – – – – – – Cw3f NN: Cw10
Cw*1508 Undefined – – – – – – – Not assignedd NN: Cw10, Cw3,
Cw2, Cw5
Cw*1509 Undefined – Blank 1 Blank [100]b 8 – – Not assignedd NN: Cw3, Cw2
Cw*1512 Undefined – – – – – – – Not assignedd NN: Cw3, Cw9, Cw2
149
Table 3 Continued
150


Cw*1521 Cw3 – – – – – – – Cw3f NN: Cw10
Cw*1601 Undefined – Cw7 [2–23]a 36 Blank [94] 276 Blank 57 Not assignedd
Cw*1602 Undefined – Blanka 3 Blank [97] 22 Blank 5 Not assignedd NN: Cw2, Cw6
Cw*1604 Undefined – – – Blank [100]b 10 Blank 2 Not assignedd NN: Cw1
Cw*1701 Cw7/blank – C‘17’ [27–43], Cw7 25 Blank [82], Cw7 [18]b 28 – – Not assignedd
[6–22]a
Cw*1703 Cw7/blank – C‘17’ [31–44], Cw7 3 Blank [100]b 8 – – Not assignedd
[10–20]a
Cw*1801 Cw6/blank – Cw6 [30–42]a 3 Cw4 [40], Cw6 [40], 5 – – Not assignedd NN: Cw6, Cw4
Cw7 [20]b
Cw*1802 Cw6/blank – Cw6 [32–49], Cw4 8 Cw6 [100]b 1 – – Not assignedd NN: Cw6, Cw4
[2–6]a
a
b
c
d
e
f
g
Ref 14, 58, 59.
Table 4 HLA-DRB1 alleles and their serologic designations
International Cell Exchange, UCLA NMDP NN
HLA allele Expert assigned WHO assigned Assigned type [%] Cells tested Assigned type [%] Cells tested Assigned type >0.55 Comments
DRB1*0101 DR1 DR1 DR1 [95–100]a 21 DR1 [97] 6317 Training – DR1
DRB1*0102 DR1 DR1 DR1 [86–95] 2 DR1 [95] 2035 Training – DR1
DRB1*0103 DR103/DR1 DR103 DR103 [75–80], 5 DR1 [56], DR103 1186 Training – DR1
DR1 [9–17]a [12], blank [18] DR103
DRB1*0104 DR1 DR1 – – – – DR1
DRB1*0105 DR1 – – – DR1 [100]b 2 DR1
DRB1*0106 DR1 – – – – – DR1
DRB1*0107 DR1 DR1 – – – – DR1
DRB1*0108 DR1 – – – – – DR1
DRB1*0109 DR1 DR1 – – – – DR1
DRB1*0110 DR1 – – – – – DR1
DRB1*0111 DR1 – – – – – DR1
DRB1*0112 DR1 – – – – – DR1
DRB1*0113 DR1 DR1 – – – – Not assignedc NN: DR1
DRB1*0114 DR1 – – – – – DR1
DRB1*0115 DR1 – – – – – DR1
DRB1*0116 DR1 – – – – – DR1
DRB1*0301 DR17 DR17(3) DR17 [33–70], 36 DR17 [64], DR3 9698 Training – DR3
DR3 [20–50], [33] DR17
DR18 [0–11]a
DR3 [27–35] [24], DR17 [3] DR18
DRB1*0303 DR18 DR18(3) – – DR18 [50], DR17 4 DR18
[50]b
DRB1*0304 DR17 DR17(3) DR17 [50], DR3 3 DR3 [57], DR17 7 DR17
[44–50]a [29]b
DRB1*0305 DR3 DR3 – – – – DR17
DRB1*0306 DR3 DR3 – – – – DR17
DRB1*0307 DR3 DR3d – – DR3 [100]b 1 DR17
DRB1*0308 DR3 – – – – – DR17
DRB1*0309 DR3 – – – – – DR17
DRB1*0310 DR3 DR17(3)d – – DR3 [100]b 1 DR17
DRB1*0311 DR3 DR17(3)d – – DR3 [100]b 1 DR17
DRB1*0312 DR3 DR3 – – – – DR17
DRB1*0313 DR3 – – – – – DR17
DRB1*0314 DR3 DR3 – – – – DR17
DRB1*0315 DR17 DR3 DR3 [38–40], 2 – – DR17
DR17 [20–25],
DR18 [0–10]a
DRB1*0316 DR3 – – – – – DR17
151
Table 4 Continued
152
DRB1*0317 DR3 – – – DR17 [100]b 1 DR3

DRB1*0318 DR3 – – – – – DR17
DRB1*0319 DR3 – – – – – DR17
DRB1*0320 DR3 – – – – – DR17
DRB1*0321 DR3 – – – – – DR17
DRB1*0322 DR3 – – – – – DR17

DRB1*0323 DR3 DR3 – – – – DR17
DRB1*0324 DR3 – – – – – DR17
DRB1*0325 DR3 – – – – – DR17
DRB1*0326 DR3 – – – – – DR17
DRB1*0327 DR3 – – – – – DR18
DRB1*0328 DR3 – – – – – DR17
DRB1*0329 DR3 – – – – – DR18
DRB1*0330 DR3 – – – – – DR17
DRB1*0331 DR3 – – – – – DR17
DRB1*0332 DR3 – – – – – DR17
DRB1*0333 DR3 – – – – – DR17
DRB1*0335 DR3 – – – – – DR18
DRB1*0401 DR4 DR4 DR4 [100]a 13 DR4 [98] 5118 Training – DR4
DRB1*0406 DR4 DR4 DR4 [89–100] 3 DR4 [89] 83 DR4
DRB1*0408 DR4 DR4 DR4 [100]a 1 DR4 [86] 258 DR4
DRB1*0409 DR4 DR4 – – DR4 [100]b 11 DR4
DRB1*0410 DR4 DR4 DR4 [100] 3 DR4 [84] 29 DR4
DRB1*0411 DR4 DR4 DR4 [94–100]a 3 DR4 [93] 76 DR4
DRB1*0412 DR4 – – – DR4 [100]b 1 DR4
DRB1*0413 DR4 DR4 – – DR4 [100]b 3 DR4
DRB1*0414 DR4 DR4 – – DR4 [100]b 1 DR4
DRB1*0415 DR4 DR4 DR4 [84–100], 4 DR4 [67]b 3 DR4 DR4x11
DR11 [20]a
DRB1*0416 DR4 DR4 DR4 [100] 2 DR4 [100]b 1 DR4
be
DRB1*0417 DR4 DR4 – – 1 DR4
DRB1*0418 DR4 – – – – – DR4
DRB1*0419 DR4 DR4 – – – – DR4
DRB1*0420 DR4 DR4 – – DR4 [100]b 1 DR4
Table 4 Continued
DRB1*0421 DR4 DR4 – – DR4 [100]b 1 DR4

