FR TE TAG HAIG se ee (GBB to 103 HS BZ + ERAS SA ZHPRE MA ARCS + RAL IIR IE Bek WAR » 4 SRANHEE B GREERENRERBHAEE ( SOLER STH A Bh A HWA | Itoh et al., 1995) ° RG + blto : Fucoidan» FX» Ht BHA KBE AP OT | LHRHRAMERMHAREH © eae AA EAR HRME BR + HB RPucoidanhe we HF A SEA fy Bk to STE + 3G Ao AAR % RU P EAS oe 4 ak cae Creel em Ene a: WE: HARERRABAKE (Keio University) ASRS #4) Division of Hematology, Department of Internal . Keio University School of Medicine, Tokyo, JapanHe THT FR EI MARR R BRRBARAHER (SARE | 2 AALS A RS PY AB i EH BR SP RARE » Ait t9 18 AS A —18 & B pro-caspase-3 HEH > sik 40 A Hyprocaspase-3 Fucoidanw caspase-3( fi] FF # ) RERKH 4 THRE FFARR) caspase-3 + PROBA ARE » 12S GIR AR procaspase-3ik #8 MATH Ricaspase-3 » Hw he > Gta > K RRR ° Healey T Ao oR Hohl > OREARE (EY SALE A AE Ri > PHAM A AH CIBUS Sultanda a7] CR AIL © Hide + RA mie SR American Journal of Hematology 78 (1): 7-14, PMID 15609279 doi :10.1002/ah.20182. Fucoidan + 24m Gi Bak oA) SR #8 > Pucoidantycaspase-3iy 16 tf A 4ERL > fo caspase ditt #]z2—VAD-FMK AFAR TL ARE AY HR EGS. Sultan MRR: ABP ewMc (apoptosis) © Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-8 and down-regulation of ERK pathways. 42 FlFucoidan 100 microg/ml 24/).RF te > AMA SAE RHS Sultan 9/8, BULBRRAT ° ERKSS42 + 27 eau EA a seamen #19964F + A HiFucoidan [ > EPOKAARSHPRER > Fucoidan® (AF ew) ACI A Cree Ces ZEBRK#eGSKSS4E HJ phosphorylation( BL) ARRAY T Fucoidan# A@Z HS Sultantah + 4 i8caspasefe SE ce ome ee ALS. 9038FIA4 HY 4 -Fucoidank RRA BARMRP + 22 Ree (Fucose) KEK GBR Sh AR © 1996 + HM Fucoidan TIA4 FY yg aA EA RBS EBOKARRERPRER (Had (HER ww Rew) At J EAL» APS HE © HIE HB ERMA H+ EI SM sPucoidan TIA SY HHH ABR » Waeigik TII4 FY 4 -Fucoidan#4ek 44 A OS Row RKmB)ATS fF Fl-(Apoptosis action) @RRAT BIEN OHA OSPR 1. HBR ow oH A BewMALKT Me ABRs 45h ¢ HFucoidan TFID4 HU H Hy Pea 8 J AE I + St a 3 KE AGREE PO RAR RBG OER RRB SH ee MOTAR BRABIR MBAS ER 2. Rin Eee fide TR OB AE RA By SEH toh» RIA He SET Re Ae HA to © 3. Ramey aE By A a to eR — 1 9 Eh te, LERATAY > PRR? H ERL AEB, TERA RI ETHRDY HREA LABOR BtoB T° A MONA HN VERE RMR wes EP RRA ¢ RA MPucoidany Hp Hel HK HB AE oe B+ AR WA EE FORD RAE UR IE Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro kK, Uchihara JN, Masuda M, Takasu N, Tanaka Y} Ohta T, Mori N.4a 2% : PUBMED: PMID: 16201850 [PubMed — indexed for MEDLINE] PRAT #0 HE G7 fo (ATL) + ASOT is aa Hs HH — FRAY HTLV—1) BF ek BSMTRR : AD AIP #8 Sy 5S 10 I > RAL AA MISH °K primary adult T-cell Fucoidans§ ##RHTLV 14938497 40, Mcapoptosiss B-HIMAR, Fucoidan Lak J NF-kappab4e i$ (t & & Y-1s ERT THANE kappaBs 11-451 48 82] Capoptosis > UHERAZLBLHY G miATeaye ° ME AAP BR REEREART Fucoidan > L469 $ RM > LFS ERALLAEM HRB © FucoidanfR 9 347 sb J ATL AP tn The BAK bon Ma Fo HAG RT Om FBHTLV 1 HBR R LERYEA ALES 8 sn HF HH tn © Fucoidan extracts induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and leukemia cells. chemokine » C-C chemokine ligand 5 ZA Ete Tse ET A 9 RS AL eR) Ade T ARHTLVY 14R RAH TAO AE homotypic haw ay geht A © | MUN RM > FucoidanHAILAs > S-MAWA HY > AM HIS | —