Non-Alcoholic Fatty Liver Disease

Definition and Epidemiology Salandanan, Rea Y.

Definition
Spectrum-ranging from steatosis to NASH to cirrhosis Fatty change- accumulation of lipids within hepatocytes. associated with central obesity, type-2 diabetes mellitus, insulin resistance and dyslipidemia

Harrison's Principle of Internal Medicine 17th ed http://emedicine.medscape.com/article/175472-overview http://www.medscape.com/viewarticle/578709_2

Epidemiology
US and Europe
NAFLD Prevalence of 14-20 % Obesity, diabetes mellitus

US
NASH ~3% fibrosis secondary to NASH in >40% of significantly obese patients

Harrison's Principle of Internal Medicine 17th ed

Epidemiology
Asia Pacific
Prevalence figures of 10% to 29% obtained from large surveys in China, Japan, and Korea Japan- ~13% 1988 to ~30% in 2004 Male predominance in younger population
Peak in men occurs (40-49 years), women (over 50 years)

NAFLD in the Asia-Pacific Region: Definitions and Overview Guidelines: NAFLD is an Emerging Problem in the Asia-Pacific Region, and is Likely to Increase in the Future retrieved from:http://www.medscape.com/viewarticle/559336_3

Epidemiology
Philippines UP PGH -NAFLD was diagnosed in 134 from a total of 1102 patients (12.2%) Mean patient age was 42.2 years

NAFLD patients
female male diabetes hepatomegaly obese

% (+) NAFLD

29% 0% 71% 20% 40% 60% 80%

Non-alcoholic fatty liver disease in the Philippines: Comparable with other nations?Mark Anthony A De Lusong, E Labio, L Daez, V Gloria World J Gastroenterol 2008 February 14;14(6): 913-917 Retrieved from:http://www.wjgnet.com/1007-9327/14/913.pdf www.wjgnet.com World Journal of Gastroenterology