DRB1*0422 DR4/DR3 DR4 – – – – DR4 DR4x3

DRB1*0423 DR4 DR4 – – – – DR4
DRB1*0424 DR4 DR4 – – – – DR4
DRB1*0425 DR4 DR4 – – – – DR4 Short DR4
DRB1*0426 DR4 DR4 DR4 [100] 3 DR4 [100]b 1 DR4
DRB1*0427 DR4 – – – – – DR4
DRB1*0428 DR4 DR4 – – – – DR4
DRB1*0429 DR4 DR4 – – – – DR4
DRB1*0430 DR4 – – – – – DR4
be
DRB1*0431 DR4 DR4 DR4 [100]a 2 1 DR4
DRB1*0432 DR4 DR4d DR4 [94–100]a 2 – – DR4
DRB1*0433 DR4 – – – DR4 [100]b 1 DR4
DRB1*0434 DR4 – – – – – DR4
DRB1*0435 DR4 – – – DR4 [100]b 1 DR4
DRB1*0436 DR4 – – – – – DR4
DRB1*0437 DR4 – – – – – DR4
DRB1*0438 DR4 – – – – – DR4
DRB1*0439 DR4 – – – – – DR4
DRB1*0440 DR4 – – – – – DR4
DRB1*0441 DR4 – – – – – DR4
DRB1*0442 DR4 DR4 – – – – DR4
DRB1*0443 DR4 – – – – – DR4
DRB1*0444 DR4 – – – – – DR4
DRB1*0445 DR4 – – – – – DR4
DRB1*0446 DR4 – – – – – DR4
DRB1*0447 DR4 – – – – – DR4
DRB1*0448 DR4 – – – – – DR4
DRB1*0449 DR4 – – – – – DR4
DRB1*0450 DR4 – – – – – DR4
DRB1*0451 DR4 – – – – – DR4
DRB1*0452 DR4 – – – – – DR4
DRB1*0453 DR4 – – – – – DR4
DRB1*0454 DR4 – – – – – DR4
DRB1*0455 DR4 – – – – – DR4
DRB1*0456 DR4 – – – – – DR4
DRB1*0457 DR4 – – – – – DR4
DRB1*0458 DR4 – – – – – DR4
DRB1*0459 DR4 – – – – – DR4
153
Table 4 Continued
154
DRB1*0460 DR4 – – – – – DR4

DRB1*0461 DR4 – – – – – DR4
DRB1*0462 DR4 – – – – – DR4
DRB1*0463 DR4 – – – – – DR4
DRB1*0464 DR4 DR4 – – – – DR4
DRB1*0703 DR7 DR7 – – – – DR7
DRB1*0704 DR7 DR7 DR7 [100] 2 – – DR7
DRB1*0705 DR7 – – – – – DR7
DRB1*0706 DR7 – – – – – DR7
DRB1*0707 DR7 – – – – – DR7
DRB1*0708 DR7 – – – – – DR7
DRB1*0709 DR7 DR7 – – – – DR7
DRB1*0710N Not expressed Null – – – – NT
DRB1*0711 DR7 – – – – – DR7
DRB1*0712 DR7 – – – – – DR7
DRB1*0713 DR7 – – – – – DR7
DRB1*0714 DR7 – – – – – DR7
DRB1*0802 DR8 DR8 DR8 [100]a 4 DR8 [96] 265 Training – DR8
DRB1*0803 DR8 DR8 DR8 [96–100] 12 DR8 [88], DR12 [3] 230 Training – DR8
DRB1*0805 DR8 DR8 – – DR8 [83]b 6 DR8
DRB1*0806 DR8 DR8 DR8 [96–100] 4 DR8 [95]b 21 DR8
DRB1*0807 DR8 DR8 DR8 [89] 1 DR8 [100]b 3 DR8
DRB1*0808 DR8 – – – – – DR8
DRB1*0809 DR8 DR8 – – DR8 [100]b 2 DR8 DR8 variant
DRB1*0810 DR8 DR8 DR8 [94–100]a 2 DR8 [67], DR12 9 DR8
[22]b
DRB1*0811 DR8 DR8 DR8 [89–94]a 2 DR8 [100]b 10 DR8
DRB1*0812 DR8 DR8 – – – – DR8
DRB1*0813 DR8 DR8 – – – – DR8
DRB1*0814 DR8 DR8 DR8 [74–78]a 2 – – DR8
DRB1*0815 DR8 – – – – – DR8
DRB1*0816 DR8 DR8 DR8 [85]a 1 – – DR8
DRB1*0817 DR8 DR8 – – – – DR8
DRB1*0818 DR8 DR8 – – DR8 [100]b 2 DR8
DRB1*0819 DR8 – – – – – DR8
DRB1*0820 undefined – – – – – Not assignedc NN: DR8
Table 4 Continued
DRB1*0821 DR8 – – – – – DR8

DRB1*0822 DR8 – – – – – DR8

DRB1*0823 DR8 – – – – – DR8
DRB1*0824 DR8 – – – – – DR8
DRB1*0825 DR8 – – – – – DR8
DRB1*0826 DR8 – – – – – DR8
DRB1*0827 DR8 – – – – – DR8
DRB1*0828 DR8 – – – – – DR8
DRB1*0829 DR8 – – – – – DR8
DRB1*0830 DR8 – – – – – DR8
DRB1*0831 DR8/DR11 DR11(5) – – – – Not assignedc NN: DR8, DR11
DRB1*0832 Undefined – – – – – Not assignedc NN: DR8, DR12
DRB1*0902 DR9 – – – – – DR9
DRB1*0903 DR9 – – – – – DR9
DRB1*0904 DR9 – – – – – DR9
DRB1*0905 DR9 DR9 – – – – DR9
DRB1*0906 DR9 – – – – – DR9
DRB1*1001 DR10 DR10 DR10 [87–100]a 14 DR10 [90], DR1 894 Training – DR10
[4], blank [2]
DRB1*1101 DR11 DR11(5) DR11 [88–100]a 15 DR11 [92], DR5 [5] 3474 Training – DR11
DRB1*1102 DR11 DR11(5) DR11 [89–100] 6 DR11 [89], DR5 [3] 430 Training – DR11
DRB1*1103 DR11 DR11(5) DR11 [84–100] 2 DR11 [89], DR5 [4] 397 Training – DR11
DRB1*1104 DR11 DR11(5) DR11 [87–100]a 13 DR11 [87], DR5 [4] 2119 Training – DR11
DRB1*1105 DR11 DR11(5) DR11 [90–100]a 2 DR11 [100]b 3 DR11
DRB1*1106 DR11 DR11(5) – – DR5 [79], DR11 14 DR11
[21]b
DRB1*1107 DR11 DR11(5)d – – DR11 [100]b 3 Not assignedc DR11x3; NN:
DR17, DR3, DR11
be
DRB1*1108 DR11 DR11(5) DR11 [91–100]a 3 1 DR11
DRB1*1109 DR11 DR11(5) DR11 [100] 1 DR11 [75], DR5 4 Training – DR11
[25]b
DRB1*1110 DR11 – – – DR11 [100]b 2 DR11
DRB1*1111 DR11 DR11(5) DR11 [87–90], 3 DR11 [90], DR5 10 DR11 DR11x13
DR13 [7–8], [10]b
DR5 [4–5]
DRB1*1112 DR11 – – – DR11 [100]b 5 DR11
DRB1*1113 DR11 DR11(5) DR11 [93]a 2 DR11 [86]b 7 DR11 DR11x14
DRB1*1114 DR11 DR11(5) DR11 [94–100]a 3 DR11 [100]b 2 DR11
155
Table 4 Continued
156
DRB1*1115 DR11 – – – DR11 [50], DR6 2 DR11

