\ Paraventricular ", ucfeus

A

Post:,eri,of' Piitu itary ,(iN,e'uro,hYiPOphysis)

OXYTOCIN

C:HO

N~-L um &_~"0..'§r.~ :1: ~·t-COOH NH21 t·:, : IDIIII 1111 III 0 lIHlI1 II [J-COOH

Signall Arg1inine Neuro- Glylco~

PepUde Vaso- phys,in II pe,ptide

pressin

Signall Oxy~ N"euro-

Peptidetocin physin I

.,

[J-G,ly IIUlI\lUBIIUnlnllll1

'.

__ NH2,

Alr'g'inine,B-Va,sopreS5in

NieurD~ Iphysi'n ill

Neurophysin I

•

•

GNH2

Oxytocin

Further processling

,sup1ra,op1:iIC ,or .. , .

Pa1rav.e,int(iClUIla,r iNllucleus : '

'II R ~ .. ,. _ • ~"' ..• Ii -_ ~_ I~ ., ~_.," .J.~ .~ ••• ~ ... ";;.L

-.... ~

,c1' J ElI'1Idop~asmi'c R,eticulum

1/

Go:lgi Body

»:

'. Precerscr and!

. -

PrIQces,s,jng IEnz,vmes

I ~ I _

;",';: ;:. :~o:~ ),~i.~~; ::(:';:;~>.;~":;:';:~~:'; ~:;:: ;'::-::';-f.~. :':.:

IHypotha~a'mus and Pli'tlUlitalry S:tatk

'.:::'.; :~_";-.: .~':'~.:. -: .:: .r7:";-.':'1":.,'. _ .:,.:,:":7 / <.>:'\~:.

PoS,lerio,r' IPli'lulit:a ry ._ . . . ..

'11 Propaqated Action Po'tenUa~sl

Sodium Channet

Calcium Channell

,

Transported Granule'

I

tierriing, Body

. ,.,~~

... 'II

Peptid~' " ': Membrane

Neurophysin Recapture

E

<, (jII a..

z 20 if)

U)

w

a: £L o (J)

~

<t ~ U1 <t ...J a..

o

0--0 PAVP:; 1.48 [Pcsrn ~ 284.7] ,r = 0.977 x,--:x. ThIrst: 9.06 [Posm-'293.5lr = 0.966

30

25

15

10

5

o

:0:'

/ I /' X.

I

I I X I.,.,

I

X. JJ

o

285 290 295 300 305

PLASMA OSMOLALITY mosm/kg

I X

I X I I

I

I

I"

I

14

12

10

E

u

8 tV) 0::

6 I t-

4

2

o

... ..:;.

'.

fIO'A NIEUR{:JNS

oj

ANTERIOR PIITUITARri

HVPOTHAlLAMIUS

\ ~UCKUNG

. .,_~I

. S,p~NAl CORD

l~' PiROLACTIN I SIECIRElIDN

,t,IMILK SEC'RiETllON

Cerebellllum

Optic chiasm

Left Atrial Receptors Baroreceptors

:~p :9:~ . . ®O;i:di (19 H> "'l'N'P~Of' Induc€>s

a confarrnationa,j' change

GTP in G_

., GD'P b·o .... nd IqG .. ", IS replaced by GTIP and ~h~ subunit dlssocrateS flfOfTI 'Grw

<3 ... binds ·to .. denyiyi cye~.)se" <l.oti' .... '.O!itlng synthesis 6-l' ,eAM:,P; nO,t""rnon6J! dissQc~ate'5,

(a t cAMP=depetJldent protein ki· ase

~~==~~~J __ ~~~

r - ~

_ leg u atorv Cata1v.le sub U i1 it ) S IJ b n . " S

IJnr c. ive

Phospholipas>e" C

Stol'eQpenlt!ed channels

Exterior

I E.lfldO. P.I.$lS. mh~ ~ reticulum

Pho'spl1i Gryl ~tio'n of $ll)bstr~te~

Effector _ "enz:y.rrllt'!

'S,e:CQ'!1I"d massenoer

ji,TP

o

MAP !<:j h~$e. :, j,t)tic.t ~ve'}

t7

r;::..~__ _ _ '" , ji, ~: AJ'J, kinase

l ... !:) _ _ _ c? n!,. _

.. .:~', j aCt ''iI,Ed

!I "To ~

.. :.-" .:_:'."

/I

.ligand

Cvtoso I ic

~

amain

ligand-b:i nding .s:ite·