Inhalation

of Mycobacterium tuberculosis

Lung

Inflammatory Response
Individual Tuberculosis Formation
Delayed Hypersensitivity
v Reaction With HIGH resistance - ceseation necrosis and granuloma

- organism walled off (Ghon Complex)

Positive Individual with

Tuberculin With LOW resistance SECONDARY OR REINFECTION
Test
IF resistance decreases later

(immune suppression)
Bacilli to lymph nodes
Type IV -organisms reactivated
Immune response

Cavitation

Active Infection

Dissemination through

Lungs and other organs

Tuberculosis is once thought to be declining and well under control.

Tuberculosis is usually caused by Mycobacterium tuberculosis and affects primarily the lungs but the
pathogen may invade other organs as well. Mycobacterium tuberculosis is an acid – fast, aerobic, slow
growing bacillus that is somewhat resistant to drying and some disinfectants.

- They are destroyed by:

Ultraviolet light
Heat
Alcohol
glutaraldehyde