[50]b
DRB1*1116 DR11/DR13 DR11(5)/DR13 – – DR11 [100]b 1 DR11 DR11x13; DR11
(6)d (70), DR13 (30)
DRB1*1117 DR14 – – – – – DR14f NN: DR6
be
DRB1*1118 DR11 – – – 1 DR11
be
DRB1*1119 DR11 DR11(5) DR11 [100] 4 1 DR11
DRB1*1120 DR11 DR11(5) – – – – DR11 DR11x13
DRB1*1121 DR11 DR11(5) DR11 [88–97], 2 – – DR11
DR13 [12]a
DRB1*1122 Undefined – – – – – Not assignedc NN: DR11
DRB1*1123 DR11 DR11(5) – – – – DR11
DRB1*1124 DR11 – – – – – DR11
DRB1*1125 DR11 DR11(5) – – – – DR11
DRB1*1126 DR11 DR11(5) – – – – DR11
DRB1*1127 DR11 DR11(5) – – – – DR11
DRB1*1128 DR11 – – – – – DR11
DRB1*1129 DR11 DR11(5) DR11 [100] 2 – – DR11
DRB1*1130 DR11 – – – – – DR11
DRB1*1131 DR11 – – – – – DR11
DRB1*1132 DR11 – – – – – DR11
DRB1*1133 DR11 – – – – – DR11
DRB1*1134 DR11 – – – – – DR11
DRB1*1135 DR11 – – – – – DR11
DRB1*1136 DR11 – – – – – DR11
DRB1*1137 DR11 DR11(5) – – – – DR11
DRB1*1138 DR11 – – – – – DR11
DRB1*1139 DR11 – – – – – DR11
DRB1*1140 DR11 – – – – – DR11
DRB1*1141 DR11 – – – – – DR11
DRB1*1142 DR11 – – – – – DR11
DRB1*1143 DR11 – – – – – DR11
DRB1*1144 DR11 – – – – – DR11
DRB1*1145 DR11 – – – – – DR11
DRB1*1146 DR11 – – – – – DR11
DRB1*1147 DR11 – – – – – DR11
DRB1*1148 DR11 – – – – – DR11
DRB1*1149 DR11 – – – – – DR11
DRB1*1150 DR11 – – – – – DR11
Table 4 Continued
DRB1*1151 DR11 – – – – – DR11

DRB1*1152 DR11 DR11(5) – – – – DR14

DRB1*1153 DR11 – – – – – DR11
DRB1*1154 DR11 – – – – – DR11
DRB1*1155 DR11 – – – – – DR11
DRB1*1156 DR11 – – – – – DR11
DRB1*1157 DR11 – – – – – DR11
DRB1*1158 DR11 – – – – – DR11
DRB1*1159 DR11 – – – – – DR11
DRB1*1160 DR11 – – – – – DR11
DRB1*1161 DR11 – – – – – DR11
DRB1*1162 DR11 – – – – – DR11
DR13 [5–12] [4], DR8 [2],
DR11 [2]
DRB1*1202 DR12 DR12(5) DR12 [91–100] 17 DR12 [89] 162 Training – DR12
DRB1*1203 DR12 DR12(5) – – DR12 [100]b 4 DR12
DRB1*1204 DR12 – – – – – DR12 DR12x11
DRB1*1205 DR12 DR12(5) – – – – DR12
DRB1*1206 DR12 DR12(5) – – DR12 [100]b 3 DR12
DRB1*1207 DR12 – – – – – DR12
DRB1*1208 DR12 – – – – – DR12
DRB1*1209 DR12 – – – – – DR12
DRB1*1210 DR12 – – – – – DR12
DRB1*1211 DR12 – – – – – DR12
DRB1*1212 DR12 – – – – – DR12
DRB1*1213 DR12 – – – – – DR12
DRB1*1214 DR12 – – – – – DR12
DRB1*1215 DR12 – – – – – DR12
DRB1*1301 DR13 DR13(6) DR13 [90–100], 17 DR13 [81], DR6 3788 Training – DR6 DR13
DR6 [0–7]a [14], DR14 [1]
DR6 [7–11]a [17], DR14 [2]
DR6 [4–21], [10], DR12 [3],
DR‘1303’ DR11 [3], DR5
[0–11], DR14 [2], DR14 [2]
[0–17], DR3
[0–8]
157
Table 4 Continued
158
DRB1*1304 DR13 DR13(6) – – DR13 [87] 127 DR13

DRB1*1305 DR13 DR13(6) DR13 [48–62], 3 DR13 [54], DR6 305 DR6
DR11 [11–34], [12], DR11 [7],
DR6 [5–20], DR12 [6], DR5
DR14 [3–8] [4]
DRB1*1306 DR13 DR13(6) DR13 [95] 1 DR13 [88], DR6 8 DR13

[12]b
DRB1*1307 DR13 DR13(6) – – DR13 [100]b 1 Not assignedc NN: DR11, DR6
DRB1*1308 DR13 DR13(6) DR13 [84], DR6 [5] 1 DR13 [100]b 5 DR13
DRB1*1309 DR13 – – – DR13 [100]b 1 DR6f NN: DR13
DRB1*1310 DR13 DR13(6) DR13 [80–95], 5 DR13 [100]b 4 DR13
DR6 [7–15],
DR14 [0–10]a
DRB1*1311 DR13 DR13(6) DR13 [72–90], 2 DR6 [50], blank 2 DR11
DR11 [0–28], [50]b
DR14 [0–10],
DR6 [0–6]a
DRB1*1312 DR13 DR13(6)d – – DR13 [50], DR6 8 DR13 DR13x12
[13], DR12 [13],
DR11 [13]b
DRB1*1313 DR13 DR13(6)d DR13 [83], DR6 1 – – DR6 DR52 negative;
[13] NN: DR13, DR8
DRB1*1314 DR13 DR13(6) DR13 [69–77], 3 DR11 [50], blank 2 DR11
DR11 [0–15], [50]b
DR14 [0–9],
DR6 [0–5]a
DRB1*1315 DR13 – – – – – DR13
DRB1*1316 DR13 DR13(6) – – – – DR13
DRB1*1317 DR13 DR13(6) DR13 [53], DR8 1 – – Not assignedc DR13x8; NN: DR8
[41], DR11 [6]a
DRB1*1318 DR13 DR13(6) – – – – Not assignedc NN: DR6, DR11
DRB1*1319 DR13 DR13(6)d – – – – DR13 NN: DR14
DRB1*1320 DR13 DR13(6) DR13 [87–95], 2 – – DR13
DR6 [0–5]a
DRB1*1321 DR13/DR11 – – – DR13 [50], blank 2 DR11
[50]b
DRB1*1322 DR13 DR13(6)d – – DR13 [100]b 1 DR13f NN: DR6
DRB1*1323 DR13 – – – – – DR13 NN: DR6
DRB1*1324 DR11 – – – – – DR11
Table 4 Continued
DRB1*1325 DR11 – – – – – DR11

