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Rna Tech Antisense Tech
Rna Tech Antisense Tech
RNA technologies
V.1 Ribozymes
A specifically-designed ribozyme cleaves a specific pathogenic RNA molecule to make it inactive. For example, the viral RNA causing hepatitis C. Very promising results using cell cultures. The ribozyme is synthesized in vitro and administrated to the patient. Problems: half-life too short and low potency once in the body.
The antisense RNA procedure for blocking or reducing the level of expression of a specific gene.
What is the antisense oligonucleotides? The term antisense oligonucleotides refers to molecules made of synthetic genetic material, which interact with natural genetic material (DNA or RNA) harboring the information for production of proteins.
Antisense Oligonucleotides are unmodified or chemically modified ssDNA, RNA or their analogs. They are 13-25 nucleotides long and are specifically designed to hybridize to the corresponding RNA by Watson-Crick binding
AntiAnti-mRNA Strategies
2. Activation of RNase H