拉呋 剂及其 备 (19-Nov-2008)

Lafutidine Tablet and its preparation method

Inventors
XIANGWU MA [+1] [-1]
CN
HUAILI JIANG
CN
Applicants
JIANGSU RUNBANG PHARMACEUTICAL
CN
Priority
CN 200710022287 A 14-May-2007
Classifications
International (2006.01): A61K 9/20; A61K 31/4523; A61K 31/4545; A61K 47/36; A61K 47/38;
A61P 1/00; A61P 1/04 [+4] [-4]
Abstract (English)
The invention relates to a compound pharmaceutical preparation, namely a lafutidine tablet
and a preparation method thereof. Lafutidine and proper additive are made into oral tablet
products; in the lafutidine tablet, the prescribed dose of each lafutidine tablet is 5mg to 20mg,
and other additional doses are listed as follows: 10 to 50 percent of lactose, 5 to 30 percent of
microcrystalline cellulose, 5 to 45 percent of starch, 2 to 15 percent g of sodium carboxy
methyl starch, 0.1 to 10 percent of magnesium stearate, and 20 to 80 percent of water which is
taken as a humectant. The preparation method thereof comprises the steps as follows: (1)
components in prescriptions are gotten and filtered through a screen with 100 screen meshes;
(2) based on the proportion of the prescriptions, the lafutidine is respectively mixed with the
sodium carboxy methyl starch, the starch, the lactose, and the microcrystalline cellulose
uniformly according to the equivalent increasing principle; (3) the water is used as a wetting
agent, and granules (the grain diameter of which is 30 screen meshes) are manufactured through
a wet process and are dried for 2.5 hours through blowing at about 55 DEG C; (4) the
granules are filtered through the screen with 30 screen meshes, the magnesium stearate is mixed
according the prescription, and then the lafutidine tablet is obtained through tablet forming. The
formula of the lafutidine tablet is reasonable, and has the advantages of small dosage, good
tolerance, insignificant side effects, etc. compared with the similar drugs.