DRB1*1326 DR14 – – – – – DR14 DR blank DR52

positive
DRB1*1327 DR13 DR13(6) – – – – DR13
DRB1*1328 DR13 – – – – – DR13
DRB1*1329 DR13 DR13(6)d DR13 [72–90], 2 – – DR13
DR6 [0–9]a
DRB1*1330 Undefined – – – – – Not assignedc NN: DR13, DR6,
DR11
DRB1*1331 DR13 – DR13 [80], DR14 1 – – DR13
[10]a
DRB1*1332 DR13 – – – – – DR13
DRB1*1333 DR13 – – – – – DR13
DRB1*1334 DR13 – – – – – DR13
DRB1*1335 DR13 – – – – – DR13
DRB1*1336 DR13 DR13(6) DR13 [91–100], 3 DR6 [100]b 1 DR13
DR6 [0–5],
DR14 [0–4]a
DRB1*1337 DR13 – – – – – DR13
DRB1*1338 DR13 – – – – – DR13
DRB1*1339 DR13 – – – – – DR13
DRB1*1340 DR13 – – – – – DR13
DRB1*1341 DR13 – – – – – DR13
DRB1*1342 DR6 DR13(6) – – – – DR6
DRB1*1343 DR13 – – – – – DR13
DRB1*1345 DR13 – – – – – DR13
DRB1*1346 DR11 – – – – – DR11
DRB1*1348 DR13 – – – – – DR13
DRB1*1349 DR6 – – – – – DR6
DRB1*1350 DR11 – – – – – DR11
DRB1*1351 DR13 – – – – – DR13
DRB1*1352 DR13 DR13(6) – – – – DR13
DRB1*1353 DR13 – – – – – DR13
DRB1*1354 DR14 DR14(6) – – – – Not assignedc NN: DR11
DRB1*1355 Undefined – – – – – Not assignedc NN: DR8, DR6
DRB1*1356 DR6 – – – – – DR6 NN: DR13
DRB1*1357 DR13 DR13(6) – – – – DR13
159
Table 4 Continued
160
DRB1*1358 DR13 – – – – – DR13

DRB1*1359 DR13 – – – – – DR13
DRB1*1360 DR6 – – – – – DR6 DRB5*02
associated (60)
DRB1*1361 DR13 – – – – – DR13
DRB1*1362 DR11 – – – – – DR11

DRB1*1363 DR13 – – – – – DR13
DRB1*1364 DR13 – – – – – DR13
DRB1*1365 DR13 – – – – – DR13
DRB1*1366 DR13 DR13(6) – – – – DR13
DRB1*1367 DR13 – – – – – DR13
DRB1*1368 DR13 – – – – – DR13
DRB1*1369 DR13 – – – – – DR13
DRB1*1370 DR13 – – – – – DR13
DRB1*1371 DR13 – – – – – DR13
DRB1*1372 DR13 – – – – – DR13
DRB1*1373 DR13 – – – – – DR13
DRB1*1374 DR13 – – – – – DR13
DRB1*1375 Undefined – – – – – Not assignedc NN: DR11, DR13,
DR6
DRB1*1376 DR13 – – – – – DR13
DRB1*1378 DR13 – – – – – DR13
DRB1*1379 DR13 – – – – – DR13
DR6 [0–7]a [14], DR13 [3]
DR6 [12–17], [13], DR13 [9]
DR17 [8–15],
DR13 [0–19]
DRB1*1403 DR1403/DR14 DR1403 – – DR14 [72], DR6 37 DR14
[12]
DRB1*1404 DR1404/DR14 DR1404 DR14 [84–89], 8 DR14 [79], DR6 80 DR14
DR1404 [5–8], [8], DR1404 [3]
DR6 [3–7], DR8
[0–10]
DRB1*1405 DR14 DR14(6) DR14 [74–85], 2 DR14 [86], DR6 58 DR14
DR6 [11–15], [10]
DR3 [0–13]
Table 4 Continued
DRB1*1406 DR14 DR14(6) DR13 [28], DR14 1 DR14 [37], DR13 117 Training – DR6 DR14
[26], DR6 [19], [22], DR6 [15]

DR3 [11]
DRB1*1407 DR14 DR14(6) DR14 [87–96], 2 DR14 [94]b 16 DR14
DR6 [0–4]a
DRB1*1408 DR14 DR14(6)d DR14 [94] 1 DR14 [50], DR6 4 DR14
[25]b
DRB1*1409 DR14 – – – – – DR14
DRB1*1410 DR14 DR14(6) DR14 [76–83], 2 DR14 [100]b 4 Not assignedc NN: DR4, DR14,
DR6 [4–10] DR6
DRB1*1411 DR14 DR14(6) DR14 [59], DR6 1 DR14 [100]b 1 Not assignedc DR14x11; NN:
[12], DR11 [12], DR14
DR‘14x11’ [9]
DRB1*1412 DR14 DR14(6) – – – – DR14 NN: DR6
DRB1*1413 DR14 DR14(6) DR14 [59–86], 3 DR6 [100]b 1 DR14
DR6 [4–17],
DR13 [0–10]
DRB1*1414 DR14 DR14(6) DR14 [88–89], 2 – – DR14
DR13 [0–5]
DRB1*1415 DR8 DR8 DR8 [50], DR14 1 DR8 [100]b 1 DR8 DR8 1 DR52
[26], DR13 [8]
DRB1*1416 DR6 DR6 – – DR14 [100]b 1 DR13 DR14x13
DRB1*1417 DR6 DR6 – – DR13 [100]b 1 DR6 DR14x13; DR13
weak, DR14
negative
DRB1*1418 DR14 DR6 – – DR14 [100]b 1 DR14
DRB1*1419 DR14 DR14(6) – – – – DR14
DRB1*1420 DR14 DR14(6) – – Blank [100]b 1 DR14
DRB1*1421 DR14 DR14(6) DR14 [57–84], 3 DR6 [100]b 1 DR6 Also typed as
DR13 [8–29], DR13
DR6 [4–14],
DR17 [0–6]a
DRB1*1422 DR14 DR14(6)d – – – – DR14
DRB1*1423 DR14 – – – DR14 [100]b 1 DR14
DRB1*1424 DR14 – – – – – DR14
DRB1*1425 DR6 – – – – – DR6
DRB1*1426 DR14 DR14(6) – – – – DR14
DRB1*1427 DR14 DR14(6) – – – – DR6 NN: DR14
DRB1*1428 DR14 – – – – – DR14
161
Table 4 Continued
162
DRB1*1429 DR14 DR14(6) – – – – DR14

