Pharmaceutical necessities

In addition to the active ingredient (s)– a series of substances are

normally included in pharmaceutical preparations known as
pharmaceutical necessities.
Most common pharmaceutical necessities are-
- Diluent
- Vehicle
- Binder
- Taste imparting agents
- Disintegrates
- Color
- Flavor
- Antioxidant
- Preservative etc.
Excipients Used in Solid Dose
Formulations
 Factors governing the
selection of excipients
• They must be nontoxic and acceptable to
regulatory agencies
• They must be commercially available
• Their cost must be acceptably low
• They must not be contraindicated in any
segment of population. e.g. sucrose,
sodium etc.
• They must be physiologically inert
 Factors governing the
selection of excipients
• They must be physically & chemically
stable
• Free from unacceptable
microbiological load
• They must be color compatible (not
produce any off-color appearance)
 Factors governing the
selection of excipients
• No deleterious effect on
bioavailability of drug
• Should be compatible with the type
of product