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Pathophysiology

Predisposing Factors: Race Age Sex Genetics

Precipitating Factors: Inadequate release of TSH Iodine deficiency and excess Autoimmune reponse Atrophy of thyroid gland with aging Radiation of Head and Neck Cancer Drugs (Lithium, Antithyroid)

Loss of thyroid tissue

Caused by the pituitarys failure to synthesize adequate amounts of TSH Pituitary Tumors

Decrease Thyroid Hormone Primary Hypothyroidism Secondary Hypothyroidism Hypothyroidism

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