THEORETICAL PSYCHOPATHOLOGY

Schizophrenia

Biologic Theories

Genetic Factors Neuroanatomic/Neurochemical Factors Immunovirologic Factors

Twin Studies Adoption Studies Family Studies

Monozygotic Dizygotic Biological Parent Immune Response Virologic Factors

(Identical) (Fraternal)

One Parent Both Parents

Cytokines Influenza
50% risk 15% risk
15% risk 35% risk
Pregnant Women
Produces behavioral
and neurochemical
changes BBB

Newborn is possible
to develop
schizohophrenia
 Neuroanatomic Factors Neurochemical Factors

Imaging Techniques Intrauterine Influences

CT Scan MRI PET Decreased brain volume

and abnormal brain Poor nutrition alcohol stress
function in the frontal
and temporal areas
Less brain tissue and CSF tobacco drugs

Failure in development (+) signs (-) signs

or subsequent loss of
tissue
Temporal lobe Frontal lobe

Enlarged ventricles in Glucose metabolism and psychosis Lack of volition,

the brain and cortical oxygen are diminished in motivation and
atrophy the frontal cortical anhedonia
structures of the brain
dopamine serotonin norepinephrine acetylcholine glutamate

Amphetamine/ Controls excessive

levodopa dopamine

Induces paranoid Excessive serotonin

psychotic
reaction
Hallucinations,
delusions,
withdrawn behavior