DRB1*1430 DR6 – – – – – DR6
DRB1*1431 DR14 – – – – – DR14
DRB1*1432 DR14 – – – – – DR14
DRB1*1433 DR6 – – – – – DR6 NN: DR14
DRB1*1434 DR14 – – – – – DR14

DRB1*1435 DR14 – – – – – DR14
DRB1*1436 DR14 – – – – – DR14
DRB1*1437 DR14 – – – – – DR14
DRB1*1438 DR14 – – – – – DR14
DRB1*1439 DR14 – – – – – DR14
DRB1*1440 DR14 – – – – – DR14
DRB1*1441 DR14 – – – – – DR14
DRB1*1443 DR14 – – – – – DR14
DRB1*1444 DR14 – – – – – DR14
DRB1*1445 DR14 – – – – – DR14
DRB1*1446 DR14 – – – – – DR14
DRB1*1447 DR14 – – – – – DR14
DRB1*1448 DR14 – – – – – DR14
DRB1*1449 DR14 DR14(6) – – – – DR14
DRB1*1450 DR14 DR14(6) – – – – Not assignedc NN: DR14, DR6
DRB1*1451 DR14 – – – – – DR14
DRB1*1452 DR14 – – – – – DR14
DRB1*1453 DR13/14 DR13(6) – – – – DR11
DRB1*1454 DR14 – DR14 [100]a 3 DR14 [89]b 9 DR14
DRB1*1455 DR14 – – – – – DR14
DRB1*1456 DR14 – – – – – DR14
DRB1*1457 DR4/DR6 – – – – – DR4 NN: DR6
DRB1*1458 DR14 – – – – – DR14
DRB1*1459 DR14 – – – – – DR14
DRB1*1460 DR14 DR14(6) – – – – DR14
DRB1*1461 DR14 – – – – – DR14
DRB1*1462 DR14 – – – – – DR14
DRB1*1463 DR6 – – – – – DR6f NN: DR14
DRB1*1464 DR14 – – – – – DR14
DRB1*1465 DR6 – – – – – DR6f NN: DR14
DRB1*1466 DR14 – – – – – DR14
DRB1*1467 DR6 – – – – – DR6f NN: DR14
Table 4 Continued
DRB1*1468 DR14 – – – – – DR14

DR2 [0–19], [23]
DR16 [0–13]a
DR2 [0–14]a [16]
DR2 [3–13], [13]
DR16 [0–6]a
DRB1*1504 DR15 DR15(2)d DR15 [76–91], 4 DR15 [100]b 1 DR15
DR2 [0–18],
DR16 [0–6]a
DRB1*1505 DR15 DR15(2) – – DR15 [100]b 1 DR15
DRB1*1506 DR15 DR15(2) – – DR15 [100]b 2 DR15
DRB1*1507 DR15 DR15(2)d DR15 [82–91], 2 – – DR15
DR2 [5–9],
DR16 [0–9]a
DRB1*1508 DR15 DR2 – – – – DR15
DRB1*1509 DR15 – – – – – DR15
DRB1*1510 DR2 – – – – – DR2 NN: DR15
DRB1*1511 DR15 – – – – – DR15
DRB1*1512 DR15 – – – – – DR15
DRB1*1513 DR2 – – – – – DR2 NN: DR15, DR16
DRB1*1514 DR15 – – – DR15 [100]b 1 DR15
DRB1*1515 DR15 – – – – – DR15
DRB1*1516 DR15 – – – – – DR15
DRB1*1517N Not expressed Null – – – – NT
DRB1*1518 DR15 – – – – – DR15
DRB1*1519 DR15 – – – – – DR15
DRB1*1520 DR15 – – – – – DR15
DRB1*1521 DR2 – – – – – DR2f NN: DR15, DR16
DRB1*1522 DR15 – – – – – DR15
DRB1*1601 DR16 DR16(2) DR16 [31], DR15 1 DR16 [41], DR2 703 Training – DR2 DR16
[38], DR2 [31] [29], DR15 [19]
DR2 [12–28], [30], DR15 [16]
DR15 [6–22]a
DRB1*1603 DR16 DR2 – – – – DR16
163
NMDP database; some individuals carried the allele but did
not have associated serologic typing. In some cases, the
Comments
number of cells tested is less than the number in the last
dictionary. In these cases, the typing assignment may have
changed or further data suggest that the typing result was
not informative.
Assigned type >0.55
Neural network
An artificial NN was used to predict serologic assignments
for alleles lacking this information and to support serologic
assignments from other sources (7). The same set of alleles
DR16
DR16
DR16
DR16
DR16
DR16
DR16
used in previous iterations was used to train the NN. The

NN
training alleles and the broad and split serologic assign-

ments used in the training are indicated in the tables. In this
Cells tested
2008 report, 10 NN were run instead of the five previously

run to increase accuracy of the predictions. After training of
10 independent NN for each locus, the NN were used to
1
1
–
–
–
–
–
predict the serologic types associated with polymorphic

amino acid sequences of the remaining allelic products and
Assigned type [%]
results summarized from the 10 networks. Primary assign-

ments are listed in one column, secondary assignments in the
DR16 [100]b
DR16 [100]b
‘Comments’ column. The criteria used for inclusion are

NMDP
described in the 2004 dictionary. Some allelic products with

unusual combinations of serologic epitopes did not receive
–
–
–
–
–
an assignment from the NN or have received varying

assignments in the different published iterations of the
Cells tested
International Cell Exchange, UCLA
network analysis. For example, A*0255, an allele evaluated

in all three iterations of the NN received varying assign-
ments from the NN. In the first NN (7), A2 was assigned as
2
–
–
–
–
–
–
the primary specificity with A28 and A69 as secondary

Assigned type [%]
specificities; in the second NN (4), A28 was primary with

DR15 [16–27],
A69 as secondary; and in this iteration summarizing 10 NN,

DR16 [53–64],
DR2 [9–31]a
no specificity was assigned (serologic blank) and A2, A69,

and A28 were assigned as secondary specificities.
It should be noted that a few cases were observed where
–
–
–
–
–
–
the NN did not assign the same serologic specificity as

expected based on the validation data set. For example,
B*1529 was assigned as B71 by the NN when previously this

WHO assigned
allele had been assigned as B15 by serology. This

discrepancy could be because of limited serologic typing
DR16(2)d
DR16(2)
DR16(2)
data or because of limitations of the NN prediction. The

data from the NN can be viewed at http://bioinformatics.

