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Dark urine Fatigue Pale color (pallor) Rapid heartbeat Shortness of breath Yellow skin color (jaundice) Exams and Tests An examination may reveal an enlarged spleen. Tests include: Direct Coombs' test Hemoglobin in the urine Indirect Coombs' test Red blood cell count and serum hemoglobin Reticulocyte count Serum bilirubin levels Serum haptoglobin
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