Alfentanil

Intermediate
extraction

T1/2 , Vd
,
CL , fp

(dose-dependent)
Cefoperazo
ne

low extraction,
high protein
binding

Ceftriaxone low extraction,

high protein
binding

Chloramphe low extraction,

nicol

high protein
binding

Chlordiazep low extraction,

oxide

high protein
binding

Clindamyci low extraction,

n

high protein

Clofibrate

low extraction,

binding

high protein
binding

T1/2 , Vd

one

extraction

,
CL 60%, fp ?
T1/2 , Vd

, CL
, fp

T1/2 , Vd

,
CL 65%, fp

acute viral

hepatitis

:T1/2 , Vd ,
CL 60%, fp
T1/2 , Vd
,
CL 23%, fp

T1/2 , Vd
,
CL CLint

50

50%
, fp

Dexamethas Intermediate

T1/2 , Vd
,


Prazosin

high extraction

T1/2 ,

CL , fp
Propoxyphe high extraction
ne

Intermediate

T1/2 , Vd ,

low extraction,

T1/2 , Vd ?,CL

T1/2 , Vd ?, CL

Quinidine
Rifampicin

extraction

high protein
binding

Tocainide

CL 25%, fp

50

high extraction

xazole

Vd ?,

T1/2 , Vd ,

Propanolol

Sulfametho

T1/2 ,

low extraction,

CL 60%, fp
CL , fp
, fp ?

high protein
binding

high extraction

Triamterene high extraction

T1/2 , CL

,
fp
Valproic
acid

Verapamil

low extraction,
high protein

T1/2 , Vd

binding

CL 40%, fp

high extraction

T1/2 , Vd ,

CL 60%, fp

50