–
–
–
–
nmdp.org/neuralnetwork2007.
The use of a NN to predict the serologic assignments of
Expert assigned
antigens encoded by the HLA-C and -DQB1 loci is new. The

alleles with well-defined serology used to train the NN and
to validate the network assignments are indicated in
DR16
DR16
DR16
DR16
DR16
DR16
DR16
Tables 3 and 6.
Table 4 Continued
Serology allele phenotype component of the 13th

DRB1*1604
DRB1*1605
DRB1*1607
DRB1*1608
DRB1*1609
DRB1*1610
DRB1*1611
International Histocompatibility Workshop

HLA allele
The data from the 13th IHWG were obtained by serologic

typing of cells with known HLA alleles. The cells were
b
e
a
Table 5 HLA-DRB3, DRB4, DRB5 alleles and their serologic designations
International Cell Exchange, UCLA International Cell Exchange, UCLA

Expert WHO Expert WHO
HLA allele assigned assigned Assigned type [%] Cells tested Comments HLA allele assigned assigned Assigned type [%] Cells tested Comments
DRB3*0101 DR52 DR52 DR52 [90–100]a 88 DRB3*0222 Undefined – –

DRB3*0102 DR52 – DR52 [99] 1 DRB3*0301 DR52 DR52 DR52 [90–100]a 41

DRB3*0103 Undefined – – – DRB3*0302 DR52 DR52 – –
DRB3*0104 Undefined – – – DRB3*0303 DR52 – DR52 [100]a 1
DRB3*0105 Undefined – – – DRB4*0101 DR53 DR53 DR53 [94–100]a 44
DRB3*0106 DR52 DR52 – – DRB4*0102 Undefined – – –
DRB3*0107 DR52 DR52 – – DRB4*0103 DR53 DR53 DR53 [88–100]a 73
DRB3*0108 Undefined – – – DRB4*01030102N Not expressed Null Refer to comments 23 DR53 (20–54), false-
positive assignments
DRB3*0109 Undefined – – – DRB4*0104 Undefined – – –
DRB3*0110 DR52 DR52 – – DRB4*0105 DR53 DR53 – –
DRB3*0111 Undefined – DRB4*0106 Undefined – – –
DRB3*0201 DR52 DR52 DR52 [97–100]a 3 DRB4*0107 Undefined –
DRB3*0202 DR52 DR52 DR52 [90–100] 126 DRB4*0201N Not expressed Null – –
DRB3*0203 DR52 DR52 DR52 [100] 1 DRB4*0301N Not expressed Null Refer to comments 1 DR53 (69) false-positive
assignments
DRB3*0206 DR52 – DR52 [91]a 1 DRB5*0103 Undefined – – –
DRB3*0210 DR52 DR52 – – DRB5*0107 DR51 DR51 – –
DRB3*0211 DR52 DR52 – – DRB5*0108N Not expressed Null Refer to commentsa 2 DR51 (43–60), false-
positive assignments
DRB3*0213 Undefined – – – DRB5*0110N Not expressed Null Refer to commentsa 1 DR51 (55), false-positive
assignments
DRB3*0214 Undefined – – – DRB5*0111 Undefined –
DRB3*0221 Undefined – – –
a
165
Table 6 HLA-DQB1 alleles and their serologic designations
International Cell Exchange,

UCLA NMDP NN

HLA allele assigned assigned Assigned type [%] tested Assigned type [%] tested type >0.55 Comments
a
DQB1*0201 DQ2 DQ2 DQ2 [87–100] 30 DQ2 [98] 9175 Training – DQ2
DQB1*0202 DQ2 DQ2 DQ2 [75–100]a 23 DQ2 [87] 656 DQ2
DQB1*0203 DQ2 DQ2 – – DQ2 [67]b 3 DQ2
DQB1*0204 DQ2 – – – – – DQ2
DQB1*0205 DQ2 – – – – – DQ2
DQB1*0301 DQ7 DQ7(3) DQ7 [47–91], DQ3 71 DQ7 [85], DQ3 12,220 Training – DQ3 DQ7
[9–44], DQ8 [10], DQ8 [1]
[0–12]a
DQB1*0302 DQ8 DQ8(3) DQ3 [9–60], DQ8 37 DQ8 [66], DQ3 6687 Training – DQ3 DQ8
[24–91], DQ7 [25], DQ7 [4]
[0–20], DQ9
[0–9]a
[20–67], DQ7 [12], DQ2 [11],
[0–11], DQ8 DQ8 [1], DQ7
[0–9]a [1]
DQB1*0304 DQ7 DQ7(3) DQ7 [60], DQ3 1 DQ7 [40], DQ3 111 DQ7
[34] [35], DQ8 [8]
DQB1*0305 DQ8 DQ8(3)c – – DQ8 [34], DQ3 70 DQ8
[30]
DQB1*0306 DQ3 DQ3 – – DQ8 [100]b 1 DQ4
DQB1*0307 DQ8 – – – – – DQ8
DQB1*0308 DQ8 – – – – – DQ8
DQB1*0309 DQ7 – – – – – DQ7
DQB1*0310 DQ3 DQ8(3) – – DQ7 [100]b 1 DQ7
DQB1*0311 DQ8 – – – – – DQ8
DQB1*0312 DQ9 – – – – – DQ9
DQB1*0313 DQ7 – – – – – DQ7
DQB1*0314 DQ3 – – – – – DQ3d NN: DQ7, DQ8
DQB1*0315 DQ9 – – – – – DQ9
DQB1*0316 DQ7 – – – – – DQ7
DQB1*0317 DQ9 – – – – – DQ9
DQB1*0318 DQ8 – – – – – DQ8
DQB1*0319 DQ7 – DQ7 [91], DQ3 [9]a 1 – – DQ7
DQB1*0320 DQ9 – – – – – DQ9
DQB1*0401 DQ4 DQ4 DQ4 [88–89]a 3 DQ4 [71], DQ3 142 DQ4
[10]
DQB1*0402 DQ4 DQ4 DQ4 [77–100]a 22 DQ4 [86], DQ3 [2], 1085 Training – DQ4
blank [7]
[20–63], DQ6 [20], DQ6 [2]
[0–13]a
DQB1*0502 DQ5 DQ5(1) DQ1 [44–70], DQ5 20 DQ5 [48], DQ1 919 DQ5
[10–38], DQ6 [24], DQ6 [15]
[9–37]a
[9–18], DQ6 [22], DQ6 [4]
[0–27]a
DQB1*0504 DQ5 DQ5(1)c DQ1 [66], DQ5 1 DQ5 [58], DQ1 48 DQ5
[23], DQ6 [8] [17], DQ6 [2]
DQB1*0505 DQ5 – – – – – DQ5
[33–40], DQ5 [23]
[10–11]a
Table 6 Continued
International Cell Exchange,

