Sodium Valproate

PART-1:

Individual patient record review:

Patient designation(case number for survey)_______________________

Age ____________

Gender_____________

Days of SV treatment_______________________

SV dose and route___________________

Other medications given concurrently with SV:

Infection for which Na-valproate was given (infection diagnosed to be present by treating
doctors):

 Bipolar disorder.
 Dementia.
 Creutz feldtz-jackob disease.
 Migraine headache.
 Obesity
 Mood stabilizer.

Indeterminate(information in patient record):

_________________________________________________

Assessment of liver functions during treatment:

Test before beginning of treatment & then throughout the therapy

Yes/ No Results____________________________
Test for pancreatitis :

Yes/ No Results____________________________

Haematological test:

Yes/ No Results____________________________
Indication appropriate:

 Bipolar disorder
 Atonic Seizure
 Myoclonic seizure

Indication inappropriate:

 Dementia
 Migraine headache
 Obesity
 Mood stabilizer

Indication indeterminate _________________________

Dose & duration appropriate:

Oral:

In Uk, 600mg daily in divided doses,increased every 3 days by 200mg daily to u usual dose of

1-2 g daily(20-30mg/kg/day)

Max.dose is 2.5g daily.

In USA, an initial dose of 15mg/kg/day,increased at one week intervals by 5-10mg/kg/day

Max. dose is 60mg/kg/day

Dose of SV is from 600-1800mg daily in divided doses.

Parenteral:

SV may be administered by slow i.v infusion or injection.

Initial dose is upto 10mg/kg followed by further doses as necessary,upto a max. of 2.5g/day
For Children:

Oral:

For children more than 20 kg of weight ,dose is 400mg daily(irrespective of the wt),gradually
increased upto a max. dose of 20-30mg/kg/day

For children weighing less than 20 kg ,dose is 20mg/kg/day,gradually increased upto a max.

Dose of 40mg/kg/day.