Pathophysiology of the Disease Process

Risk Factor Etiologic Factor

Destruction of pigmented
neuronal cells

Host Agent Environment

Θ Genes Θ Herbicide Θ Rural area Decreased dopamine stores

Θ Caucasians Θ Pesticide Θ Used of
Θ Age (60 Θ Fungicide water well
and above) Θ Drug by for cooking,
Degeneration of the
Θ Male product and drinking
dopaminergic nigrostriatal
Θ Head Θ Cyanide
pathway
trauma Θ Carbon
Θ Declining monoxide
estrogen Θ Mercury
levels Θ Copper Imbalance of excitatory and
Θ Farmer Θ Decreased inhibitory neurotransmitters in
levels of the corpus striatum
Vitamin B

Impairment of the extrapyramidal

tracts controlling complex body
movements

Degeneration

Systems
Affected

Genitourinary Psychological Muscular Digestive

Θ Urinary Θ Dementia Θ Tremor Θ Constipation

incontinence Θ Depression Θ Rigidity
Θ Impaired Θ Mood Θ Akinesia
sexuality alterations Θ Expressionless
Θ Bladder Θ Slurred speech
control Θ Postural
changes
Θ Shuffling gait
Θ Dysphagia
Θ Choking and
ASPIRATION
Pathophysiology of the Disease Process

Aspiration of secretions Complications

 Respiratory and
urinary tract
Activation of defense infections
mechanism  Impaired
Thinking
(Cognitive
Impairment)
Lose effectiveness of defense  Vision
mechanism Problems.
 Impaired
Sexuality
 Worsened Sense
Penetrate the sterile lower of Smell
respiratory tract (lungs)  Ataxia

Multiplication of bacteria

Colonization

Release damaging toxins

Infection

Inflammation

ASPIRATION PNEUMONIA