UCLA NMDP NN

HLA allele assigned assigned Assigned type [%] tested Assigned type [%] tested type >0.55 Comments
[18–64], DQ5 [30], DQ5 [1]
[0–12]a
[22–63], DQ5 [23], DQ5 [2]
[0–10]a
[40–44], DQ5 [27], DQ5 [2]
[0–20]a
DQB1*0605 DQ6 DQ6(1) – – DQ6 [76], DQ1 358 DQ6
[13]
DQB1*0606 DQ5 – – – DQ5 [100]b 1 DQ5
DQB1*0607 DQ6 – – – DQ1 [75], DQ6 4 DQ6
[25]b
DQB1*0608 DQ6 DQ6(1)c – – DQ6 [50], DQ1 6 DQ6 DQ6
[25], DQ5 [25]b
[27–44], DQ5 [32], DQ5 [3]
[0–6]a
DQB1*0610 DQ1 – – – DQ1 [100]b 1 DQ6
DQB1*0611 DQ1 DQ1 – – – – DQ6
DQB1*0612 DQ1 DQ1 – – – – DQ6
be
DQB1*0613 DQ6 – – – 1 DQ6
DQB1*0614 DQ6 DQ6(1) – – – – DQ6
DQB1*0615 DQ6 – – – – – DQ6
DQB1*0616 DQ6 – DQ6 [33–56], DQ1 2 – – DQ6
[32–56], DQ5
[6–11]a
be
DQB1*0617 DQ6 – – – 1 DQ6
DQB1*0618 DQ6 – – – – – DQ6
DQB1*0619 DQ6 – – – – – DQ6
DQB1*0620 DQ6 – – – – – DQ6
DQB1*0621 DQ6 – – – – – DQ6
DQB1*0622 DQ6 – – – – – DQ6
DQB1*0623 DQ6 – – – – – DQ6
DQB1*0624 DQ6 – – – – – DQ6
DQB1*0625 DQ6 DQ6(1) – – – – DQ6
DQB1*0626N Not expressed Null – – – – NT
DQB1*0627 DQ6 – – – – – DQ6
DQB1*0628 DQ6 – – – – – DQ6
DQB1*0629 DQ6 – – – – – DQ6
DQB1*0630 DQ6 – – – – – DQ6
DQB1*0631 DQ6 – – – – – DQ6
DQB1*0632 DQ6 – – – – – DQ6
DQB1*0633 DQ6 – – – – – DQ6
a
b
Updated NMDP data. In some cases, the information reported in previous dictionaries has changed. Cells have been excluded from this study in some
cases because their HLA typing has changed.
c
d
e
tested with a common set of well-characterized reagents Some alleles in the tables are listed with more than one
including mainly monoclonal antibodies (12) and supple- common serological assignment. This indicates that the
mentary allosera. Tables 1–3 show the number of panel serological pattern is not clear, for example B*4416 has both
cells for each allele included in the analysis, the assigned B47 and B44 reactivity. The ‘Comments’ section may
specificity and, where appropriate, comments on the sero- provide further information for serological reactivity in
logical expression of that allele, as reported by the 13th some cases. In addition, many laboratories are not able to
IHWS serology and HLA phenotype component (8, 9). identify many of the WHO-designated HLA specificities.
These data have not been updated from the 2004 edition of The International Cell Exchange, UCLA data show that
the HLA data dictionary. some of the newer specificities are rarely used but are often
designated by their antigen equivalents, for example A2
Information obtained from other sources instead of A203. Although subsequent cell exchanges do
improve the detection rate, these assignments remain
Data on the serological expression of new alleles have been difficult. It is useful to refer to the percentage recogni-
submitted from HLA laboratories. However, because many tion information when selecting alternative antigens for
laboratories no longer perform serological typing or use alternative searches.
commercial monoclonal reagents, there are only a small
number of alleles that have been tested in this way. In this
Searchable links between alleles and serologic
edition of the dictionary, only 23 HLA class I alleles have
assignments
been submitted with serological information. The ‘Com-
ments’ column in the tables refers to information from A searchable form of the dictionary is available through the
publications (listed at end of document) and other sources IMGT/HLA database (5) at http://www.ebi.ac.uk/imgt/
that describe serologic expression of new alleles. It must be hla/. This information can then be used by HSC registries to
noted, however, that some of these data are based on small routinely update their matching algorithms and to support
sample numbers tested by a single laboratory. other search and matching activities.
Expert assigned type Acknowledgments

