‘ouEtiNes FoR THE SUBMISSION OF ABSTRACTS (Paes) 1 SYROPSES (Ties) The ee aseact 00 words), weting te Rabo) anuon, eoty are nhnonesge a) Bote spect chet ot suay 1) tate metote one. parent 2) bonmaran rene tame (ite crete fees “ype carey, prleably on on eect pe ver Clean hey sna ite a resonesy to ict ait SLACK nBbor(@ new FABER may fsruige—an ala one ny bef Fractee ying th sbatmciyopsia a 8 ac: forge "Sei em (4x82) on ain paper Sandad store may be used The sbstactycose wil be rprogend Inthe ‘Volune ot aot sey at eid There: fore noi eoectons, amugen errs at mi oatacla must be acconsaied by regan ‘eva abet ne cone (bon or seae Foe war St CARORDERD BACKING ABSTRACT FORM ron nee one a mh fone Were” Cnecep Tem) Bem ose | tes interno! Mesting of ends of Cale Bioheminty Lsenioes IRREPARABLE DNA-DAMAGE BY INDUSTRIAL POLLUTANTS TW PRE-HATURE AGING, CHEMICAL CARCINOGENESIS AND CARDIAC HYPERTROPHY EXPERIMENTS AND THEORY. P.v.N Acharya: industrial Safety and Health Institute and Behavioral cybernetics Laboratory, University of Wisconsin, Madison, Wisconsin 53706 DsA-danage not accessible to existing repair enzymes appears £0 be the root cause for the three chronic @iseases: presnature aging. chenical carcinogenesis land cardiac hypertrophy. ‘The First one is caused by ionizing radiation and the second and third by chemi- cal pollutants in the environsent. Experiments have shown that the formation of oligo Gooxyribo ribo phosphosery] mclestides which increase from 3.2% to 6.4) in terms of cross linked DXA to ectal DNA in cho hepatocyte nuclei of unirradiacee hansters fron 181 to 582 days age, also increase in Y-irradiated Seweek old rata in the sane nuclei from 0.5% to 1.68 to 2.88 with 28, 3R and SR respectively." DNA-canage in unieradiated hansters 1s also follewed by drastic in~ crease in nuclear RUA's and thelr cuanylic and uridylic acid ration and 608 cell-death.* ‘Theoretical considerations show that PAK Like ben20(a) pyrene N-oxidize adenine and cytosine of DNR Leading to Starino snidazoie-S-earboranidoxine snd ethylene e=in0 carbonanidoxine and the Noni trosopyrrolidine elanolised by nitcites Tests to 5,N-teeza methylene Cysussno-G-onine fron cysomine. This aanege ray Ieee to replscztionn! apa transcriptional errors needed for Caretu? analysis of the Literary evidence suggests Nat the Tost ause of mony heart aliments is cardiac hypercropny which in turn Le ciised by Aypowia eae °9) Sirosprorie CO, particalece master and perowy acyl nets rare, #hich reduces AIP syntheris in cardia ai tochondia. Nonewe: .abs2ity of RIP to DNP-dependunt AZP=¥-snsephan apd allow in hypertrophied naare acon!