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  • Antitusivos 1

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    Angel Eyeri Huchim Varguez
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    The document discusses antitussives and mucolytics, classifying antitussives into central and peripheral categories. Dextromethorphan is discussed as an opioid antitussive that is effective in clinical trials, does not depress ciliary activity, lacks analgesic effects or respiratory depression risk, and has a minimal risk of abuse. However, a study is referenced that found a 10-fold increase in reported dextromethorphan abuse cases among adolescents in California from 1999 to 2004, revealing an increasing trend of dextromethorphan abuse.

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    The document discusses antitussives and mucolytics, classifying antitussives into central and peripheral categories. Dextromethorphan is discussed as an opioid antitussive that is effective in clinical trials, does not depress ciliary activity, lacks analgesic effects or respiratory depression risk, and has a minimal risk of abuse. However, a study is referenced that found a 10-fold increase in reported dextromethorphan abuse cases among adolescents in California from 1999 to 2004, revealing an increasing trend of dextromethorphan abuse.

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    55 views14 pages

    Antitusivos 1

    Uploaded by

    Angel Eyeri Huchim Varguez
    The document discusses antitussives and mucolytics, classifying antitussives into central and peripheral categories. Dextromethorphan is discussed as an opioid antitussive that is effective in clinical trials, does not depress ciliary activity, lacks analgesic effects or respiratory depression risk, and has a minimal risk of abuse. However, a study is referenced that found a 10-fold increase in reported dextromethorphan abuse cases among adolescents in California from 1999 to 2004, revealing an increasing trend of dextromethorphan abuse.

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    of 14

    ANTITUSIVOS Y

    MUCOLITÍCOS
    Clasificación de los antitusivos
    1. De acción central.  Antitusivo opiáceo:
    Dextrometrofan
    2. De acción periférica.
     Antitusivo No opiáceo:
     Benzonatato

     Difenhidramina
     Broncodilatadores
    Dextrometorfano
     Análogo de la codeína
     Eficacia clínica en ensayos clínicos
    controlados.
     No deprime la actividad ciliar.
     Carece de actividad analgésica y
    capacidad de producir depresión
    respiratoria.
     Riesgo mínimo de abuso
    Dextromethorphan abuse in adolescence: an increasing
    trend: 1999-2004.
    Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA, USA.

     OBJECTIVES: To analyze the trend of dextromethorphan abuse in


    California and to compare these findings with national trends.
    DESIGN: A 6-year retrospective review.
     PARTICIPANTS: All dextromethorphan abuse cases reported
     RESULTS: A total of 1382 cases were included in the study. A 10-
    fold increase in dextromethorphan abuse cases from 1999 (0.23
    cases per 1000 calls) to 2004.
     CONCLUSIONS: Our study revealed an increasing trend
    of dextromethorphan abuse cases reported

    Bryner JK, et al. Arch Pediatr


    Adolesc Med. 2006
    Dec;160(12):1217-22

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