The expert assigned type for HLA-A, -B, -C, -DRB1, -DRB This work was supported in part by the US Office of Naval
3/4/5, and -DQB1 alleles is the combination of all serologic Research N00014-05-1-0859 to the NMDP (MS, MM, and
equivalents information. This may help identify serologic JK) and N00014-06-1-0726 to the C.W. Bill Young Marrow
equivalents when there are differences with the WHO HLA- Donor Recruitment and Research Program (CKH). The
designated serologic assignments (e.g. B*4005), or where participants of the International Cell Exchange, UCLA and
multiple assignments are possible such as hybrid molecules, the Transplantation and Immunogenetics Laboratory of
or where more antigen assignments are given (e.g. A* 3204, the Welsh Transfusion Service are acknowledged for their
Table 1 and B*1303, B*1304, Table 2). Occasionally, the contribution.
expert assigned type is based on the NN assignment;
however, while this should be considered with caution, the
NN may be the only information available. References
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Immunogenetic study of a new HLA allele B*2723. Tissue HLA-B*4431: a new HLA-B variant with a complex ancestral
Antigens 2002: 60: 400–3. history involving HLA-B*44, B*40 and B*07 alleles. Tissue
38. Elsner H-A, Himmel A, Steitz M et al. HLA-B*3531, a hybrid Antigens 2002: 60: 91–4.
of B35 and B61, implications for diagnostic approaches to 51. Poli F, Longhi E, Frison S et al. Identification of a novel
alleles with complex ancestral compositions. Tissue Antigens HLA-B allele – HLA-B*4902. Tissue Antigens 2001: 57: 173–4.
2002: 60: 95–7. 52. Darke C, Street J, Guttridge MG. Sequence, genetics and
39. Swelsen WTN, Voorter CEM, van den Berg-Loonen EM. serology of a new HLA-B allele: B*4903. Tissue Antigens 2001:
Sequence analysis of exons 1, 2, 3, 4 and 5 of the 57: 478–80.
HLA-B5/35 cross-reacting group. Tissue Antigens 2002: 53. Voorter CEM, Hepkema BG, Mulkers EMT, Lems SPM, van
60: 224–34. den Berg-Loonen EM. Identification of two new HLA-B22
40. Estefania E, Gomez-Lozano N, de Pablo R, Moreno ME, variants, HLA-B*5509 and B*5606. Tissue Antigens 2001:
Vilches C. Complementary DNA sequence of the novel 58: 42–6.
HLA-B*3704 allele. Tissue Antigens 2002: 59: 142–4. 54. Park H-S, Choi J-H, Lee KW. Identification of a novel
41. Pyo C-W, Han H, Kim T-G. Identification of a new HLA-B HLA-B*55 variant (B*5513) from a Korean family. Tissue
allele, B*3705, containing a Bw6 sequence motif. Tissue Antigens 2004: 64: 96–8.
Antigens 2002: 59: 335–7. 55. Lyou J-Y, Yang KL, Lee A, Lin PY, Lee TD. Confirmation of
42. Garcia-Sanchez F, Fernandez-de-Velasco J, Lillo R et al. a recombinant allele B*5603 and a hypothetical reciprocal
Two new HLA class I alleles recognised by PCR-SSP hybrid. Eur J Immunogen 2002: 29: 69–71.
and SBT: B*3805 and Cw*0408. Tissue Antigens 2002: 59: 56. Wu G-G, Cheng L-H, Zhou D et al. Identification of a novel
47–8. allele HLA-B*5610 in a Chinese potential bone marrow donor.
43. Voorter CEM, van den Berg-Loonen EM. Sequence based Tissue Antigens 2003: 61: 256–8.
typing of exons 1-5 of a new HLA-B allele, B*3927. Tissue 57. Poli F, Crespiatico L, Frison S, Longhi E, Marlianici E,
Antigens 2004: 63: 480–3. Scalamogna M. HLA-B*5808, a new HLA-B allele
44. Blanco PV, Theile G, Marcos C, et al. Novel HLA allele, characterized by sequence based typing. Tissue Antigens 2003:
HLA-B*4013, identified from a potential bone marrow 62: 551–3.
recipient. Tissue Antigens 2001: 57: 380–3. 58. Cantwell L, Boyle A, Diviney M et al. Identification of two new
45. Voorter CEM, Hepkema BG, Lems SPM, van den Cw alleles – implication for epitope recognition (ASHI
Berg-Loonen EM. Identification of a new HLA-B*40 variant abstract). Hum Immunol 2002: 63: S37.
B*4035. Tissue Antigens 2003: 61: 89–91. 59. Voorter CEM, Fischer GF, van den Berg-Loonen EM.
46. Peräsaari JP, Koskela S, Partanen J. Characterization a novel Identification of a new HLA-C allele, Cw*0316, by SBT.
HLA-B40 allele with serological Bw4 motif, HLA-B*4047, in Tissue Antigens 2004: 63: 484–6.
the Finnish population and confirmation of B*270503 allele. 60. Testa GV, Bunce M, Sheldon MH, Dunn PPJ, Day S, Marques
Tissue Antigens 2004: 63: 595–7. SBD. Identification of a new allele, HLA-DRB1*1360, on
47. Street J, Downing J, Darke C. Immunogenetics of the a DRB5 haplotype in a Brazilian individual. Tissue Antigens
rare HLA-B allele B*4408. Eur J Immunogen 2003: 2004: 63: 617–8.
30: 129–31. 61. Hammond L, Bengtsson M, Street J et al. HLA-A*2312-a
48. Darke C, Street J, Downing J. Immunogenetics of two new novel allele found in testing for the UK NEQAS H & I DNA
HLA-B alleles: B*4414 and B*5708. Tissue Antigens 2003: HLA typing scheme. Tissue Antigens 2006: 68: 175–6.
62: 436–41. 62. Dubois V, Tiercy JM, Labonne MP, Dormay A, Gebuhrer L.
49. Canossi A, Papola F, Liberatore G et al. Identification of the A new HLA-B44 allele (B*4402012S) with a splicing mutation
novel allele B*4427 and a confirmatory sequence (B*44022). leading to a complete deletion of exon 5. Tissue Antigens 2004:
Tissue Antigens 2002: 59: 331–4. 63: 173–80.

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Tissue Antigens ISSN 0001-2815

The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/

Key words Abstract

WHO Cells Assigned Cells Cells Assigned

WHO Cells Assigned Cells Cells Assigned

A*0205 A2 A2 A2 [100] 5 A2 [81] 462 A2 10 Training – A2

WHO Cells Assigned Cells Cells Assigned

A*0243N Not expressed Null – – – – – – NT

WHO Cells Assigned Cells Cells Assigned

A*0278 Undefined A2 – – – – – – Not assignede NN: A69, A28

WHO Cells Assigned Cells Cells Assigned

WHO Cells Assigned Cells Cells Assigned

A*0321N Not expressed Null – – – – – – NT

WHO Cells Assigned Cells Cells Assigned

A*1123 A11 – – – – – – – A11

WHO Cells Assigned Cells Cells Assigned

WHO Cells Assigned Cells Cells Assigned

A*2434 A24 – – – – – – – A24

WHO Cells Assigned Cells Cells Assigned

A*2471 A24 – – – – – – – A24

A*2474 A24 – – – – – – – A24

WHO Cells Assigned Cells Cells Assigned

A*2616 A26 – – – A26 [100]c 1 – – A26

WHO Cells Assigned Cells Cells Assigned

WHO Cells Assigned Cells Cells Assigned

A*3108 A31/A24 – – – A32 [100]c 1 – – Not assignede A31x24; previously

WHO Cells Assigned Cells Cells Assigned

A*3309 Undefined A19 – – – – – – Not assignede NN: A31, A33

WHO Cells Assigned Cells Cells Assigned

WHO Cells Assigned Cells Cells Assigned

A*6818N Not expressed Null – – – – – – NT

ihw13: difficult to type

relation between alleles and serologic assignments. Readers

are referred to previous versions of the dictionary that des-

In this version, data for alleles serologically typed in 20 or

remain the same as that shown in the 2004 dictionary (4).

For these alleles, we believe that adequate data have been

accumulated to define the serologic assignments.

A subset of the EM data including the alleles with counts of

alleles was analyzed. The EM algorithm provides an unbiased

assignment of serologic specificities using information from

all cells carrying the allele in question. In addition, experts

reviewed the serologic assignments for all cells carrying an

Uninformative cells were eliminated and known serologic

cross-reactivity was considered in the assignment. The

information from the EM algorithm and the results from

the review were compared and final serologic assignments

ments and the percent of informative individuals carrying

those assignments. The percentages listed in the table are

derived from the review of typings as described above; this

differs from previous years in which the percentages were

A80 [68–88], A36

reflect the serologic assignment of these less frequent alleles.

The allele has been identified but serology not informative.

serologic assignment. For example, cells carrying both

A*0201 and A*0208 frequently appear. The EM assignment

Updated International Cell Exchange, UCLA.

eliminated these uninformative cells (i.e. carrying both

A*0201 and A*0208) resulting in an A2 assignment for

The information for 454 alleles, including 122 HLA-A,

200 -B, 50 -C, 73 -DRB1, and 9 -DQB1, was reviewed and

a footnote in the tables. If an allele appears five times or less,

the serologic assignment(s) should be considered as only an

approximation of the serologic reactivity of the resultant

A0201 and A0208 frequently appear. The EM assignment

A0201 and A0208) resulting in an A2 assignment for

B4019 B61 – – – – – B‘4019’ 1 Not assignede B40Bw4, B4002