Scribd Logo
Upload

Welcome to Scribd!

  • Visualize and Manipulate Protein Structure Using Pymol: Chem 335 Physical Chemistry

    Uploaded by

    Philip Cheung
    12 views4 pages
    Chem 335 Physical Chemistry covers visualizing and manipulating protein structure using PyMol. The course discusses HIV protease and its interaction with ligands, specifically looking at how a Leu-508 mutation affects catalytic activity. According to a PyMol generated structure of HIV protease, residue 26T is far from the ligand, suggesting little catalytic activity.

    Original Description:

    Original Title

    Lab 9

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Chem 335 Physical Chemistry covers visualizing and manipulating protein structure using PyMol. The course discusses HIV protease and its interaction with ligands, specifically looking at how a Leu-508 mutation affects catalytic activity. According to a PyMol generated structure of HIV protease, residue 26T is far from the ligand, suggesting little catalytic activity.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    12 views4 pages

    Visualize and Manipulate Protein Structure Using Pymol: Chem 335 Physical Chemistry

    Uploaded by

    Philip Cheung
    Chem 335 Physical Chemistry covers visualizing and manipulating protein structure using PyMol. The course discusses HIV protease and its interaction with ligands, specifically looking at how a Leu-508 mutation affects catalytic activity. According to a PyMol generated structure of HIV protease, residue 26T is far from the ligand, suggesting little catalytic activity.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    Chem 335 Physical Chemistry

    Visualize and manipulate protein structure using pymol

    Chi Hang Cheung

    1) HIV protease:
    HIV protease interaction:
    Leu- 508 mutation:

    2) According to the HIV protease structure generated from pymol (fig. 1), the 26T residue is separated so
    far apart from the ligand and thus suggests that it has very little or no catalytic activity.
    (Figure 1)

    You might also like